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Paul Maidowski Profile picture
@_ppmv
Oct 17, 2022 • 40 tweets • 28 min read • Read on X
My ancestor Arthur Schlossmann founded the world’s first pediatric clinic in Dresden in 1898, bringing infant mortality from >50% to 22%. This @UniklinikDUS is dedicated “To the savior of the children.” Don’t expose kids to SARS-CoV-2 in school/hospitals. It’s NOT inevitable. 1/k Image
Some think we need to learn to “live with” COVID-19, a virus that causes paediatric lymphocytopenia. This is the equivalent of thinking in 1898 that we need to learn to “live with” 50% child mortality. - No difficult call. Any toddler understands this. 2/k saebi.isgv.de/biografie/Arth… ImageImage
German national and medical history is rich in historical parallels. - Another ancestor is pediatrician Albert Eckstein. 3/k rp-online.de/nrw/staedte/du… ImageImage
Many have better insights into the treatment of SARS CoV 2 by professional associations or western medicine, but anyone who reads widely will see we face profound problems. As one anecdote, this thread by @KinderdocNina. (Neurologists, not pediatricians, but you get the idea) 4/k
Why is there so little resistance to the “we have to live with Covid” idea. Exceptions on #medtwitter & other venues stand out. But the trend is dark. If you don’t know what I mean, read anything by @fitterhappierAJ & other scientists who warn clearly. 5/k easychair.substack.com/p/dont-worry-a… Image
I’m not qualified to tell which clinical picture is emerging, but even the small part of the literature I surveyed is alarming. - Many will claim that we need to learn to “live with” SARS CoV 2 no matter what. We know this because they have shown us over the past three years. 6/k
To be blunt, unless you see our warnings comprehensively disproven, follow the precautionary principle and assume that scientists, activists, organizers like @dbdugger are more right than wrong. We are heading for significant problems that few people dare even discuss so far. 7/k
We are not even doing the perhaps counterintuitive analysis yet that could serve as basis for planning & solutions. Bring difficult questions to the attention of the HCWs, scientists & policymakers in your lives. Too much is at stake not to focus now. 8/k uniklinikum-dresden.de/de/das-kliniku… Image
If SARS cov 2 questions are too subtle or complex to change policy in time, take Ebola, in many ways as good or a better parallel than HIV. Good luck minimizing this one. We keep coming back to Jay Forrester‘s correct observations on system dynamics and medicine. 9/k
System dynamics is „at about the same state of advancement that engineering was when MIT first opened its doors in 1865, or that medicine was in the late 1800s when the Johns Hopkins School of Medicine was established.“ moodle.nccu.edu.tw/pluginfile.php…
„We have as much to learn yet about high-order nonlinear feedback structures around us as those earlier professions have already learned about their fields in the last 150 years.“ —Forrester 2007

We should waste no more years on foreseeable & foreseen unforced errors. Good luck!
Don’t think we exaggerate. Learn from history and learn fast. 13/k Image
In case the above was too subtle. 12/k
I admit it’s incredibly complex in part. Yet societies overcame terrible odds before. Many of us can do so too now. 14/k
Between 1 in 13 and 1 in 30 adults already live with long covid (=chronic SARS CoV 2 infection) in the U.S. and UK. - This is what the most important graph looks like for HIV. No one can guarantee that SARS CoV 2 doesn’t behave in similar patterns. Image
Not even climate experts discuss what is obviously a climate-relevant event in human history and arguably a social tipping point. Only China, perhaps counterintuitively, is not in denial. Ask serious analysts and policymakers working on these question: What’s the plan? 16/k
If you struggle to explain what you see around you, even change in people you knew well, I recommend @1goodtern's clear-eyed views on human souls. I previously mentioned this for climate; (don't mind layout - old draft & links won't work). Reread Arendt. Image
@1goodtern I don't think we are quite as far gone as the first warnings, here by @sammy4723, could imply. Will we get there if we let SARS CoV 2 evolve unmitigated in the population? Without a shred of doubt. Should you learn and take precautions? I do. Be well. 18/k
@1goodtern @sammy4723 Most weird SC2 sequelae "can be traced back to excessive Complement activation. Nearly every one of them. I've come to think of Complement as a timekeeper; catching Covid makes the hands of the timekeeper's clock move much faster." May this image help. f/k
@1goodtern @sammy4723 wow. @GVDBossche was right about immune escape. But it does NOT follow that we should expose children or vaccinated or unvaccinated adults repeatedly or even once to an HIV-like virus that causes chronic disease in 1/6 and brain damage (SAND) in ~2/3. 20/k
@1goodtern @sammy4723 @GVDBossche What you do "to protect yourself has now become an act of defiance against this wretched system. If you've experienced the push back simply by trying to avoid infection you have stood up for what is right; the right to not be infected. The right to live." - Will be proven right.
@1goodtern @sammy4723 @GVDBossche This quote shows what many who are aware of the near-mythical powers of SARS CoV 2 now anticipate. I think it is correct in as far as the virus is concerned; for 'the (political) system' not because it is made up of people who are mostly well-intentioned but in over their heads.
@1goodtern @sammy4723 @GVDBossche A tale of two events in Berlin yesterday. This on climate migration and #LossAndDamage was great, with strong female panelists and a focus on feminist FP. I added some Covid remarks (had to leave early) but complexity is too high for them to register. 23/k
@1goodtern @sammy4723 @GVDBossche More important, the Auswärtige Ausschuss shows what I long warned would happen. #ZeroCovid/#清零政策 strategy and any German/EU response were not even mentioned - in a hearing on systemic rivalry with China. @MiRo_SPD @TErndl? bundestag.de/ausschuesse/a0… 24/k ImageImage
@MiRo_SPD @TErndl @oertel_janka quoted XJP but her talk at #TDI22 showed she doesn't understand zero Covid policy. By the next election, Sept 2025, everyone will know the nature of SARS CoV 2. Sadly it will be too late. If you invite uncritical experts this is what you get.
@MiRo_SPD @TErndl @oertel_janka Debate in regular (=secret) AA hearings is too little too late. Vast investment is needed NOW to eliminate Covid. I've been warning for 1000 days, but was too cautious at times. Here: assume SARS CoV 2, an HIV-like virus, establishes viral reservoirs. 26/k
If you want real expertise, then I would totally take up offers like this one. Very minimal anger at the millions of lives needlessly lost already - and MANY more on the way - so this is a good deal. I would not wait, because it can only escalate the longer we twiddle our thumbs.
What to do. (1) Take up this offer by @RealCheckMarker + likeminded scientists. We face a world of undiagnosed SARS brain damage in most people (SAND). It can be a highly nonlinear process. You don’t have decades left; even for the HIV equivalent (HAND) we have no therapies. 28/k
(2) The goal is to stop any viral reservoirs and prevent progression to severe disease. A Twitter friend recently said he recognizes me a healer, which is kind but really only applies to good souls like @dbdugger. Here he makes an observation many medical professionals may share:
(2a) It’s good to hear clear language. I respect Dr Fauci’s skill in navigating the jungle of US Congress & conflicting interagency interests & wonder why so few asked why he is being pushed out at the end of 2022. But we need more who are willing to warn clearly. @SmithInAmerica
Read this carefully. We are heading for a world in which childbirth will be a significant risk again in countries that didn’t prevent infection. Few people will be privileged enough to live long past retirement age. If that’s the world you want, keep going. If not, change course.
As activists tend to get suspended, be sure to save or screenshoot information useful to you (today @DonEford). I don't expect us to be suspended fast, but thought the same for Don. We may now face real problems. You've been warned. researchgate.net/publication/36… Image
@DonEford This is what we know. Tell me of any errors - happy to update as public health advice comes online. There's a wealth of knowledge that can be made accessible, if we care. Schools are key to transmission, so parents and children need to understand. 33/k Image
@DonEford You now know why I've long claimed not 'climate policy' but SARS-CoV-2 initiated climate mitigation. For 5-10 years we've been warning that decarbonization would occur one way or another, by design or by disaster. Choose the "design" way. Much more humane.
@DonEford What worries me most is the neurocognitive impact of SARS CoV 2. How do we know? Here a study on SARS survivors 15 years after infection. There were no reinfections - arguably a best case scenario. Consider what this means for infants and adolescents! 35/k
@DonEford We need to focus. It's a formidable governance challenge because those who govern us are likely THEMSELVES affected - recall, most with SARS cov 2 Associated Neurocognitive Disorder (SAND) will be asymptomatic and won't even suspect it themselves.

Link: nature.com/articles/s4141…
@DonEford (1) The MoCA test is free for students/academics/profs, affordable for others. Dan assures me his SAND version doesn't look like this 😂. If it may help, follow his trials. (2) Start here & read deep. (3) All this is raw & cutting edge, I'm sorry. Be well,
@DonEford I need to change format because our collective (at least my) current MO is out of proportion with the severity of the challenge. Still, you can support my work on Patreon (DM for paypal). - Let's get to the heart of this. Thanks all, be safe+well everyone! patreon.com/paulmaidowski
@DonEford Also, @DonEford and many others activist-researchers remain suspended. Don alerted me to the fusogenic superpowers of SARS-CoV-2. (Note the HIV parallel!) We tied ourselves in a tight knot.

@elonmusk, check this. What will you do? - One essential shortcut Image
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More from @_ppmv

Paul Maidowski Profile picture
Nov 19
1. May do SARS-CoV-2 science threads when I find time. "While association between ABO blood group and infection is well known for many years, lower susceptibility of O blood group to coronaviruses had already been reported nearly 20 years ago for SARS-CoV" degruyter.com/document/doi/1…
2. Transplacental SARS-CoV-2 protein Orf8 binds to complement C1q to trigger fetal inflammation - Yes, as we've been saying for years. Orf8 makes SARS (CoV-1/-2) unique among coronaviruses. Let's infect all the kids so we are really, really sure that's bad embopress.org/doi/full/10.10…Image
3. SARS-CoV-2 can trigger a devastating, destructive placental pathology causing placental dysfunction and fetal hypoxia, yet stillbirth is rare. The fetal hypoxia is acute/subacute, apparent as reduced fetal movements. 20% of participants in this study(!) sciencedirect.com/science/articl…Image
Read 8 tweets
Paul Maidowski Profile picture
Sep 20
1. The structural parallels of SARS-CoV-2 and HIV-1 were known already 20 years ago, from SARS-CoV-1. Yet COVID-19 policy and even most scientists ignore these parallels, failing to learn key lessons. Fundamentally, genetic recombination drives both pandemics—two typical articles

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2. Don't worry about the specific article—there are hundreds more, and more relevant ones. The lesson here is we face syndemics, overlapping epidemics that cluster with inequity, not just distinct pandemics. All reinforce each other
link.springer.com/article/10.118…
frontiersin.org/journals/micro…
3. Background. There are literally thousands such articles; no one integrates them. That's why as political scientist, for years already, I've been arguing that only institutionalization can help with such complexity. We need a @UNAIDS for SARS-CoV, sorry
Read 29 tweets
Paul Maidowski Profile picture
Aug 30
1. Growing bamboo is our best chance to avert climate breakdown: the plants build soil, help biodiversity, avoid GHG emissions, provide food & construction material, sequester carbon 30 times (!) faster than mixed temperate forest. Yet stunningly, no one coordinates this work yet 40 year old moso bamboo in southwestern France grown from seed. Photo Lihua Jiang, www.yunnan-bamboo.com
2. After 40 years of climate science - first AGGG, now IPCC -, everyone feels they know climate. Yet experts only really know their own field. Generalists and practitioners can implement solutions but need experts to develop them. Bamboo as climate solution is entirely unexplored
Two bamboo stands in Zhongshan Expo Park, Taipei
Bamboo species in Tapei botanical garden
3. Last time atmospheric carbon content was as high as today, 16 million years ago, Earth was >3°C warmer than today, the Arctic was ice free, and Iceland had a subtropical climate. People think they know what climate change means, but most really don't. mdpi.com/2673-4834/5/2/…
Read 47 tweets
Paul Maidowski Profile picture
Aug 21
We’ve shared this for years, it was known or suspected even before the pandemic from SARS-CoV-1. Friends of we’re going to learn at this rate, ignoring prepandemic science, populations worldwide will get into serious trouble
Background. Thanks for outstanding science communications @vipintukur
I'd like to delete my account, but then a sizable fraction of the early Covid twitter scicomm documentation - to show what was known when - would be gone. As far as I know, no one else with even a moderately sized account (>10k followers) shares the same readily available science
Read 5 tweets
Paul Maidowski Profile picture
Jun 13
“Bamboo is our best chance to slow climate breakdown. It can replace drivers of GHG emissions and biodiversity loss (food, construction, concrete, plastic), build soil & allow regrowing rainforest." - Let's test it. Grow bamboo as blueprint for a future ecological civilization 🧵
Moso bamboo (phyllostachys edulis) seedling grown from seed with tap root
Moso bamboo forest in China, stock photo
2. Giant bamboo dwarfs trees. As grass, it grows 30 times (!) faster and can be harvested every year. Timber takes decades; too slow. Stunningly, no one in the west described the unique climate mitigation potential of bamboo yet. - Note the rhizome system:

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3. Climate relevant will be the use in millions of ha of plantations, just like other economically important crops. After two months on this, some significant progress: air pot kindly donated 1 m of their professional U system, so I can test it for bamboo.
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Read 39 tweets
Paul Maidowski Profile picture
Jun 4
SARS-CoV-2 reminder: The more immune compromised the population, the less symptoms, the ‘milder’ it appears, the more severe it really is (=Long Covid, long term damage). That’s what even most scientists seem not to get
Thanks for vivid discussion everyone. It really is a fundamentally important point. Since I deleted most references for lack of structure (and frankly, just being fed up repeating the same points for 3 to 4 years), I'll look for new references that must have been published by now
Background
Read 8 tweets

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