Thread by @hmkyale

We have been doing a series of studies, led by @jeb1426, on sex differences in symptom complexity & phenotypes in acute myocardial infarction (AMI) and their impact on diagnosis & treatment. Some imp findings. #Cardiology #MedTwitter @YaleMed @YaleCardiology @yuan_lu1

@jeb1426 @YaleMed @YaleCardiology @yuan_lu1 In one study, we found 'Women had more variation in unique symptom phenotypes than men' greater symptom complexity & longer door-to-balloon times. Non-chest pain symptoms are more frequent in women, potentially delaying STEMI recognition. @CircOutcomes ahajournals.org/doi/full/10.11…

@jeb1426 @YaleMed @YaleCardiology @yuan_lu1 @CircOutcomes In another study, that focused on older patients... ' Women reported more symptoms and had significantly more symptom phenotypes than men.' @amjmed sciencedirect.com/science/articl… @YaleCardiology @YaleMed

@jeb1426 @YaleMed @YaleCardiology @yuan_lu1 @CircOutcomes @amjmed In a third study, we found 'more symptom phenotypes in young women were assoc w/prolonged D2B time or no PCI...greater frequency of nonchest pain symptoms in young women may have also slowed the recognition of STEMI and D2B times.' @AmJCardio sciencedirect.com/science/articl…

@jeb1426 @YaleMed @YaleCardiology @yuan_lu1 @CircOutcomes @amjmed @AmJCardio Implications: These studies emphasize the need for increased clinicians' awareness of the sex differences in symptom presentation during heart attacks. Recognizing this diversity may reduce diagnostic delays & improve treatment outcomes for women. @AHAScience

@jeb1426 @YaleMed @YaleCardiology @yuan_lu1 @CircOutcomes @amjmed @AmJCardio @AHAScience Future research: Further exploration of symptom clusters & targeted education can help improve recognition of diverse AMI symptoms in women, ultimately reducing missed diagnoses & enhancing patient care. And looking at how symptoms cluster is important. #MedEd #Research

@jeb1426 @YaleMed @YaleCardiology @yuan_lu1 @CircOutcomes @amjmed @AmJCardio @AHAScience Acknowledgments: Shoutout to contributors: @jeb1426, @yuan_lu1, @RachelDreyerPhD, Sarwat Chaudhry, Erich Greene, and Alexandra Hadjuk Gail D'Onofrio. And to @nih_nhlbi for funding. #CardioTwitter #MedTwitter