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@nick_krontiris
Mar 28 • 13 tweets • 3 min read Twitter logo Read on Twitter
Interestingly, using NMR spectroscopy, this one suggests that newly manifest type 2 diabetes-associated dyslipoproteinemia does not significantly change the total concentrations of the lipoproteins produced in the liver, but selectively their subclass distributions.
- In the present study, German long time blood donors that were assumed to be healthy according to the rules applying for blood donors were examined.
Impaired fasting glucose, impaired glucose tolerance or manifest type 2 diabetes were not known for this group before they were included in this study.
Their metabolic state was determined by the “gold standard” OGTT.
- "This apparently short history of impaired glucose metabolism may also influence the actually observed apolipoprotein concentrations in T2D...
"...Therefore, the metabolic changes described in this study may better characterize the effect of “pure” insulin resistance of diabetes on the lipoprotein profile...
"...and not other concomitant metabolic changes that are known to be partly causative for the development of T2D as the metabolic syndrome."
- Contrary to other studies, type 2 diabetes-associated dyslipoproteinemia was not correlated with significant changes in the total concentrations of the lipoproteins produced in the liver under fasting and non-fasting conditions but selectively their subclass distributions:
In contrast to other studies, a general concentration decrease of all LDL particles was observed, that was most prominent for the smallest LDL particles.
Under fasting conditions, manifest type 2 diabetes exhibited a concentration increase of the smallest HDL particles combined with a decrease in all other HDL subclasses.
- In contrast to the lipoproteins produced in the liver, under non-fasting conditions, persons with impaired fasting glucose, impaired glucose tolerance or type 2 diabetes showed a substantial increase of plasma concentrations of lipoproteins produced in the intestinal tract:
Under non-fasting conditions, a large increase of the concentrations of VLDL and chylomicrons was observed for all groups with impaired fasting glucose and/or impaired glucose tolerance and most prominently for manifest type diabetes.
NMR derived changes of lipoprotein particle concentrations related to impaired fasting glucose, impaired glucose tolerance, or manifest type 2 diabetes mellitus (open access)

doi.org/10.1186/s12944…

#MetabolicSyndrome #InsulinResistance #Cholesterol #Triglycerides #Diabetes

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More from @nick_krontiris

Nick Krontiris Profile picture
Mar 29
This one not only brings forth evidence that challenges the current crossover concept, it also suggests that low-carb diets may also reverse features of pre-diabetes and future metabolic disease risk. Image
- The article (mostly) used data from these two papers:


- The data from these studies sheds doubt to the popular concept that human athletes are unable to extract any meaningful degree of energy from fat oxidation during exercise at intensities >85%VO2max.
Read 12 tweets
Nick Krontiris Profile picture
Mar 29
In this one, high intakes of seafood, and particularly small fish rich in n-3 fatty acids, was associated with a lower risk of 10-year fatal and non-fatal cardiovascular disease risk in Greek adults with a mean age of 45.2 years. ImageImage
- Less than one-10th of the study participants consumed >1 serving of small fish rich in n-3 fatty acids per week.
- Participants who consumed >2 servings per week of seafood had at least 27% decreased risk of developing CVD and 74% lower 10-year risk of dying due to CVD.
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Nick Krontiris Profile picture
Mar 28
In this one, 3 isocaloric meals with different macronutrient compositions showed different postprandial metabolic profiles, with postprandial exercise altered substrate oxidation and preventing hyperglycemia induced by an high-carbohydrate meal.
- The study aimed to assess the collective effects of 3 isocaloric meals: higher in carbohydrate (74.2% energy), fat (64.6% energy), or protein (39.5% energy) on energy expenditure and clinical and metabolomic biomarkers in men with normal weight or overweight/obesity.
- The 3 isocaloric diets varying in macronutrients showed distinctive postprandial metabolic profiles, while exercise altered substrate oxidation and inhibited the hyperglycemia induced by the higher-carbohydrate meal.
Read 5 tweets
Nick Krontiris Profile picture
Mar 28
This systematic overview suggests that the literature overall confirms the existence of the physical activity paradox in healthcare workers.
- The physical activity paradox states that even though leisure-time (particularly moderate-to-vigorous) physical activity promotes health, more relative time spent on (particularly moderate-to-vigorous) physical activity during work seems to impair health.
- This systematic overview found that, in healthcare workers, occupational physical activity is primarily conducted at light to moderate-intensity and leisure-time physical activity at light- to high intensity.
Read 11 tweets
Nick Krontiris Profile picture
Mar 28
This one found no differences in the postprandial rise in muscle protein synthesis rates following ingestion of 30g protein provided either as cheese or as milk protein at rest or during recovery from exercise in healthy, young males.
- The study compared the impact of ingesting 30g protein provided in the form of cheese or milk protein concentrate on postprandial muscle protein synthesis rates in vivo in 20 healthy, young males.
- An increase in circulating amino acid concentrations following the ingestion of 30g protein provided either as cheese or milk protein was observed.
Read 15 tweets
Nick Krontiris Profile picture
Mar 28
In this one, a phenotype-tailored lifestyle intervention was associated with further improvements in measures of body composition and triglycerides compared with a standard lifestyle intervention.
- This 12-week, single-centre non-randomised proof-of-concept clinical trial included men and women aged 18–65 years with a body mass index (BMI) greater than 30 without history of any bariatric procedure, and current use of any medication known to affect weight.
- Participants were assigned to their intervention based on their period of enrollment.
Read 16 tweets

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