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Dr Elisa Perego Profile picture
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Dec 1 • 6 tweets • 2 min read
Yes. We knew covid was a disaster in the making, and cardiovascular—clotting "bomb" in 2020 and 2021 already— in addition to all additional downstream effects of infection, like organ injury. Wasn't it a mistake and a deranged strategy to let SARS-CoV-2 rip? I say yes
"A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide."

#LongCovid

—2021

ahajournals.org/doi/10.1161/CI…
"we would like to emphasise the risk of associated stroke." [to covid]

"a 7·6-fold increase in the odds of stroke with COVID-19 compared with influenza was recently reported"

"endotheliitis or endotheliopathy [potentially leading to] thrombosis"

—2020

thelancet.com/article/S1474-…
"Recent evidence indicates that a large proportion of deaths from covid can be attributed to cardiovascular disease, including acute myocardial infarction, arrhythmias and heart failure."

—2021

frontiersin.org/articles/10.33…
"Thromboembolism (TE) rates of COVID-19 are high and associated with higher risk of death. Robust evidence from ongoing clinical trials is needed to determine the impact of thromboprophylaxis on TE and mortality risk of COVID-19."

—2020. Still waiting?

thelancet.com/journals/eclin…
"Does sticky blood drive more severe COVID-19?

signs of blood coagulation were increased in severe COVID-19 patients making the blood on these patients particularly sticky and therefore prone to clotting"

—2020

ndorms.ox.ac.uk/news/blog/oxim…

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More from @elisaperego78

Dr Elisa Perego Profile picture
Dec 3
There is a huge convergence of interests in presenting #LongCovid as a "fatiguing syndrome" and some "vague symptoms". This is not the case: Long Covid comes with prolonged dysfunction and injury across multiple organs and body systems. This includes the cardiovascular system
#LongCovid can affect basically all systems and organs, although with variability across individuals: liver, lung, kidney, immune system, gastrointestinal tract, blood vessels, endothelium, heart, nervous system and brain, just to name a few. We know this since 2020 and 2021
There is a huge amount of scientific evidence on acute and #LongCovid which are/is among the most studied diseases in human history. Anyone speaking of a "mysterious" disease is wrong, or not up to date with the evidence. Covid has massively accelerated research in biomedicine
Read 5 tweets
Dr Elisa Perego Profile picture
Dec 2
"They have fever, dry cough, sometimes violent. The little ones, up to 1 year, may have bronchiolitis and need oxygen. We hospitalize the most severe."
Lombardy's pediatric emergencies, Italy, are overwhelmed by children with respiratory infections.
milano.corriere.it/notizie/cronac…
"Our structure is under duress. We have an average of 90 daily admissions at our emergency"
—Giuseppe Bertolozzi, Director of Emergency at the De Marchi hospital (Policlinico). Milan and other Lombardy cities are experiencing a severe wave of respiratory diseases in little kids
The Buzzi hospital, Milan, had 144 requests for help in the last 24 hours, 46 of which were for a yellow code, i.e. for "moderately severe cases—this puts a lot of pressure on us, we can't do our best"
—Gian Vincenzo Zuccotti, Director of Emergency and Pediatrics at Buzzi
Read 6 tweets
Dr Elisa Perego Profile picture
Dec 2
Looking forward to talk about #LongCovid at the PANSOC
—Centre for Research on Pandemics & Society— webinar series @CASOslo on 16 March 2023
I will speak about “Long Covid: history, research, future challenges.” Thanks @jesdimka for the kind invitation

uni.oslomet.no/pansoc/
A lot of other interesting talks in the spring PANSOC webinars for those interested in present and past epidemics/ pandemics, epidemiology, and human health across different societies and periods @jesdimka

In my talk, I will address the rise of #LongCovid as an international patient-led research and advocacy movement in 2020— the latest research on the disease— and the role of Long Covid in a reassessment of viral-onset diseases and sequelae like #longSARS and (pandemic) #longflu
Read 6 tweets
Dr Elisa Perego Profile picture
Dec 1
If you see tweets by prominent people saying they tested positive, their covid is mild, and they're working from home, please consider: elite people have access to "tools" like top care many of us don't have. Also, covid can get worse with time: one reason why we say #LongCovid
Elite people and the very rich will have a very different covid experience than me, and you, and marginalised communities. They have fast access to antivirals and other early interventions. They have sick pay, or they're so rich they can just afford not working and rest
They have, most likely, their own home in affluent neighbourhoods, so they can modulate their risk for, and avoid, early reinfection, if they want to. They have optimal access to medical care.
Read 7 tweets
Dr Elisa Perego Profile picture
Nov 28
"In the past month we found a 30-fold increased incidence of Kawasaki-like disease. A similar outbreak of [severe] Kawasaki-like disease is expected in countries involved in the SARS-CoV-2 epidemic"

—13 May 2020—data from Bergamo—Italy @TheLancet

#MISC

thelancet.com/journals/lance…
Some early pandemic history. This in the top @TheLancet journal from May 2020 is a first description of the severe, sometimes fatal multi-inflammatory syndrome seen in children weeks after SARS-CoV-2 infection — later known as MISC or PIMS.
"Children diagnosed after the SARS-CoV-2 epidemic began showed evidence of immune response to the virus, were older, had a higher rate of cardiac involvement, and features of MAS. The SARS-CoV-2 epidemic was associated with high incidence of a severe form of Kawasaki disease."
Read 12 tweets
Dr Elisa Perego Profile picture
Nov 28
I will have to repeat this again. We knew covid and #LongCovid had a strong cardiovascular and endothelial component in 2020 and 2021 already. A lot of work on proving this, and raising the alert, was done by patients and advocates. It's published and recorded on many platforms.
Medical professionals and health bodies trying to gloss over this, and to suggest we've just discovered #LongCovid and covid have a severe cardiovascular impact: please do better. Letting SARS-CoV-2 rip was a severe error. Letting millions with no care was a severe error.
There was also emerging, very strong evidence published already in early 2020 about the pathophysiology of covid. This research clearly showed the devastating impact of the disease across the human body. Covid is not a "cold." Never was. Never been.
Read 4 tweets

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