#LongCovid is correlated with the #SpikeProtein protein. #Diagnosis
In this study, SPIKE antigen detected most often in 60% of the PASC patients and in > 70% of patients who reported ongoing cardiovascular, systemic, head-eye-ear-nose-throat, and musculoskeletal symptoms.
In this study, SPIKE antigen detected most often in 60% of the PASC patients and in > 70% of patients who reported ongoing cardiovascular, systemic, head-eye-ear-nose-throat, and musculoskeletal symptoms.
If viral reservoirs persist in the body of PASC patients, why do we not also detect N in more patients? Active viral reservoirs could cause PASC symptoms, but circulating spike may also give rise to symptoms.
Although spike does not instigate a cytokine storm in PASC patients, spike alone has been shown to induce dysfunction in pericytes, vascular endothelial cells, and the blood–brain barrier
the presence of circulating spike in PASC patients up to 12 months after diagnosis suggests that SARS-CoV-2 viral reservoirs may persist in the body.
There are likely many overlapping immunological and inflammatory phenomena contributing to PASC and the detection of spike cannot alone confirm the presence of active viral reservoirs.
However, if our finding can be validated in a larger cohort, it would provide strong support for the use of spike as a biomarker for PASC, making it easier to identify patients and assess treatment strategies.
Why is #SpikeProtein not being studies as a biomarker for #LongCovid ? academic.oup.com/cid/advance-ar…
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