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Giovanni Landoni, MD Profile picture
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Jan 1 • 5 tweets • 5 min read
in 1932 #oxygen was delivered subcutaneously!
with non-negligible success

#ARDS #ecmo
1/
physoc.onlinelibrary.wiley.com/doi/epdf/10.11…
In 1933 #oxygen wad delivered through the peritoneal cavity and stomach
with non-negligible success

#ARDS #ecmo
2/
physoc.onlinelibrary.wiley.com/doi/pdf/10.111…
In 1935 #oxygen was delivered intravenously
with non-negligible success

#ARDS #ecmo
3/
physoc.onlinelibrary.wiley.com/doi/pdf/10.111…
#Oxygen was recently delivered by lower intestinal tract

PaO2 was 40 vs 63 mmHg in sham and treatment group!! (pH and CO2 were similar)

Intestinal gas ventilation was effective for systemic oxygenation and in mitigating lethal hypoxia

4/
pubmed.ncbi.nlm.nih.gov/35590139/
New technology (or a combination of the above techniques) might reach clinically relevant effects in delivery #oxygen through alternative routes in the next future

Which one would you bet on?

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More from @giovannilandoni

Giovanni Landoni, MD Profile picture
Jun 12, 2021
We identified all sudden cardiac death occurring in Italian youngster (1-35y) and reported by media 2010-2015 under the leadership of @sozi81
pubmed.ncbi.nlm.nih.gov/33638776/
#Eriksen @IntensiveBot
1/ Image
Autopsy data were available in 100/132 (75.8%) cases: an extra cardiac cause was identified in 20 (20%). Among the 61 cases with a cardiac diagnosis, 21 (34%) had hypertrophic cardiomyopathy.
2/
Among the 19 (19%) victims without structural abnormalities, molecular autopsy identified pathogenic variants for channelopathies in 9 cases. Ten (10%) victims had no identifiable cause
3/
Read 7 tweets
Giovanni Landoni, MD Profile picture
Jul 27, 2020
1/
 I want to thank all my colleagues for the wonderful #COVID19 research they published during these months: >200 PubMed-indexed articles from @SanRaffaeleMI @SRAnesthesiaICU @MyUniSR @azangrillo
I’ll summarize few of them in this thread.
2/
 In February, before the start of #COVID19 in Europe, we suggested the use of helmet to deliver #CPAP #NIV in emergency departments. This can be a key issue to prevent future spread of respiratory pandemics in emergency departments.
thelancet.com/journals/lance…
3/
 As soon as #COVID19 spread in Lombardy we helped other centers to manage their worst patients: 39 patients from other centers were admitted in our ICUs. The H was reshaped to cope with the new situation. The manusc cited 38 times in the first 4 months.
Read 19 tweets

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