This one in individuals at clinical high-risk for psychosis suggests that the beneficial impact of omega-3 PUFAs on clinical symptoms in psychosis is mediated, at least in part, through the complement and coagulation pathway proteins. 
- The complement system is a network of proteins that play an important role in host defense and inflammation.
- The coagulation system, you guessed it, is the good ol' system that is made up of blood cells and proteins, responsible for creating blood clots to allow for rapid healing and prevention of excessive bleeding.
- The group had previously shown in this sample that supplementation with fish oil can have beneficial effects.
Ref:
doi.org/10.1016/j.biop…
Ref:
doi.org/10.1016/j.biop…
- Using mass spectrometry, the group now provides evidence for a plausible mechanism of action of omega-3 PUFAs in early psychosis patients.
- The change in total omega-3 PUFAs was associated with plasma proteins that represent inflammation, clotting and vesicle mediated transport mechanisms.
- Among the omega-3 PUFA associated proteins, those participating in immune pathways of the complement system (C5, CFB, C1QB, and S100A9), the coagulation pathway (F5) and lipid transport pathways (Apo E, Apo CIII, and Apo D) were found associated with clinical outcomes.
- The results of the mediation analysis showed that omega-3 PUFAs might exert a beneficial clinical response through immune pathway proteins, mainly the complement and coagulation cascade.
Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis (open access)
doi.org/10.1038/s41398…
#nutrition #diet #PUFAs #Omega3
doi.org/10.1038/s41398…
#nutrition #diet #PUFAs #Omega3
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