Discover and read the best of Twitter Threads about #PUFAs
Most recents (10)
The findings of this meta‐analysis suggest that combined intake of DHA + EPA is likely to lower triglyceride and non-HDL-c, especially when the dose is more than 2 g/day. 
- Evidence of an approximately linear dose–response relationship for triglyceride and non‐HDL‐C reduction among the general population and especially in populations with hyperlipidemia and overweight/obesity was observed.
- These inverse correlations were more prominent in participants receiving basal lipid‐lowering medications or with pre-existing coronary heart disease, given the intake dose was higher than 2 g/d.
In this one, high intakes of seafood, and particularly small fish rich in n-3 fatty acids, was associated with a lower risk of 10-year fatal and non-fatal cardiovascular disease risk in Greek adults with a mean age of 45.2 years.
- Less than one-10th of the study participants consumed >1 serving of small fish rich in n-3 fatty acids per week.
- Participants who consumed >2 servings per week of seafood had at least 27% decreased risk of developing CVD and 74% lower 10-year risk of dying due to CVD.
In this multiethnic cohort of US women and men free of clinical cardiovascular disease between 45 and 84 years old, consumption of avocado/guacamole was not found associated with levels of inflammatory markers.
- "Our observational study confirms results from smaller studies and clinical trials that although avocados are high in fat, consumption is not associated with increased levels of inflammatory markers...
"...High-fat diets, in general, have been linked to inflammation and a host of other diseases, but not all fatty acids have similar health effects...
More data regarding EPA, its cardioprotective effects, and whether the outcomes of REDUCE-IT were due to the placebo that the control group was taking.
Using an in vitro atherosclerosis model, the study's findings suggest that administration of mineral oil to promote atherosclerosis to a degree sufficient to account for the full benefit observed with EPA treatment in REDUCE‐IT is unlikely.
"Along with other distinct mechanisms, EPA antioxidant properties may contribute to reduced cardiovascular events in outcome trials using IPE compared with n3‐FA combinations, independent of placebo selection."
The findings of this one suggest that central adiposity leads to dyslipidemia, with measures of insulin resistance and sensitivity partly mediating this, and that n-3 PUFAs may moderate the direct path between adiposity and dyslipidemia, reducing the risk for type 2 diabetes.
- This study was conducted in Yup’ik individuals from 10 communities in rural SW Alaska.
- Although Yup’ik people have an obesity and prediabetes prevalence similar to the general U.S. population, the prevalence of type 2 diabetes is relatively rare (∼3%).
The findings of this one suggest that a high adherence to a diet that is rich in protein and unsaturated fatty acids may have beneficial long-term effects on liver fat and lipid metabolism in older subjects.
- An increased intake of protein, total fat, MUFA, PUFA and fiber as well as a decreased consumption of SFAs was achieved in the intervention group.
- Adjusted for baseline intrahepatic lipids, age, sex and BMI change, a reduction of intrahepatic lipids by 33.3% was seen in the intervention group, but the median reduction was not statistically significantly compared to the control group.
The findings of this one suggest that the associations between EPA and DHA and the risk of total atherosclerotic cardiovascular disease and acute major ischemic events may be modest and that an intake of at least 1 g/day might be needed to achieve cardiovascular benefits.
- Study included citizens born in Denmark aged 50–64 years who were followed for a median of 13.5 years.
- Statistically non-significant indications of lower rates of atherosclerotic cardiovascular disease and acute major ischemic events with intake of EPA and/or DHA was found, while no statistical association was observed for ALA.
This systematic review and meta-analysis comes to the conclusion that n-3 PUFA supplementation is likely to lead to very small increases in muscle strength, but it is not likely to confer an impact in muscle mass and function in healthy adults (young and older).
- "Our results are in contrast with the meta-analysis published by Huang et al, who found minor increases in muscle mass and function in the elderly after n-3 PUFA supplementation...
Ref:
doi.org/10.3390/nu1212…
Ref:
doi.org/10.3390/nu1212…
"...The fact that they included measurements of muscle mass based on DXA, bioelectrical impedance analysis, and computed tomography, while we only considered gold-standard measurements... may help to explain the discrepancy between our findings...
This one in individuals at clinical high-risk for psychosis suggests that the beneficial impact of omega-3 PUFAs on clinical symptoms in psychosis is mediated, at least in part, through the complement and coagulation pathway proteins.
- The complement system is a network of proteins that play an important role in host defense and inflammation.
- The coagulation system, you guessed it, is the good ol' system that is made up of blood cells and proteins, responsible for creating blood clots to allow for rapid healing and prevention of excessive bleeding.
In this one, dietary intake of ALA and total omega-3 PUFA were associated with muscle strength and function in older women aged 65–72 years living in Finland.
- Both omega-3 PUFA and ALA were positively and significantly associated with short physical performance battery score, one leg stance, walking speed, and with lower inability to squat to ground.
- ALA intake was positively associated with knee extension force and inversely associated with fat mass.
