📍N=1,846 pneumonia patients w versus w/out COVID
📍COVID didn’t “invent” a new lung disease
📍We freaked out saying vents needed to be so different
📍Docs erred as we deviated from our evidence-based
6/ Based on hype & speculation of how “different” covid pneumonia was, patients all over the 🌎 got (& still get) DIFFERENT care 20 years of research had taught us.
👇In our COVID-D study, we showed VERY heavy sedation w benzos & almost no family.
Her excellent neurologist feels her negative work-up, young age, speed of demise, temporal onset in relation to COVID all fit LongCOVID-related brain dysfunction & not a pattern of Alzheimers.
They want to share
3/ Husband through tears: “I want my wife back.”
Her Description – “I walk down the hall & see pictures of family & trips. I feel like a ghost because I don’t remember. My husband cries because I seem gone to him.”
“I’m trying to figure out who Barbara 2.0 is going to be.”
📌7k COVID+ healthcare workers followed in clinic
📌Data show being more vaxxed (3 or 4 shots) & <2 COVID infections were both predictive of better recovery at 1 mo
📌But there are limitations
2/ These data explain how the COVID virus places our bodies at risk for macro (large) blood clots in acute dz (which we see often), brain disease due to down-stream micro-clotting, and possibly later cardiovascular dz.
What did these London investigators find?
3/ Taking blood from 2 UK SARS CoV2 studies…
📍They compared COVID🩸(N=62 mild/mod dz) to normal controls
📍Then conducted genetic, metabolic & functional assays
👀 Look how different gene expression was (color difference) in COVID vs. HC (healthy control) pts
✔️COVID is vascular disease
✔️Diabetes is a vascular disease
✔️COVID causes a chronic immune disorder
✔️Diabetes is a chronic immune disorder.
✔️A diabetes drug with immune mechanisms may help both in unrelated ways
3/ This meta-analysis of 9 studies of ~40m people found 50% increased risk of DM type 1 (insulin dependent) & 70% higher risk of DM type 2 across age groups & sex - plus way more risk than general upper respiratory infections.