1. Short #Ebola thread.
The outbreak in Uganda is getting quite large. Very concerning situation. But there's been some extraordinary good news. Merck, which makes the first licensed Ebola Zaire vaccine, has found it has 100,000 bulk doses of Ebola Sudan vaccine.
2. @sciencecohen reported on this amazing situation. Merck relinquished the IP for the #Ebola Sudan vaccine several years ago, but while it still held it the company made bulk vaccine as a hedge against an Ebola Sudan outbreak. It's still viable. science.org/content/articl…
3. @WHO is already planning a clinical trial of candidate vaccines which is supposed to start soon. The Merck vaccine, which stands a good chance of being effective, will surely be added to the mix. I wrote about the clinical trial late last month. #Ebola statnews.com/2022/09/29/ebo…
4. Getting a good handle on how large this #Ebola outbreak is has been ridiculously hard. Uganda is not being transparent about numbers. They are not including probable cases in their counts, even though they should be. health.go.ug/ebola/
5. Uganda says there've been 75 confirmed #Ebola cases & 28 deaths. But there are 20 probable cases that need to be added to those tallies.
And that 75 number is out of date. Suffice to say there have been over 100 cases to date and 48 deaths.
6. Most alarmingly, there have been quite a few cases in Kampala, the capital. #Ebola in cities is really bad news. A chain of transmission spanning more than a dozen cases started there when an infected man fled to Kampala.
7. If you want to know more about the work that led to Merck's #Ebola Zaire vaccine — and the Ebola Sudan vaccine that will be tested in Uganda — I wrote about in early 2020. statnews.com/2020/01/07/ins…

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More from @HelenBranswell

Oct 21
1. A short #flu 🧵
I started this week with a story about the fact that @CDCgov is seeing signs of an early start to the flu season. Some of those signs are apparent in this week's Fluview, which reports on flu activity for the week ending Oct. 15. statnews.com/2022/10/17/cdc…
2. The percentage of #flu tests that were positive for flu were 2.5% three weeks ago, 3.3% two weeks ago & 4.4% last week. Flu hospitalizations are climbing. Transmission is heating up in the SE & southcentral part of the country, but starting up the Eastern seaboard too.
3. The percentage of people going to doctors for respiratory illness is rising. (See the 2022-23 curve in the blue circle.) Pre-Covid, activity above the dotted line was typically thought to be mainly #flu. This graph will be harder to read in an era where flu & Covid coexist.
Read 5 tweets
Oct 19
1. Short thread from @WHO's weekly press conference. Covid-19 remains a Public Health Emergency of International Concern (PHEIC), the @WHO emergency committee decided at a meeting last week. Today @drtedros said he agrees.
2. The EC chair, Didier Houssin, said for the first time at this meeting, the committee talked about the possibility of terminating the PHEIC. But the committee concluded it was too early to do so. Among other things, they want to see how this winter goes in the NHemisphere.
3. @DrTedros revealed that @WHO and partners have decided to effectively ration #Cholera vaccines, because of a global shortage. Normally cholera vax is given in 2 doses but will be used as a 1 dose vaccine. This strategy has been shown to be effective before.
Read 10 tweets
Oct 19
1. #ACIP is meeting today & tomorrow. This is one of their 3 scheduled meetings that take place every year.
There will be some discussion of Covid vaccines today, but this meeting will not be primarily about Covid vaccines. Lots of items on this agenda. cdc.gov/vaccines/acip/…
2. I will NOT be live tweeting much in this meeting. When I do tweet, I will do it in this thread.
There are not going to be many votes during these 2 days. Many of the sessions will be about informing #ACIP members on vaccines in development (eg. chikungunya).
3. There'll be a vote about adding Covid vaxes to the Vaccines for Children program. With federal money for Covid all but exhausted, the full cost of future boosters will be paid by individuals or their insurance. This is about ensuring kids without insurance can get vaxed. #ACIP
Read 27 tweets
Oct 17
1. Two fascinating reports from 2 different @CDCgov journals today on #monkeypox acquisition via needlestick injuries. The takeaway message for me: If you are a HCP & you have a sharps injury involving MPX, you probably want to get vaccinated right away.
2. The first report came out in #MMWR. A Florida nurse who was using a syringe to extract fluid from a suspected #monkeypox lesion pricked her finger, drawing blood. She got the first of 2 doses of Jynneos within 15 hours & only developed 1 lesion. cdc.gov/mmwr/volumes/7…
3. The 2nd report, in @EIDjournal, is about a Portuguese doctor who had a similar needlestick injury while sampling a suspected #monkeypox lesion. There was no bleeding, he thought his glove was intact, and he didn't report the exposure. He was not vaccinated.
Read 5 tweets
Oct 14
1. A short #flu update:
@CDCgov has posted the FluView report for the week ending Oct. 8. It is the first FluView report for the 2022-23 flu season.
Flu activity is ticking up a bit, especially in the southeast and southcentral parts of the US.
2. The increase in #influenza-like illness (not all #flu) seems to be most marked in young kids, which isn't much of a surprise. Little kids always catch a lot of respiratory infections; kids who were protected from them in the early part of the pandemic may catch more for awhile
3. Something I do find surprising is that #flu outbreaks in long-term care facilities are still really rare. 0.3% of LTCF reported a flu outbreak last week. Seniors are really susceptible to flu & LTC outbreaks were common in the before-times. Will be again, no doubt.
Read 4 tweets
Oct 5
1. Turning this into a short #Ebola thread:
Uganda's health ministry is producing daily or near daily situation reports (I've seen some), but they are not being released to the media, as far as I can tell. It's been challenging finding up to date data on what's going on there.
2. There have been at least 10 #Ebola infections in health workers. To date 4 have died. The following info comes from the twitter account of Uganda's health minister. The deceased are: Ms. Nabisubi Margaret, an anesthetic officer; Dr Mohammed Ali; an unnamed midwife and ...
3. ...and an unnamed health assistant in Kagadi District. Tragic losses.
Cases have been reported in at least 5 districts in the country.
I am not sure at this point how many confirmed & probable cases there have been. Between 61 or 63, I think. I think there've been ~30 deaths
Read 5 tweets

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