New paper out today @JTHjournal : "Genetic risk and incident venous thromboembolism in middle-aged and older adults following #COVID19 vaccination" . A short 🧵
1/n) Some #COVIDvaccines have been associated with increased risk of blood clots (VTE). We wanted to understand if genetic predisposition to VTE would predict risk of post-vaccine VTE, and if vaccination interacted with underlying genetics
2/n) We used data from @uk_biobank to investigate this, linking genetics, vaccination and health outcomes information. We generated a polygenic risk score using known variants, and studied associations between PRS and incident VTE immediately after vaccination, and historically
3/n) We included 359,310 vaccinated individuals, and saw 88 and 299 VTE within 28 and 90 days respectively. Genetic risk summary PRS was significantly associated with more VTEs in both cases, as well as in historical (prevaccine) data
4/4) Our findings suggest that, at the population level, VTEs after COVID-19 vaccination have a similar genetic aetiology to conventional (vaccine-unrelated) VTEs
This work was funded by @EMA_News but does not reflect the opinions of the agency or any of its committees. We led this work independently from @UniofOxford and @erasmusuni . Thanks to @XieJunqing @Prats_Uribe_A for their leadership!
• • •
Missing some Tweet in this thread? You can try to
force a refresh
