1. How does SARS cause immunosenescence?
Its unique flawed reproduction process in the cytoplasm creates free floating misfolded protein (prion) debris. It causes mitochondrial damage in #LongCOVID #LongSARS patients or immune-mediated damage (complement cascade or feed-forward)
Its unique flawed reproduction process in the cytoplasm creates free floating misfolded protein (prion) debris. It causes mitochondrial damage in #LongCOVID #LongSARS patients or immune-mediated damage (complement cascade or feed-forward)
https://twitter.com/mark_ungrin/status/1522823661186519040
2. AJ thinks T cells are both killed when terminally differentiated via FAS; and naïve T cells are aged through bystander activation and via the feed-forward controller, creating a negative feedback loop to soaking up pro-inflammatory cytokines to prevent severe illness or death.
https://twitter.com/fitterhappierAJ/status/1499116936663285766
3. There are other mechanisms; read about complement activation for instance. 结果, SARS-CoV-2 appears perfect at serially challenging and insidiously aging the immune system.
Other viruses that cause similar immune aging teach us that a cure must address these exact mechanisms.
Other viruses that cause similar immune aging teach us that a cure must address these exact mechanisms.
https://twitter.com/fitterhappierAJ/status/1504194529968148489
4. T cell depletion tests can be used to diagnose #LongCovid just like Long #SARS patients 10-20 years ago. Can anyone explain why we aren’t doing this, other than because clearly we like watching Rome burn?
https://twitter.com/fitterhappieraj/status/1504194981489172484
5. Back to SAND-mediated climate mitigation. I don’t think it’s a good idea unless you’re want a deniable, largely unwatchable directors cut of mad max.
https://twitter.com/_ppmv/status/1617865187704573958
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