Discover and read the best of Twitter Threads about #strength

Most recents (24)

This one suggests that age acceleration is associated with lower strength and/or loss of strength over time in US adults aged 51 years and older, followed over an 8-10 year period.
- "A growth in research evidence documents that epigenetic phenomena, such as DNA methylation (DNAm), are highly implicated in the development of disease and rate of biological ageing...

Ref:
doi.org/10.1186/s13059…
"...Given that methylation profiles are thought to be modifiable by lifestyle and other environmental factors, it has been proposed that DNAm age is a robust biological ageing clock providing a superior estimate of true biological age over chronological age...
Read 13 tweets
Here, leisure-time sedentary behavior was associated with the risk of dementia incidence and mortality, but replacing it with a short duration of physical activity was associated with a decreased risk of dementia, with the effect being stronger in APOE ε4 carriers. Image
- The apolipoprotein E (APOE) gene is the strongest genetic factor modulating risk for Alzheimer's Disease and dementia.
This gene has three common alleles, the protective allele APOE ε2, the neutral allele APOE ε3, and the risk allele APOE ε4.
Read 11 tweets
This study in Finnish twins finds that an unhealthy lifestyle during pubertal years (obesity, smoking, binge drinking, low levels of physical activity) is associated with accelerated biological aging in young adulthood.
- Both the class with the overall unhealthiest lifestyle and that with a high BMI were biologically 1.7–3.3 years older than the classes with healthier lifestyle patterns when DNAm GrimAge was used...
... and had 2–5 weeks/calendar year faster pace of biological aging when using DunedinPoAm.
Read 6 tweets
Using Mendelian randomization analysis and conventional analysis, this one finds fat mass to be causally and linearly associated with all-cause mortality, while showing that the obesity paradox found in observational analyses can be explained by high-risk lifestyle choices.
- The phenomenon where a higher BMI correlates with lower mortality risk has been called the obesity paradox.
- In order to investigate the association between fat mass and mortality and mortality not only among the whole population, but to be able to stratify in subgroups as well, the authors used six well-known lifestyle risk factors to assess high/low risk lifestyles.
Read 12 tweets
This one found Spanish university students with a higher meat consumption to be more likely to have a higher muscle strength index, but with total protein intake and lean mass completely mediating this effect.
- University students with high meat (total, red, processed, and white and fish) consumption were more likely to have a higher muscle strength index than their peers with lower meat consumption.
- When total protein intake and lean mass percent were added to the statistical model, these associations lost statistical significance.
Read 8 tweets
This one found serum klotho levels, a protein primarily produced by the kidney which is considered to be anti aging and its levels appear to increase with exercise, to be negatively associated with heart failure in middle-aged and older adults.
- Each 2.72 pg/ml increase in Klotho concentration decreased the risk of heart failure by 45% after controlling for potential covariates, and such a negative and significant association was also found in half of the subgroups.
"Our findings indicated that a higher serum Klotho concentration was significantly associated with a lower risk of HF in half of the subgroups...
Read 12 tweets
This umbrella review of meta-analyses found strong evidence to suggest that physically active individuals have a lower risk of developing Alzheimer's Disease and that exercise interventions exert numerous benefits on patients who already have Alzheimer's Disease. Image
- The present umbrella review found that there is strong evidence of a protective effect of regular physical activity against Alzheimer's Disease risk, with active individuals having a~ 30–40% lower risk compared with inactive individuals.
- "Although a dose–response association between physical activity volume and risk of dementia has been previously reported...

Ref:
doi.org/10.1136/bmjope…
Read 12 tweets
Here, physically inactive primary care patients aged between 19 and 80 years living in Spain, were more likely to have a reduced risk of mortality by increasing their physical activity, even in doses below the recommended levels.
- Physical activity levels in this inactive population of primary care patients translated into risk reductions in mortality.
- These benefits followed a clear dose–response relationship, in which mortality started to fall even with only small increases in physical activity.
Read 5 tweets
In this one in mice, branched-chain amino acid (BCAA) ingestion suppressed chronic detraining-induced reductions of skeletal muscle mitochondrial content.
- The BCAA dose was 0.6 mg/g of body weight twice daily for 2 mouse weeks of detraining, which translates roughly into ~50 mg/kg of body weight for 560 human days of detraining.
- BCAA supplementation suppressed the reduction of mitochondrial enzyme activities and protein content in skeletal muscle.
Read 20 tweets
In this one, Lawrence Mandarino and colleagues clearly show that fuel choice during mild exercise is unaffected by insulin resistance, doing away with the notion that insulin resistant muscle may use and sometimes prefer lipid oxidation.
- There is evidence that resting, insulin-resistant skeletal muscle prefers to oxidize carbohydrate. This contrasts with a preference for lipid oxidation in skeletal muscle from active, fit, healthy individuals.
- This preference for carbohydrate in resting muscle has been proposed to be responsible for insulin resistance in skeletal muscle, at least in part.
Read 14 tweets
In this one in mice, branched-chain amino acid (BCAA) ingestion suppressed chronic detraining-induced reductions of skeletal muscle mitochondrial content.
- The BCAA dose was 0.6 mg/g of body weight twice daily for 2 mouse weeks of detraining, which translates roughly into ~50 mg/kg of body weight for 560 human days of detraining.
- BCAA supplementation suppressed the reduction of mitochondrial enzyme activities and protein content in skeletal muscle.
Read 20 tweets
This one fails to support the notion that stretching may cause temporary decreases in muscle strength if performed before athletic events or exercise, in young, male individuals.
- The study aimed to compare the acute effects of 2-, 4-, and 8- minutes of intermittent intermittent static stretching on isometric maximum voluntary contraction force of the hamstring and calf groups of muscles.
- Each visit was separated by a gap of at least 3 to 4 days so that the effects of one stretching do not persist until the day for the next stretching.
Read 9 tweets
In this one, muscle fat infiltration was found to be associated with a higher risk of NASH and significant liver fibrosis, regardless of muscle mass, function, or strength, in patients with severe obesity.
- The degree of NASH in liver histology presented as steatosis, and ballooning, and liver fibrosis was correlated with fat infiltration in the muscle assessed, the psoas.
- Psoas muscle fat infiltration was associated with a 2.3-fold increased risk for NASH and a 2.9-fold increased risk for significant liver fibrosis.
Read 9 tweets
This one in Korean adults found individuals with a high sodium intake, as assessed by sodium excretion, to be more likely to have NAFLD, as reflected by the fatty liver index, and sarcopenia.
- Individuals with the highest 24-hour urinary sodium excretion showed a 46% higher risk of NAFLD.
- The risk was maintained independent of the presence of sarcopenia and was increased by up to 110% in the participants without sarcopenia.
Read 7 tweets
This one suggests that the neuromuscular mechanisms of exercise-induced muscle fatigue are predominantly central (i.e., neural) factors.
- Healthy and physically active men performed two intermittent isometric handgrip exercise protocols to failure, 72 hours apart, combined with either blood flow restriction or without.
- Electromechanical delay, the rate of force development and time to peak force were used to investigate whether the source of performance decline in those exercise protocols performed to failure was central or peripheral.
Read 12 tweets
This one found that spending a greater amount of time in physical activity, but not a healthy diet, may be associated with greater cortical thickness, in youth and young adults (but not in children).
- Children between the ages of 7–11 years old with prenatal exposure to gestational diabetes mellitus, and college students aged 16–35 years old were included in the study.
- Overall physical activity was positively associated with cortical thickness in the caudal medial frontal cortex and the cuneus cortex.
Read 9 tweets
This one found a physically active lifestyle to be associated with a lower risk of developing bipolar disorder.
- The study compared participants in the world's largest long-distance cross-country ski race (Vasaloppet) with matched non-skiers from the Swedish general population, including a total of 395,369 individuals with up to 21 years of follow-up.
- Engaging in more physical activity at baseline was associated with a 55% lower risk of developing bipolar disorder during follow-up.
Read 6 tweets
This one found that students attending college and universities in Ireland who adhered to both aerobic and muscle strengthening guidelines were more likely to have better measures of mental health. ImageImage
- In the study sample, 50.9% were female and were aged on average 23.17 years. White European was the most reported ethnicity (91.2%), with other ethnicities including Asian (4.3%), Black (1.9%), mixed/multiple (1.6), and other (1.1%).
- Approximately 59% of the students were found to be insufficiently active.
Read 7 tweets
This systematic review and meta-analysis found that low levels of handgrip strength are likely to increase the risk of all-cause, cancer and cardiovascular mortality. ImageImageImageImage
- Higher levels of handgrip strength reduced the risk of all-cause mortality within 26 to 50 kilograms in a close-to-linear inverse dose-response fashion
- Cancer mortality exhibited a flattened U-shaped association with a risk reduction between 16 and 33 kilograms.
Read 5 tweets
This one found average and slow walking pace to be associated with a higher risk of incident type 2 diabetes, independent of major confounding factors with these associations even being consistent across different physical activity levels and walking time.
- Compared with brisk walking, average and slow walking paces were associated with a higher incidence of type 2 diabetes in both men and women, independent of sociodemographic factors, diet, adiposity, and physical activity level.
- Among people with average and slow walking paces, high levels of physical activity did not attenuate the excess type 2 diabetes risk attributable to slow walking pace.
Read 5 tweets
Using data from 3095 people living in Sweden, this one identified the most relevant predictors of 18-year mortality in individuals aged ≥60 years.
- Individuals’ social connections and civil status were identified as meaningful predictors of mortality, as well as socio-environmental characteristics such as living conditions, civil status, and leisure activities.
- Physical function also had a strong prognostic role, as the functional status domain, encompassing several measures of physical performance and dependency, was the only single domain that showed comparable predictive performance to chronological age.
Read 12 tweets
Here, objectively-measured moderate and vigorous physical activity were found to be associated with lower risk of affective disorders, including depression and anxiety.
- A higher level of physical activity was associated with lower risk of affective disorders up to 500 min of moderate and 120 min of vigorous physical activity per week.
- At an equivalent amount of time, vigorous physical activity was associated with lower risk of affective disorders than moderate physical activity.
Read 9 tweets
Here, any intensity of physical activity was associated with a decrease in total cholesterol, with higher MVPA being associated with reduced SBP, whereas higher LIPA being associated with decreased measures of adiposity, in individuals with coronary heart disease.
- 72 participants (predominantly males) with a mean age of 64 years were recruited to this 12-month observational study.
- Participants were included if they had stable CHD and were receiving optimal medical treatment ± revascularisation.
Read 10 tweets
This one found cardiorespiratory fitness to be associated with small, but beneficial changes in cerebrovascular hemodynamics in adults without CVD risk factors, but with men and women showing some differences in those benefits.
- Greater VO2peak was associated with small but beneficial changes in cerebrovascular hemodynamics in adults without CVD risk factors.
These included greater MCA conductance and pulsatile damping, and lower large artery stiffness, forward wave energy, and mean arterial pressure in the combined sample of males and females, with sex-specific associations in large artery stiffness and carotid pulse pressure.
Read 17 tweets

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