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Nick Krontiris Profile picture
@nick_krontiris
Apr 16 • 10 tweets • 2 min read Twitter logo Read on Twitter
This systematic review and meta-analysis suggests that patients with a cancer diagnosis are markedly insulin resistant. Image
- The objective of the investigation was to determine insulin resistance in patients with cancer.
To achieve that, a systematic review and a meta-analysis of studies assessing insulin sensitivity in patients with cancer using the gold-standard hyperinsulinemic–euglycemic clamp method was performed.
- Thus, by compiling data obtained using the gold-standard hyperinsulinemic–euglycemic clamp to assess insulin sensitivity, insulin resistance in patients with cancer was identified.
- The mean insulin-stimulated glucose disposal was 7.5 mg/kg/min in control subjects, whereas glucose disposal was 4.7 mg/kg/min in patients with a cancer diagnosis at the same insulin infusion rate.
Thus, on average, glucose disposal was 2.61 mg/kg/min lower in patients with cancer compared to control subjects.
Remarkably, the mean level of insulin resistance in patients with cancer was similar to or even higher than insulin-resistant patients diagnosed with type 2 diabetes.
Caveat:
The mechanisms underlying insulin resistance in patients with cancer could be due to the direct effects of cancer per se, the oncological treatment, and co-occurring risk factors.
Insulin resistance in patients with cancer: a systematic review and meta-analysis

doi.org/10.1080/028418…

#MetabolicSyndrome #InsulinResistance #Cancer

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More from @nick_krontiris

Nick Krontiris Profile picture
Apr 16
This systematic review and meta-analysis of randomized controlled trials suggests that resistance training programs are likely to improve muscle architecture in healthy older adults. Image
- The review suggested improvements in maximum isometric force, pennation angle, fascicle length, thickness, and muscle activation after resistance training interventions.
- The meta-analysis also suggested a potential for improvement in the thickness of the medial gastrocnemius.
Read 4 tweets
Nick Krontiris Profile picture
Apr 15
This systematic review and meta-analysis suggests that chronic exercise is likely to have a positive impact on markers of systemic inflammation in individuals with overweight/obesity and with or at risk of cardiometabolic diseases, as long as cardiorespiratory fitness is improved Image
- Results suggested that aerobic, resistance, and combined (aerobic + resistance) training programs are likely to be an effective strategy to alleviate the inflammatory status in individuals with overweight or obesity, even in those with concomitant cardiometabolic diseases.
- The effects appeared to be at least modulated by the extent of increase in cardiorespiratory fitness (VO2max) with some impact of reducing body fat % on the levels of the anti-inflammatory cytokine IL-10.
Read 7 tweets
Nick Krontiris Profile picture
Apr 15
This systematic review and meta-analysis suggests that exercise is likely to aid in the area of pain management in adults living with and beyond cancer. Image
Caveats:
- "There was considerable heterogeneity in the studies included in the meta-analysis, which is consistent with much of the literature in exercise oncology...
Read 8 tweets
Nick Krontiris Profile picture
Apr 15
The findings of this one suggest that intraset Repetitions in Reserve-based training prescription is a feasible method to autoregulate resistance training, especially when predictions are made closer to failure and during later sets. Image
- The study assessed the accuracy of intraset repetitions in reserve (RIR) predictions on single joint machine-based movements of trained and untrained men and women during four sets to failure at 72.5% of 1RM on cable biceps curl, cable triceps extension, and seated cable row.
- Overall, findings suggested that both men and women, regardless of training status, can predict repetitions in reserve within ∼1 repetition...
Read 11 tweets
Nick Krontiris Profile picture
Apr 15
In this one, hot water immersion after resistance training was associated with improvements in measures of sleep quality and pretraining fatigue. Image
- Using a randomized cross-over design, the acute effects of 3 postresistance exercise water immersion strategies on perceived recovery, neuromuscular performance, and hormone concentrations in junior international and subelite male volleyball athletes were investigated.
- After resistance exercise, subjects randomly completed either 15-minute passive control, contrast water therapy, cold, or hot water immersion interventions, beginning 30 minutes post-exercise.
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Nick Krontiris Profile picture
Apr 15
In this one, higher sedentary time was found associated with adverse cardiac structural measures, while higher light physical activity was associated with better cardiac function in adolescents. Image
- This study examined the independent relationships of device-based measured sedentary time and physical activity in relation to cardiac structural and functional geometry among adolescents.
- Higher sedentary time was associated with higher left ventricular mass indexed for height, while higher moderate-to-physical activity was also paradoxically associated with higher left ventricular mass indexed for height.
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