Myoclonus-Dystonia syndrome (MDS) is a very interesting diagnosis to be aware of as it can become quite disabling for patients from a movement disorder and a psychiatric standpoint! 🧵#movementdisorders #MedTwitter #NeuroTwitter #MedStudentTwitter #MedEd -Onset is typically in childhood with myoclonus alone or in combination with dystonia.

-Most cases are due to inherited SGCE gene mutations

-Symptoms are very alcohol-responsive *which can lead to abuse and addiction*

-Co-morbid anxiety, depression, OCD, etc. are common

Hey #Medtwitter & #Neurotwitter With 2 simple rules you can learn the #basalganglia direct and indirect pathways for the LAST TIME and actually remember them! 🤯Here’s how! 🧵 :
#MedEd #medicalstudent #Neurology #Neurologyresident #Movementdisorders #Neuroscience #Neuroanatomy Rule 1: The “OG” basal ganglia (striatum and globus pallidi) use GABA ➖as their neurotransmitter. Everything else uses glutamate ➕.

Rule 2: Once you know Rule 1, all you have to do is memorize the order of the structures:

Direct pathway: CS___GiT
Indirect pathway: CS GeS GiT