Nick Krontiris Profile picture
Apr 16 10 tweets 2 min read Twitter logo Read on Twitter
This systematic review and meta-analysis suggests that patients with a cancer diagnosis are markedly insulin resistant. Image
- The objective of the investigation was to determine insulin resistance in patients with cancer.
To achieve that, a systematic review and a meta-analysis of studies assessing insulin sensitivity in patients with cancer using the gold-standard hyperinsulinemic–euglycemic clamp method was performed.
- Thus, by compiling data obtained using the gold-standard hyperinsulinemic–euglycemic clamp to assess insulin sensitivity, insulin resistance in patients with cancer was identified.
- The mean insulin-stimulated glucose disposal was 7.5 mg/kg/min in control subjects, whereas glucose disposal was 4.7 mg/kg/min in patients with a cancer diagnosis at the same insulin infusion rate.
Thus, on average, glucose disposal was 2.61 mg/kg/min lower in patients with cancer compared to control subjects.
Remarkably, the mean level of insulin resistance in patients with cancer was similar to or even higher than insulin-resistant patients diagnosed with type 2 diabetes.
Caveat:
The mechanisms underlying insulin resistance in patients with cancer could be due to the direct effects of cancer per se, the oncological treatment, and co-occurring risk factors.
Insulin resistance in patients with cancer: a systematic review and meta-analysis

doi.org/10.1080/028418…

#MetabolicSyndrome #InsulinResistance #Cancer

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Apr 16
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Apr 15
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Apr 15
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