Thread by @TactNowInfo

🧵What’s the difference between XBB.1.5 and XBB.1.16 that gives XBB.1.16 an estimated 200% growth advantage over XBB.1.5?

A concerning trend that has been gaining momentum is mutations in the body of the virus instead of the spike.

Even though XBB.1.5 is already avoiding antibodies, the immune system is still alerted to the infection. The mutations in XBB.1.16 could make things worse by messing up the signal that tells the immune system there's an infection. 2/

It may be shutting off the alarm system so the body doesn’t know there is an intruder. This could result in fewer symptoms while it infects immune cells and weakens the immune system, leaving people more vulnerable to infection from other viruses and bacteria. 3/

This may be contributing to the adenovirus & H3N2 surge in India.

”More than 3,000 children have been admitted to hospitals with severe flu-like symptoms”

“The Association of Health Service Doctors warns that the numbers of deaths and cases are likely to be much higher" 3/

The XBB variants are more likely to cause persistent infections raising the risk of diabetes, heart attacks, strokes, GI issues, brain damage, early onset dementia, autoimmune disorders, and a variety of other long-term health issues. 4/

Local media reports put the death toll at more than 100 children. The state’s healthcare system is struggling to cope. Some hospitals' pediatric wards are full.

The “officials” are reporting that this is caused by “two mutated adenovirus strains.”
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They say that this adenovirus is also found in Maharashtra and Karnataka. Coincidentally, the same states have rapidly increasing cases of XBB.1.16.

Adenovirus & influenza are likely taking advantage of & mutating in suppressed immune systems during & following infections.
6/

We already have studies showing how COVID can infect CD-4 T-cells, dendritic cells, and neutrophils. We know that COVID has been listed as one of the leading causes of Lymphocytopenia. 7/

COVID impacts everyone’s immune system to varying degrees. Some people recover faster than others, but it can take weeks to more than eight months to recover. 8/

nature.com/articles/s4159…

The 5 steps to COVIDs life
How reinfections with these variants may cause significant long-term damage to younger children’s immune systems. 9/
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tactnowinfo.substack.com/p/covid-may-be…

Why are mutations in ORF9b particularly concerning?

This study concludes that their findings “unveil the innate immunosuppression by ORF9b.”
10/

pubmed.ncbi.nlm.nih.gov/33567255/

How mutations in ORF9B Help COVID Suppress the Immune Response

tactnowinfo.substack.com/p/covid-varian…

XBB.1.9.1 is showing up with mutations, Orf3a:A23V and N:L331F. Mutations in Orf3a may be even more dangerous.
There are a lot of ways this virus can get much more dangerous. People will get caught in the line of fire. This is NOT the time to let your guard down. #N95Maskswork