🟢#PreTest Q 3️⃣
📊 Pt treated w/ combo of pembro & lenvatinib for mRCC develops grade 3 diarrhea. How might you diagnose which drug is causing this toxicity?
🟢#PreTest Q 4️⃣
📊Pt treated w/ combo of cabo + nivo develops G3 HTN. Cabo therapy is held & pt receives anti-hypertensive medication & BP recovers to baseline. At what dose can cabozantinib be restarted?
• • •
Missing some Tweet in this thread? You can try to
force a refresh
📢@ASCO is only a few days away & we really wanted to put out our top abstracts to👀for
🙏note - we viewed several thousand titles - so we definitely may have missed some‼️
👉And these are not in any particular order
✅But enjoy, RT, and reply😀
#TumorBoardTuesday#ASCO2022
"Emerging"🎯💊
✅Dr. Jones👨🏫the Ph2 FAKTION trial of fulv/capi vs fulv/placebo for Breast Ca
➡️Capi⬆️mOS by 6 mos
➡️This⬆️jumped to 19 ms if the tumor harbored PIK3CA or AKT1 activating OR PTEN inactivating🧬mutations
🔎Breast Ca Oral Abstract # 1005
#TumorBoardTuesday#ASCO2022
"Emerging"🎯💊
✅Dr. Rixe👨🏫PhI data4⃣OBT076, an ADC🎯the CD205/Ly75 Ag - a receptor⬆️on immunosuppressive dendritic cells
➡️1⃣PR & 6⃣SD out of 2⃣0⃣pts
➡️Near CR in 2⃣pts who then had pembro
🤔Why wasn't☝️more than a poster❓
🔎Abs 3028, Poster 20
Take🏠messages:
⬆️ options to tx HER2+ #MBC
✅T-DXd >T-DM1 in 2L setting (DESTINY BREAST-03)
✅Beware ADC tox- think 🫁pneumonitis & GI w T-Dxd
✅ADC design is 🗝:
➡️Need to consider DAR, linker, ability to cause ADCC
✅ADC + IO= open ❓
Take🏠messages (cont’d):
✅T-DXd active against brain mets (TUXEDO-1)
✅Triplet (tucatinib, cape, tras) also active in brain mets
✅Next up: T-DXd in HER2 LOW- trials ongoing
Take🏠messages: #CRC 🚫one disease!
✅Diff 🧬subtypes that define tx sensitivity
✅BRAFv600E is bad–but may be ⬆️sensitive to IO w MLH1 meth
✅Neoadj tx: 🦊FOXTROT= poss benefit, depends on subgroup
✅Keynote177: IO= way to go in dMMR!