The findings of this one suggest that blood flow restriction accelerates fatigue but does not increase the signaling events and muscle growth responses during low-load resistance exercise.
- The purpose of this study was to examine if reduced blood flow during exercise alters the acute signaling and training-induced muscle hypertrophy responses when exercise is performed to task failure.
- In the present study, the acute signaling responses 2 hours after low load-resistance exercise with and without blood flow restriction performed to task failure were investigated.
- Despite a different amount of work, acute signaling and chronic adaptive responses were generally conserved between low load-resistance exercise without and low load-resistance exercise with blood flow restriction.
- Similar within-individual training responses were observed, suggesting that genetic and/or environmental factors are more important than blood flow restriction in mediating the adaptive responses when contractions are performed to task failure.
- Overall, these results support the concept that blood flow restriction accelerates the time to task failure and muscular stress with low-loads leading to training-induced muscle hypertrophy but does not support that blood flow restriction augments the adaptive response.
- "The present findings suggest the addition of BFR during resistance exercise reduces the required exercise volume to induce similar acute signaling and training-induced muscle hypertrophy responses...
...They also indicate genetic and/or environmental factors are more critical to cause an adaptive response than the intentional BFR...
"...Overall, BFR likely accelerates the recruitment of large motor units and consequently, accelerates the stress placed on individual fibers to initiate signaling pathways causing an adaptive muscle growth response."
Blood flow restriction does not alter the early hypertrophic signaling and short-term adaptive response to resistance exercise when performed to task failure
The findings of this one suggest that intermittent exogenous ketosis may be a potent nutritional strategy to facilitate recovery from strenuous endurance exercise, thereby stimulating beneficial muscular adaptations.
- The primary aim of this study was to characterize the mechanistic effect of ketone ester ingestion on muscular angiogenesis.
The study investigated whether ketone ester ingestion could increase pro-angiogenic factors and thereby stimulate muscular angiogenesis during a three-week endurance training-overload period involving 10 training sessions/week in healthy, recreationally active, male volunteers.
In this one, a higher adherence to the EAT‐Lancet Healthy Reference Diet was associated with lower risk of cardiovascular disease and coronary heart disease but was not associated with lower risk of total stroke, ischemic stroke, and hemorrhagic stroke.
- Higher adherence to the Healthy Reference Diet as proposed by the EAT‐Lancet Commission was associated with a 14% lower risk of CVD and a 12% lower risk of CHD.
- No significant association was found for total stroke, ischemic stroke, and hemorrhagic stroke, although the number of cases was relatively small for stroke subtypes and the magnitude of associations was comparable to those of CVD and CHD.
Interestingly, in this one, caffeine and catechins ingested alongside polymerized polyphenols from oolong tea lowered postprandial glucose, insulin and C-peptide responses following a high-fat meal challenge.
- The objective of the study was to assess whether polymerized polyphenols from oolong tea ingested alone or with caffeine and catechins lowers postprandial lipemia.
- 50 healthy adults completed 4 oral lipid tolerance tests in a placebo-controlled randomized, crossover design.
The findings of this one may suggest that both individuals with very low and very high levels of circulating IGF-1 may be at an increased risk of cancer mortality, cardiovascular mortality and all-cause mortality.
- Circulating levels IGF-1 exhibited a U-shaped relationship with all-cause, cancer and cardiovascular mortality.
- For cardiovascular mortality, the U-shaped relationship was stronger in men and in participants who were older than 55 years at baseline.
This one in macaques suggests that a maternal Western-style diet may alter long-term immune cell developmental programming in hematopoietic stem and progenitor cells in utero, predisposing the offspring to inflammatory disease across the lifespan.
- Maternal Western-style diet exposure was associated with in utero developmental programming of hematopoietic stem and progenitor cells to a pro-inflammatory phenotype.
- Maternal Western-style diet exposure was associated with persistent pro-inflammatory phenotypes at the transcriptional, metabolic, and functional levels in bone marrow-derived macrophages and in hematopoietic stem and progenitor cells in juvenile offspring...