The CDC's #ACIP meeting on #mpox/#monkeypox is going on. Some interesting stats! Cases have remained overwhelmingly among men who have sex with men. Cases in kids have been extremely rare. Vaccine uptake has been racially inequitable. 🧵⬇️
The CDC estimates the Jynneos mpox vaccine efficacy based on 9,544 mpox cases among men 18-49 from July 31-Oct 1. Mpox rates were 7.4 times higher than those with 1 dose of the vax and 9.6 times higher than those with 2 doses. No difference based on subdermal vs intradermal. 2/
More mpox stats: 3/
An Israeli study estimated that the Jynneos mpox vaccine reduced the risk of the virus by 86%. 4/
Another study estimated that the Jynneos vaccine was 66% for those fully vaccinated, including 76% of those with no immunocompromising conditions. 5/
Yet another study found the #mpox vaccine was 90% effective among those without immunocompromising conditions. 6/
A New York City study of the #mpox vaccine found it was 66% to 83% effective. 7/
The mpox vaccine is safe according to multiple means of monitoring safety, per the CDC #ACIP meeting.
BREAKING: French researchers estimate the Jynneos #mpox vaccine is 99% effective. Per #CROI2023: of 472 participants in HIV PrEP study, 77 got mpox. Before and after mpox outbreak and July 2022 vaccination campaign, the only factor tied to reduced mpox risk was vaccination. 1/2
The French researchers found that after the mpox outbreak started, the only significant shift in sexual behavior change in the 472 men who have sex with men on HIV PrEP was a reduction in the proportion reporting >10 sexual partners during previous 3 months (45% to 35%). 2/2
@Boghuma analyzed data on military vets and service members, many of whom received the smallpox vaccine between 2002 and 2017. 1,007 were tested for suspected #mpox, 298 tested positive. In this group, vaccination, typically 13 years before, lowered risk 66% to 72%. #CROI2023
I have been subjected to Alejandra Caraballo’s calls for people to blacklist me. She is one of the loudest and most effective voices to silence and intimidate reporters covering pediatric gender-transition treatment.
And how activists will eagerly cut off their noses to spite their faces in service of virtue signaling and maintaining an image of ideological purity amid the battle over pediatric gender medicine. open.substack.com/pub/benryan/p/…
Pete Buttigieg told @BulwarkOnline that if he could do it over, he would’ve worked to get the schools open faster in 2020. In response, @TaylorLorenz denounced him as a eugenicist.
Meanwhile, @DavidZweig’s new book presents an avalanche of evidence indicating that school closures likely did not reduce morbidity and mortality and harmed children. He also demonstrates that there was considerable evidence of the apparent lack of benefit from European nations as early as May 2020.
I interviewed @davidzweig about his book about the folly of the Covid school closures, An Abundance of Caution, for my pod. I drew parallels to the pediatric gender medicine field:
@davidzweig “Today, there is broad acknowledgment among many public health and education experts that extended school closures did not significantly stop the spread of Covid, while the academic harms for children have been large and long-lasting.” nytimes.com/2024/03/18/ups…
The Utah state government commissioned a report on pediatric gender-transition treatment. It comes in at over 1,000 words and concludes that the evidence favorably backs such treatment.
But despite the fact that it bills itself as a systematic literature review, it isn't one.
The authors of the report, from the University of Utah College of Pharmacy, did not register their methodology on PROSPERO in advance as is required for a systematic literature review. Nor did they rate the quality of the evidence as all other systematic reviews of this field have. What's more, their report explicitly takes on faith the claims of authors of treatment guidelines that their own process in developing those guidelines was rigorous. This after the University of York's systematic literature review on such guidelines, published in April 2024, found that all but a couple of such guidelines were of poor quality and not reliable.
Essentially, this report is a narrative review that summarizes the bulk of the research in this field. But it does not seek, like all the actual systematic literature reviews have, to make sense of whether that research is reliable and whether it can properly guide doctors and families in making a solid calculation about the risks vs benefits of these drugs when given to children.
In sum, this report reflects everything that the authors of systematic literature reviews and groups like @SEGM_EBM have been seeking to respond to.
Note also that the bulk of the report's 1,000 pages is taken up by a compendium of abstract after abstract of the studies they considered, or chart after chart breaking them down. So it's not as if the authors actually wrote anything approaching 1,000 pages.
I strongly advise people who think that @AlecMacGillis, who wrote one of the finest Covid-era articles critiquing the school closures, is “lying” about their impacts read @DavidZweig’s scathing new book about the lockdowns, An Abundance of Caution.
Zweig makes a very strong case that there was substantial evidence by spring 2020 that lockdowns did not substantially lower COVID morbidity and mortality. And he further makes a very strong case that the lockdowns harmed kids in myriad ways.
I also suggest people stop and consider that Blooskie is just as toxic as X, but in a kind of mirror image.
This is @AlecMacGillis’ heartbreaking article about how the Covid school closures impacted a small town, and how the lack of them in a neighboring town didn’t seem to lead to worse covid outcomes. propublica.org/article/the-lo…
Helping out young people need not be a zero-sum effort. Accurately observing that boys are falling behind in many respects need not divert attention away from the plight of women and girls. The real problem is when people pit the interests of the sexes against one another. Moira Donegan really should go read @RichardVReeves’ work and stop trying to be so divisive and dismissive about a real and serious problem facing boys and young men.
In fact, Moira's attitude, which is essentially, "Screw those boys, the girls need help," is a pervasive bias that is likely part of the reason why boys are struggling! People look at boys and see the patriarchy and something that needs to be pushed down. This is harmful to everyone in the long run, boys and girls alike.
Also Moira Donegan: She made the "Shitty Media Men" list and paid a six-figure settlement to Stephen Elliott over it after he sued her. washingtonpost.com/media/2023/03/…