Thread by @VietHeartPA

@mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape EPA effect on ASCVD in Japanese pts w/chronic CAD and EPA/AA ratios <0.4, on statins.

🐟EPA 1.8 gm (like JELIS)
🐟EPA baseline 46 ug/mL (JELIS, 96)
🐟All on statins, randomized to control or EPA, no blinding (like JELIS)

#aha22 1/ @AHAScience

@mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape @AHAScience N=2506

🐟interesting drop out rate/protocol deviation, covid era?
🐟LDL-C baseline, similar to reduce it
🐟EPA median 46 ug/mL, higher than reduce it (26), lower than Jelis (96).
🐟hsCRP ~0.40
2/ #aha22

@mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape @AHAScience 1,800 mg EPA
🐟46 ➡️ 145 ug/mL (26➡️150 ug/mL, reduce it)
🐟LDL-C, Trigs, HDL-C no change
🐟hsCRP went down in both
3/ #aha22

@mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape @AHAScience 🐟Respect-EPA estimated 30% RRR. Achieved a 21.5% in 1°, 26.5% in 2° endpts.
🐟NO mineral oil.
🐟Didn’t meet endpoint, underpowered.
🐟Achieved nearly Jelis-like similar ~20% RRR.
🐟Both groups on statins and LDL-C 80 mg/dL.
4/ #aha22

@mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape @AHAScience Nearly 20 years later in a population on statin, JELIS results are confirmed: 19-21% RRR w/ EPA 1800 mg.
🐟hsCRP similar
🐟effect in reduce-it, real. Magnitude🤷🏾‍♂️. Probably 15-20% RRR
🐟AF real
🐟 PCSK9I RRR is 15% 😉
5/5 #aha22 #epa #om3