WesElyMD Profile picture
Jan 16 8 tweets 5 min read
1/🧵COVID & Death: #JAMA
 
📍N=1,846 pneumonia patients w versus w/out COVID
📍COVID didn’t “invent” a new lung disease
📍We freaked out saying vents needed to be so different
📍Docs erred as we deviated from our evidence-based

Why should YOU care?
 
bit.ly/3QIp2Tl
2/ COVID is a very long pneumonia process, but we exacerbated it…

This graph shows that Death occurs similarly, but COVID #death takes longer (10 vs. 7 days).

Time to discharge alive is twice as long (10 vs. 5 days) in COVID vs non-COVID pneumonia.

We caused a lot of this 😞
3/ Let’s breaks outcomes down by O2 levels…
 
At 90 days, death rates were same in COVID & non-COVID pneumonia for patients w moderate & severe low O2 levels

COVID was NOT a predictor of more death or liberation from the vent or hospital (after matching & multivariable models)
4/ At the beginning of the pandemic, gurus speculated this was a DIFFERENT lung disease.
 
Look at these 6 physiology graphs.
 
Does anything look different to you?
 
Why does this matter to you and your family now?
5/ It matters because you’ll have to advocate for your spouse or best friend or child.

In this piece I unpacked ways, you can speak up if they get sick and land in the ICU.

Let’s keep going w more data…there’s more…

bit.ly/3DhC6Xe
6/ Based on hype & speculation of how “different” covid pneumonia was, patients all over the 🌎 got (& still get) DIFFERENT care 20 years of research had taught us.
 
👇In our COVID-D study, we showed VERY heavy sedation w benzos & almost no family.
 
It was ANTI-MEDICINE
7/ This is an excellent 🧵 by @MiscSusan explaining a lot of how we got off course by acting too quickly on bad intel…
8/fin
How do we rehumanize care so it’s safe again?

✔️ We made errors
✔️We abandoned proven comprehensive #A2Fbundle safe care
✔️ What matters is what we do next

Teams, return to basics💥
Families speak up!💥

bit.ly/2YF64G2

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More from @WesElyMD

Jan 17
1/🧵 Real-World Long COVID
 
🔹She got COVID Oct 2020
🔹59 y/o walked 5mi 4x /wk
w no prior cognitive problems
 
🔹“I got better but 4 mo later my memory faded. I struggled.
🔹HR came after me, ‘You can’t do your job.’”
 
Husband: “I want my wife back!”

(Pics & story w perm) Image
2/ Could her new #dementia be unrelated to COVID?

Maybe, but…
 
Her excellent neurologist feels her negative work-up, young age, speed of demise, temporal onset in relation to COVID all fit LongCOVID-related brain dysfunction & not a pattern of Alzheimers.
 
They want to share Image
3/ Husband through tears: “I want my wife back.”
 
Her Description – “I walk down the hall & see pictures of family & trips. I feel like a ghost because I don’t remember. My husband cries because I seem gone to him.”
 
“I’m trying to figure out who Barbara 2.0 is going to be.” Image
Read 10 tweets
Jan 6
1/🧵Risk Factors for Long COVID❓
 
📌7k COVID+ healthcare workers followed in clinic
📌Data show being more vaxxed (3 or 4 shots) & <2 COVID infections were both predictive of better recovery at 1 mo
📌But there are limitations

Here are my critiques…
 
bit.ly/3VPt0ul ImageImage
2/ Definitions
Cases: +COVID test & symptoms c/w CDC definition at 1mo N=1.9k (27%)

Controls: +COVID test & resolution at 1mo N=5.1k (73%)
 
Of those w symptoms at 30 dys, 51% had 3 or more👇

IMO the @WHO 90 dy cut-off is more specific & meaningful for #LongCOVID Image
3/Logistic regression found 2+ COVID infxns ⬆️ risk of #LongCOVID by 27% & 3 or 4 vax shots ⬇️ risk.
 
I don’t like CDC’s 30 day definition but these data are c/w other studies showing “less infection & more antibodies” are both protective.

CDC vs WHO
bit.ly/3QiinPq
Read 4 tweets
Jan 5
1/🧵 Fake Science is BIG Business💰💰

What’s a “paper mill?

📍>500 “fake science” papers are being retracted
📍“Paper Mills” create made-up papers, trick peer review
📍People pay for authorship to boost academic credentials

Let me explain

bit.ly/3WXnhDx
2/ In this example👇…

manipulated peer-review was proven & >500 papers are being pulled! 🤯

H/T Neuroscientist @Schrag_Matthew explained:

“It's a bad look for Wiley!”

Investigators found irregular reviewer activity & ‘bad actors’ across publications

bit.ly/3WXnhDx
3/ As a Physician-Scientist at the bedside, it’s maddening & saddening to see people succumb to #misinformation

And then make choices that allow them to fall into severe life-threatening COVID and land in my ICU.

nyti.ms/3VHospA
Read 9 tweets
Jan 3
1/🧵 Our cell’s genes are rewired in MILD COVID 🧬
 
Stunning data in @Nature
 
White Cells (monocytes) switch gene expression from an established innate immune profile to a pro-clotting signature in COVID.
 
We’re immunocompromised.

Let’s unpack this…
 
go.nature.com/3GeDygW
2/ These data explain how the COVID virus places our bodies at risk for macro (large) blood clots in acute dz (which we see often), brain disease due to down-stream micro-clotting, and possibly later cardiovascular dz.
 
What did these London investigators find?
3/ Taking blood from 2 UK SARS CoV2 studies…

📍They compared COVID🩸(N=62 mild/mod dz) to normal controls
📍Then conducted genetic, metabolic & functional assays
👀 Look how different gene expression was (color difference) in COVID vs. HC (healthy control) pts
 
What’s it mean?
Read 8 tweets
Dec 29, 2022
1/🧵Diabetes is part of Long COVID & a diabetes drug reduces Long COVID⁉️

📌 Studies of MILLIONS show COVID ⬆️ risk of new onset Diabetes by…
📌60%!! 🤯
📌 #Diabetes 1 & 2 are solidly documented components of #LongCOVID

👇 I unpack data & what this means & why should you care?
2/ First, this is fascinating & scary. Check it…

✔️COVID is vascular disease
✔️Diabetes is a vascular disease
✔️COVID causes a chronic immune disorder
✔️Diabetes is a chronic immune disorder.
✔️A diabetes drug with immune mechanisms may help both in unrelated ways
3/ This meta-analysis of 9 studies of ~40m people found 50% increased risk of DM type 1 (insulin dependent) & 70% higher risk of DM type 2 across age groups & sex - plus way more risk than general upper respiratory infections.
 
bit.ly/3G0j4bC
Read 9 tweets
Dec 27, 2022
1/🧵Can a Diabetes drug prevent Long COVID?
 
Most solid data yet of a medication preventing #LongCOVID from quadruple blinded, non-pharma sponsored COVID-OUT trial N=1,125.

A 42% relative ⬇️ in clinician diagnosed LC was seen (10.6% down to 6.3%).
 
bit.ly/3jvvKj4
2/ Metformin’s success (1 LC prevented for every 23 pts treated) could save millions from suffering.

<$1 per course = very cost effective.
 
Too good to be true?  Maybe but very solid science.

Let me unpack a bit more…

bit.ly/3jvvKj4
3/ This trial had 6 groups of patients because 3 meds (metformin/fluvoxamine/ivermectin) were randomized vs. placebo.
 
The other drugs showed no benefit toward Long COVID reduction.
 
Metformin also looked good for Acute COVID.
Read 9 tweets

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