Jamie Metzl Profile picture
Oct 23 25 tweets 8 min read
I just finished @DavidQuammen new book, Breathless. David does a great job making the case for a zoonotic origin of #COVID19 but a poor job presenting the alternate hypothesis of a potential lab accident origin. My further thoughts in the thread below. 1/ simonandschuster.com/books/Breathle…
David has been transparent in stating he does not feel the lab origin hypothesis deserves full attention. In his TWIV podcast, he suggests it merits about 10% attention, vs 90% for zoonosis. 2/ microbe.tv/twiv/twiv-948/
It's fair for David to have this bias, even if I do not believe it supported by the available evidence. Although @mattwridley & @Ayjchan presented both sides in their (excellent) book Viral, some accused them of leaning toward the lab hypothesis. 3/ theguardian.com/books/2021/nov…
But I think Matt and Alina more fairly present the case for zoonosis than Quammen presents the case for a possible #COVID19 lab origin. For example… 4/
Quammen does not even mention the March 2018 DARPA proposal. As I told @VanityFair: “If I applied for funding to paint Central Park purple and was denied, but then a year later we woke up to find Central Park painted purple, I’d be a prime suspect.” 5/ vanityfair.com/news/2021/10/n…
(Here’s a link to the #DRASTIC site on the DARPA proposal.) 6/ drasticresearch.org/tag/darpa/
Quammen references the 2022 GAO et al paper on pandemic origins as supporting the market origin hypothesis, but conveniently fails to mention that the Chinese scientists call the market an “amplifier” location, not the source, of the outbreak. 7/ assets.researchsquare.com/files/rs-13703…
Quammen stresses, correctly, that the RATG13 virus could likely not be a backbone for #SARSCOV2, but leaves the inaccurate impression that most people who believe a lab origin is possible believe that to be the case. It is not. 8/
Quammen underplays the significance of the statements by @WHO chief @DrTedros calling for a full investigation into all origin hypotheses, full access to the raw data in China, and for an audit of the Wuhan labs. Dr. Tedros has been, in my view, a hero on the origins issue. 9/
Quammen barely explore how deeply flawed the WHO-China joint study process was, with Chinese government minders overseeing everything, including the votes by team members of which hypotheses were more or less likely. 10/
Quammen doesn't mention that WHO disbanded the joint study after recognizing how deeply flawed it was. He does not reference that the WHO created SAGO to address those flaws, or that SAGO has supported a full investigation into all relevant hypotheses. who.int/groups/scienti… 11/
More broadly, Quammen seems to give the Chinese government a pass, paying little attention to its aggressive efforts to destroy samples, hide records, and squash any investigation into pandemic origins. 12/
He treats Shi Zhengli as if she were a scientist working in Switzerland, not China. No matter how honorable she may be as a person, it would be absurd to believe she has the total freedom to speak and act as she pleases. 13/
Quammen also does not even reference US gov’t claims that the Chinese military was involved with activities at the WIV. Here’s some background on my interaction with Shi Zhengli. Either she or the USG is lying. At very least, this is worth exploring. 14/ dailycaller.com/2021/03/23/shi…
He blindly (& absurdly) references Holmes & Daszak saying those of us calling for a full investigation into pandemic origins caused China's gov't to clam up. The Chinese coverup started right away, before we started raising essential questions. 15/ wsj.com/articles/how-t…
Quammen adds some significant reporting that is interesting and additive. He says that Matt Wong’s pangolin genetic analysis was the key input changing Kristian Andersen et al’s mind in February 2020 (even though Wong's data does not explain the FCS). 16/
Remarkably, he also reports that the Chinese government requested that Peter Daszak serve on the @Peterfoodsafety joint study team. It’s a huge deal that the Chinese candidate was selected while the investigative experts proposed by the US gov’t were hardly even considered. 17/
I have great respect for David Quammen. I love his books and believe he is a person of highest integrity. He is honest about his personal beliefs and his relationships. Anyone who writes a book, particularly a good book like this, deserves our praise. 18/
Good books like this inspire us to think differently and to engage in (hopefully) respectful debate with others. 19/
I have great respect for the many virologists and others who have been working hard on the origins issue, including Andersen, Rambaut, Holmes, and others. All of these people could probably have far cushier lives doing something else. 20/
I also have great respect for top scientists who remain more open to all origin hypotheses, including Bloom, Courtier, Decroly, Ebright, Lipkin, Relman, Wain-Hobson and many others. /21
Many leading scientists have told me privately they believe a lab origin is likely but choose not to speak up because the data is not determinative and the climate is too toxic. I wish they would speak up. 22/
I encourage all scientist and others engaged in this debate to do so with respect and decorum. Personal attacks and silly name-calling are beneath us all. 23/
The #COVID19 origins question is by no means settled. For the sake of future generations, we must keep pushing until we can determine how this terrible and largely avoidable crisis began and until we can best address our greatest vulnerabilities. 24/
More background and useful links here. 25/ jamiemetzl.com/origins-of-sar…

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More from @JamieMetzl

Oct 23
I was so incredibly impressed by the work of these Chinese agronomists I sent them a note expressing how grateful I was for the contribution to humanity. pubmed.ncbi.nlm.nih.gov/35862527/
In my email, I said: "Although relations between our countries (I am an American) are deteriorating rapidly, the possibility of working collaboratively to solve some of our world's greatest challenges must still give us hope and offer a better path forward."
I received a very nice note back saying: "Thank you very much for your recognition of our work and interest in our work! We just have done what we should do."
Read 4 tweets
Jul 26
Congrats to authors of the research article published today in @ScienceMagazine proving what we already knew: the Huanan seafood market was a #COVID19 superspreader location. Unfortunately, media & Twitter comments by some of the authors borders fraud. 1/ science.org/doi/10.1126/sc…
On Feb 26, 2022, the Worobey et al preprints were released with associated language asserting they provided “dispositive evidence” of a market origin. 2/ zenodo.org/record/6299116…
The following day, @carlzimmer wrote a Sunday @nytimes cover story based on these non-peer reviewed preprints highly favoring the market origin hypothesis. Just look at the title. 3/ nytimes.com/interactive/20…
Read 17 tweets
May 19
Critically important new PNAS opinion piece by @JeffDSachs & Neil Harrison calls “on US government scientific agencies, most notably the @NIH, to support a full, independent, and transparent investigation of the origins of #SARSCoV2.” 1/13 pnas.org/doi/10.1073/pn…
Although no new evidence presented, Sachs and Harrison state what should now be obvious to all: 1) we still don’t know #COVID19 origin, 2) we must if we are to build a safer future, 3) China blocking & 4) we must do our best to investigate regardless. 2/13
While it’s true that “much could be learned by investigating US-supported & US-based work that was underway in collaboration with Wuhan-based institutions,” we can’t lose sight of China’s criminal coverup. I've been saying this for a very long time. 3/13 wsj.com/articles/how-t…
Read 13 tweets
Apr 11
We all remain at unnecessary risk until we determine how the #COVID19 pandemic began and address our greatest vulnerabilities. Any serious investigation of this issue must address the following 23 questions.
1: Why did the Chinese government either not carry out a full contact tracing to find the #COVID19 index case or do so and not share the results?
2: Why did the Chinese government in January 2020 knowingly lie to the @WHO about human transmission of the #SARSCoV2 virus then prevent WHO experts from travelling to Wuhan for nearly three weeks?
Read 25 tweets
Mar 2
The @nytimes reported, inaccurately in my view, that two recent preprints establish the Huanan market as the location of the first #SARSCoV2 human infection. I invite @MichaelWorobey & the other authors to answer the following questions re their claims. nytimes.com/interactive/20…
Question 1: What is the relationship between people working in and living near the Huanan market and how do you distinguish between them in your analysis? Presumably, some people work in the market but live far away.
Question 2: How do you account for the discrepancy between the phylogenetic data suggesting an initial outbreak in late October or early November 2019 and the #COVID19 infections from December you discuss in your papers?
Read 13 tweets
Dec 3, 2021
The late Phillip Russell, former president of the American Society of Tropical Medicine and Hygiene, was a big deal. That's why I encourage everyone to read carefully the email he sent in April 2020. 1/11 usrtk.org/biohazards/bio…
"The flimsiness of the epidemiology pointing to the wet market, the absence of bats in the market, the failure to identify an intermediate animal host, the extraordinary measures taken by the Chinese gov't, including persecution & probable killing of two brave physicians... 2/11
... to cover up the outbreak, the steps taken to silence the laboratory personnel,. the change in leadership of the lab, all point to the lab as the source of the outbreak.” 3/11
Read 11 tweets

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