Thread by @rheum_cat

More work from the @bu_bmc_rheum group & collaborators in #OA using data from #MOST

#ACR22

@BU_BMC_Rheum Abs 1912 @profdeepakkumar

❓Is altered facilitatory and inhibitory nociceptive functioning is related to lower physical activity in people with knee OA?

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@BU_BMC_Rheum @ProfDeepakKumar Need a pain sensitization refresher?

https://twitter.com/Tuhina_Neogi/status/1458112558850875394?s=20&t=itZMZw_JQcXtOohBt93JnQ

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@BU_BMC_Rheum @ProfDeepakKumar In this study heightened ascending facilitatory nociceptive signaling was related to ⬇ physical activity and activity intensity

Why is this important? Being able to address pain sensitization in people with knee OA ➡improve physical activity

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@BU_BMC_Rheum @ProfDeepakKumar Abs 1920 from @kecostello

This study is an amazing combination of #biomechanics #MachineLearning #CausalInference

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@BU_BMC_Rheum @ProfDeepakKumar @kecostello 🏥Outcome: knee replacement (KR) at 8 yr f/u

🚶Data collected: demographics, clinical, accelerometry

💻ensemble machine learning approach was to predict the outcome

Model performance assessed with AUC

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@BU_BMC_Rheum @ProfDeepakKumar @kecostello From the ML models ➡ top 10 predictors of knee replacement

Then:📉📈 G-computation to estimate the marginal risk differences of these influential predictors on risk of KR

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@BU_BMC_Rheum @ProfDeepakKumar @kecostello Results figure: Marginal risk differences for knee replacement by 8-year follow-up

Interpret as: the difference in risk of KR per 100 knees in the given category compared to the referent category

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