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Dr. Gustavo Aguirre-Chang Profile picture
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Jan 8 • 10 tweets • 6 min read
VENOUS BLOOD GASES (VBG)
In addition to
LongCOVID
Post Vax
They are useful in
ME/CFS
Fibromyalgia
POTS
Lyme
EBV
Bartonella
Arthritis
Sjögren's
Lupus
Ehlers-Danlos
Restless Legs
Fasciculations
Stiff Person
Adrenal Fatigue
Thyroiditis
Mitochondrial Dysfunct.
researchgate.net/publication/35… Image
INVERSE CORRELATION WITH MICROCLOTS
We observed that
the lower the value resulting from the
Venous Oxygen Saturation: SvO2
There is a greater amount of #Microclots
and a greater improvement is obtained when giving treatment with
Antiplatelet
Fibrinolytics
Drugs against Viral Load
Venous Blood Gases: VBG
it is a low cost blood test:$18-40
It can be performed in most Hospitals in the world
The results can be given in a few hours
In Australia can be ordered by any GP under Medicare

And why is it still not used in North America/Europe?
Despite its low cost
it's been 2 years
and the Health Systems of America and Europe
have not yet considered covering this VBG analysis
In the UK there are a few hospitals where it can be done
but as a private patient
this according to what a patient wrote:
We have observed
than those who score more than 8 points in the HHM Test
had some degree of decrease in Venous Saturation
And the #LongCOVID patients who had
shortness of breath
and discomfort or pain in the middle of the chest
often had less than 40% SvO2
researchgate.net/publication/36… Image
WE DESCRIBE A NEW CAUSE OF HYPOXEMIA
DUE TO INCREASED OXYGEN CONSUMPTION AT THE VASCULAR LEVEL
BEFORE ITS EXTRACTION INTO THE CELLS
ASSOCIATED WITH CHRONIC ENDOTHELITIS
due to persistent intracellular infection
that affects the vascular walls & blood cells
researchgate.net/publication/35… Image
In #LongCOVID
There is an inverse correlation
between the SvO2 level
and the Viral Load
Severe hypoxemia in venous blood
tells us that there is
a high Viral Load
There is an active Persistent Infection
that affects the vessels
and blood cells
without significant tissue compromise
Since the main cause of #LongCOVID or #PACS
is
the Viral Persistence

The main objective of the treatment is
Reduce the Viral Load

Antiplatelet and Fibrinolytic drugs help
But to achieve healing
Effective Drugs are required
Against Viral Load
Such as TDF:
researchgate.net/publication/36…
Similar to #LongCovid
The main cause of
ME/CFS
Fibromyalgia
POTS
R. Arthritis
Sjögren's
Lupus
They are Persistent Intracellular Infections
that affect the blood vessels

The main objective of the treatment is
Reduce the Viral/Microbial Load
See details in:
researchgate.net/publication/36… Image
A big drawback is the fact that
there is very little knowledge of the analysis
of Venous Blood Gas VBG
by the majority of health personnel

This causes it to minimize or
its usefulness is denied
And it is also often confused with the Arterial Gas ABG
which is almost always normal

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More from @Aguirre1Gustavo

Dr. Gustavo Aguirre-Chang Profile picture
Jan 8
In this study
in addition to reporting the longest persistent infection to date:
505days
They describe a case that they call
‘Occult’ infection
It is a case that gave Negative in its PCR several times
and developed COVID symptoms again after several months
In this case
sequencing of the virus genome showed that infection
was caused by the Alpha variant
which had already been removed from the UK by that date
indicating that the virus had persisted latent in the patient for several months
and the PCRtests did not detect it
#LongCOVID
Very often PCR of nasal and pharyngeal secretions
they give False Negatives in #LongCOVID #PACS
The problem is that most assume that a Negative PCR of the nose or pharynx
Indicates that there is no virus in the heart, intestines and other parts of the body
Read 4 tweets
Dr. Gustavo Aguirre-Chang Profile picture
Dec 30, 2022
UNDIAGNOSED VIRAL PERSISTENCE
IN 32.5% OF PATIENTS UNDERGOING BARIATRIC SURGERY
All had Negative PCR before Surgery
They were unaware they had a Persistent Infection due to SARS-CoV-2
One part had more than 1 year since infection
doi.org/10.1007/s11695…

Are #UndiagnosedLongCOVID
100% of the PCR tests were False Negatives
If the infection persists
the virus will no longer be found in secretions from the nose & throat
It is located inside the cells
Viruses cause Intracellular Infections
PCR cell/tissue samples required in #LongCOVID
researchgate.net/publication/34…
The patients operated on in whom it was performed
the finding of
undiagnosed persistent infection
had on average 274 days from the onset of SARS CoV-2 infection
and surgery

61.5% were vaccinated (>2 doses Pfizer)
No differences were identified between vaccinated and unvaccinated
Read 4 tweets
Dr. Gustavo Aguirre-Chang Profile picture
Dec 27, 2022
VIRAL PERSISTENCE
IT IS THE MAIN CAUSE OF MYOCARDITIS IN #LONGCOVID
In 85.7%(12/14) of Endomyocardial Biopsies
persistence of up to 18 months of SARS CoV2 was detected
It was identified in Cardiomyocytes,Endothelium,Macrophages
Also Anticardiac Antibodies
onlinelibrary.wiley.com/doi/10.1002/cl…
None of the 14 cases had severe respiratory failure or evidence of cardiac injury during Acute COVID
In all of them Myocarditis only manifested itself after the acute phase of COVID
In #LongCOVID #PACS
This was diagnosed 2 to 18 months later
and confirmed by Endomyocardial Biopsy
In 2of the cases
47year-o. women
Myocarditis symptoms appeared only after vaccination
this means
who were carriers of a latent infection
Authors point out:
This suggests a triggering (resolving) role of the vaccine
when administered after an infection
that can remain asymptomatic
Read 5 tweets
Dr. Gustavo Aguirre-Chang Profile picture
Dec 27, 2022
PERSISTENCIA VIRAL
ES PRINCIPAL CAUSA DE MIOCARDITIS EN #LONGCOVID
En el 85,7% (12/14)
de las Biopsias Endomiocárdicas se detectó persistencia de hasta 18 meses del SARS CoV2
Se identificó en Cardiomiocitos, Endotelio, Macrófagos
Además Antic.Anticardiacos
onlinelibrary.wiley.com/doi/10.1002/cl…
Ninguno de los 14casos tubo insuficiencia respiratoria grave ni evidencia de lesión cardíaca durante el COVID Agudo
En todos, la Miocarditis recién se manifestó después de la fase aguda de COVID
Esta fue diagnosticada 2 a 18meses después
y confirmada por la Biopsia Endomiocárdica
En 2de los casos
mujeres de 47años
los síntomas de Miocarditis aparecieron solo después de la vacunación
es decir
eran portadoras de una infección latente
Autores señalan:
Esto sugiere un papel desencadenante de la vacuna
cuando se administra después de una infección asintomática
Read 4 tweets
Dr. Gustavo Aguirre-Chang Profile picture
Dec 16, 2022
PAXLOVID versus TRUVADA
FOR CHRONIC COVID #LONGCOVID #PACS
For costs and side effects
and as months of treatment are required
Win Truvada
containing
Emtricitabine FTC+
Tenofovir Disoproxil FumarateTDF
One could start with Paxlovid and continue with Truvada
PROTOCOLS FOR CHRONIC COVID #LONGCOVID

I. INTENSIVE PHASE AGAINST VIRAL LOAD
It includes:
1.FTC/TDF (Truvada). The alternative is to start Paxlovid for 10-25 days and then continue with FTC/TDF
2. IVM or Liposomal Artemisinin or Artesunate
3. ECGC or Nitazoxanide or Ozone 10pass
The objective of the INTENSIVE PHASE in CHRONIC COVID #LONGCOVID
is to minimize the Viral Load
Lasts 1-2months
Then follows the Maintenance Phase
whose objective is to avoid the Relapse/Reactivation of the infection
The number of drugs is reduced
Lasts 3 to 8months
depending
case
Read 5 tweets
Dr. Gustavo Aguirre-Chang Profile picture
Nov 21, 2022
ASYMPTOMATIC OR LATENT PERSISTENT INFECTION IN CHILDREN.

SARS COV-2 WAS DETECTED IN BIOPSIES OF TONSILS OR ADENOIDS
IN 25% OF ASYMPTOMATIC CHILDREN
None had experienced signs or symptoms

Authors point out:
lymphoid tissue may be a Reservoir of SARS-CoV-2
doi.org/10.1016/j.bjor…
It had already been identified that the Biofilm or Dental Plaque harbors SARS CoV-2
To this is added the Tonsils and Adenoids in children
Therefore, it is confirmed that the oral cavity is a potential reservoir for the virus
There are Asymptomatic Carriers
In #LongCOVID
For Viral Persistence,
for having Drug-Resistance
we indicate 3 or more medications or supplements with effects against Viral Load
In addition
any infectious focus at the oral level must be eliminated by the Dentist
and mouthwash is indicated
Read 5 tweets

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