Thread by @PatientPersists

Hopes for the new year: #LongCovid trials I'm excited about

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1) #CPCOV03

Host directed antiviral, induced autophagy

I wrote a thread about it here

https://twitter.com/PatientPersists/status/1597850638108758017?s=20

2) #TVG489

Allogenic CAR T cells

These will hopefully be able to clear infected cells, if T cell evasion by SARS-CoV-2 (via MHC I downregulation) can be overcome

labiotech.eu/trends-news/te…

3) #Ampligen

Immune stimulator with a long history..
healthrising.org/blog/2022/10/1…

I don't expect it to be a cure.

Instead, what I'm looking for (with every antiviral therapeutic) is a positive signal that it could increase the effectiveness of an antiviral cocktail

4-6) Three Paxlovid trials

Mixed feelings about this. With limited funding, this seems very inefficient. Still, it has to be trialed to confirm anecdotal evidence of some (temporary) effects

One of the trials has 1700 participants, too much imo

Also: only 15 days

I'm happy though that at least 1 of the trials will use the Simoa assay to assess virus in the blood (viremia)

And another will track immunological changes (by @VirusesImmunity )

Auto-antibody therapies

7) #BC007 obviously. Very curious about this. Sounds too good to be true, but I'd be happy to be surprised

8) #RSLV132
clinicaltrials.gov/ct2/show/NCT04…

9) #Efgartigimod

https://twitter.com/42soho/status/1598343648416075777

(There are probably some other promising trials I'm unaware of, but I'm primarily following viral persistence literature & therapeutics)

There are a couple of obvious drugs missing:

Peginterferon #Lambda, an Immunostimulatory drug with efficacy in acute covid and long-term safety (48 weeks!!)

#Remdesivir and associated RdRp inhibitors #VV116 and #obeldesivir (#GS5245)

#Ensitrelvir 🇯🇵s Mpro protease inhibitor

And of course monoclonal antibodies with cytotoxicity against infected cells!

There's a whole lot more to be trialed that I haven't mentioned..

But my biggest hope for 2023:
that we'll see/create more pharma buy-in and philanthropic support for a Long Covid Trials Platform!