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Dec 2 • 7 tweets • 4 min read
It is 100% clear #MicroClots & endothelialitis are central to #LongCovid pathology. Period.

What’d be great is if #MedTwitter could express outrage on how we’re not moving this research fast enough — rather than scathing patients trying to help themselves time.com/6238147/microc…
“the next step is to determine whether the amount of #MicroClots in a person’s body correlates with their symptom severity. @PutrinoLab lab has already gathered some unpublished data that suggest extensive clotting is linked to increased cognitive impairment”
“@resiapretorius believes leading hypotheses about #LongCovid are interconnected. She posits viral remnants may damage cells that line blood vessels, prompting the formation of inflammation & #microclots, which could in turn make the immune system attack itself. ‘It’s connected’”
“If we can modulate any part of that cascade with therapeutics,” @PutrinoLab says, “people are [hopefully] going to start to feel better.”

I agree! If you address one part of the cascade (downstream or upstream) you give the whole system better chance to rectify everything else.
Note the screenshot above is not from the article — it’s from this blog here:
For all the reply guys about to come in with: “It’s a downstream effect from the root cause! You need to treat THAT!”

Sure, but we’re talking about a diagnostic my friends, a biomarker, a blood test, proof — It’s important to wrap our heads around how monumental that is.

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More from @loscharlos

charlos Profile picture
Dec 3
If you're not willing to acknowledge that right now your government has adopted a policy of unmitigated spread — knowing it will sacrifice millions of lives to #LongCovid — as cost to "return to normal", then you have lost all of your humanity.
All of it. No exceptions.
This is one of the greatest scandals in modern history, and if you think those suffering are going to go down silently, we've got news for you.
Read 5 tweets
charlos Profile picture
Dec 2
“We’ve identified 2 types of #LongCovid: Short LC (<six months) & long LC (>six months) — Treatment for short is 4-8 weeks, chances of recovery are great. Long you need treatment 4-6 months.”

“You can think about it like a stroke — if you get there too late damage might be done”
Further notes treated nearly 400 patients, 5 haven’t responded — & has had two bleeds — less than 1%.

Regardless of your thoughts on triple therapy, it’s likely the longer we’re sick the harder we are to treat & early treatment will end up being critical.

We need treatment NOW
Thank you @gezmedinger & @doctorasadkhan for this video — this entire series was excellent. It’s urgent they we get a clinical trial on this #LongCovid therapy.
Read 4 tweets
charlos Profile picture
Nov 25
“#LongCovid has taken to new heights a medical conflict that shows up with cancer and other dire diagnoses: the tension between the desire for evidence and the pressing needs of patients who are suffering.”
washingtonpost.com/health/2022/11…
“Government-sponsored and government-funded mechanisms are designed for incremental innovation — for steady and safe discoveries,” said @PutrinoLab, director of rehabilitation innovation for Mount Sinai Health System in New York.
“Months-long waits at #LongCovid clinics combined with the sluggish pace of research have left vulnerable patients clamoring for immediate care as manufacturers bring novel remedies to market, often with little data behind them.”
Read 13 tweets
charlos Profile picture
Nov 24
We should be doing this exact test & process on #LongCovid immediately
“One of the really good test for a #LongCovid is endothelial dysfunction with a flow-mediated dilation or EndoPAT test. Normal dilation is around 30% & LC patients are around 7%” - Dr Jaco Laubscher talking to @gezmedinger & @doctorasadkhan
Really interesting accounts in this thread for EndoPat testing for #LongCovid & #MECFS

@ahandvanish @MichaelPelusoMD @PutrinoLab @VirusesImmunity @MVGutierrezMD @calirunnerdoc @TraceySpicer @LekshmiMD @jencurtinmd @drclairetaylor @drschweig @WesElyMD @zalaly @microbeminded2
Read 4 tweets
charlos Profile picture
Nov 24
“It seems quite likely that #LongCovid is a significant part of why the labor market is currently so tight: it has forced people out of the workforce, plunging them into financial turmoil, which is making it harder for employers to find workers.” talkingpointsmemo.com/feature/long-c…
“Still, it was her dream job, and she loved it.. But Finley hasn’t been able to go out on a single dig, or even a delivery, since early 2020. She contracted COVID that March, in the first wave of the pandemic, and nearly three years later her symptoms still haven’t resolved.”
“Data suggests that millions of Americans now find themselves in a similar situation..

..Like Finley, some sufferers have been left so impaired that they’re no longer able to work, or at least not in the same job or under the same conditions that they used to.” #LongCovid
Read 17 tweets
charlos Profile picture
Nov 23
“Researchers found 95% of #LongCovid sufferers have experienced some form of stigma, while 76% reported experiencing it ‘often’ or ‘always’”.

Think you don’t know anyone with Long Covid? You absolutely do — they just don’t want (or need) to tell you. independent.co.uk/news/uk/covid-…
“Some 61% of people said they were very careful who they tell about their condition, with around one third (34%) of respondents regretting telling people about it.” #LongCovid
The participants were asked if they had experienced “enacted stigma”, where they have been directly treated unfairly because of their condition.”
Read 10 tweets

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