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Jan 18 • 11 tweets • 4 min read
This one delves further into the cardiometabolic impact of body fat distribution, finding associations between visceral, abdominal subcutaneous, and gluteofemoral adipose tissue volumes at scale and risk of type 2 diabetes, and coronary artery disease. Image
This is not the first study of this group in this subject. They have done some previous, related, and very interesting work on the matter:


- The intention was to quantify visceral, abdominal subcutaneous, and gluteofemoral adipose tissue volumes at scale using machine learning and data from the studies mentioned above, in order to determine associations with type 2 diabetes and coronary artery disease.
- To measure specific fat depot volumes at scale, they used BMI-adjusted metrics for each fat depot (visceral, abdominal subcutaneous, and gluteofemoral adipose tissue volumes adjusted for BMI).
The findings were in line with several other studies:
- The study demonstrated a consistent trend of visceral adipose at scale to be associated with increased risk of type 2 diabetes and coronary artery disease. ImageImage
- Abdominal subcutaneous adipose tissue at scale was found to be largely risk-neutral.
- Gluteofemoral adipose tissue at scale was found to be protective.
Important to note that since the UK biobank is largely consisted of a White, Causasian population that "although our data suggests similar performance of our deep learning models across self-reported ethnicity subgroups...
"...we were underpowered to study disease associations in non-White subgroups."
BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases (open access)

doi.org/10.1038/s41467…

#MetabolicSyndrome #Obesity #InsulinResistance #Cholesterol #Triglycerides #Hypertension #Diabetes

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