Myoclonus-Dystonia syndrome (MDS) is a very interesting diagnosis to be aware of as it can become quite disabling for patients from a movement disorder and a psychiatric standpoint! 🧵#movementdisorders #MedTwitter #NeuroTwitter #MedStudentTwitter #MedEd
-Onset is typically in childhood with myoclonus alone or in combination with dystonia.
-Most cases are due to inherited SGCE gene mutations
-Symptoms are very alcohol-responsive *which can lead to abuse and addiction*
-Co-morbid anxiety, depression, OCD, etc. are common
-Most cases are due to inherited SGCE gene mutations
-Symptoms are very alcohol-responsive *which can lead to abuse and addiction*
-Co-morbid anxiety, depression, OCD, etc. are common
- The myoclonus preferentially affects the upper body but spreads to the lower body with action
- Zonisamide has Class I evidence for the treatment of myoclonus in MDS
- Zonisamide has Class I evidence for the treatment of myoclonus in MDS
- The dystonia if present preferentially affects the cervical region, lower extremities and gait, or manifests as writer’s cramp
*So always watch your patients write!* ✍️
*And ask about a family or personal h/o gait impairment, “dragging the leg,” wearing ankle braces, etc.*
*So always watch your patients write!* ✍️
*And ask about a family or personal h/o gait impairment, “dragging the leg,” wearing ankle braces, etc.*
If medications like zonisamide, VPA, Keppra, Benzos, anticholinergics, and botulinum toxin are not enough to control the myoclonus and dystonia, GPi DBS can help!
Learn more about the treatment of MDS in this review: prd-journal.com/article/S1353-…
Learn more about the treatment of MDS in this review: prd-journal.com/article/S1353-…
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