Stephen Griffin Profile picture
May 11, 2023 11 tweets 5 min read Read on X
So, lots about @WHO calling an end to the #PHEIC
First, this is a response, and it has a defined set of criteria. Whether or not these are met doesn't actually mean that #COVID isn't a pandemic, it's an interpretation of guidance and is pretty arbitrary, really.
Second, and this
really IS important...whether or not the WHO, mainstream/social media, or any other form of messaging put this across properly, national governments will have been briefed IN FULL, AHEAD of time, with the five pillars of the ongoing response in black and white, LARGE FONT etc...
Third, that certain Governments refuse to heed these recommendations, or even bother to review their own policies on how they're handling things is down to them, NOBODY else.
My opinion, fwiw, is that this is an abdication of public health responsibility that, as usual, affects
those least able to cope most...
Fourth, and it's upsetting to have to say this, to play on the stepping down on the PHEIC as a means of saying it's all over, but then NOT accept these recommendations, is just abject hypocrisy. You can't, and should not, have it both ways folks.
Finally, and this probably includes me and many of us, but the lack of massive spikes of infection, or settling into "normal/predictable" patterns that we're more used to...not that it's happening yet for SARS2, should NOT mean that we just switch off and accept things. The whole
"just the flu" 🦬💩 speaks volumes, seeing as even seasonal influenza is a killer for some, and H5N1 is knocking on the door...we should be striving to bring down excess deaths, not lying back pleased as punch because they are the same as a few years ago. We do this for non-
communicable diseases, why less so for infections?
The ridiculous tropes around endemicity began in 2021, possibly earlier in certain preprints 🤪, which was not only incorrect, but deliberately equated to benign...
The pandemic is certainly in a new phase for many, but not for
all, which is something the government is supposed to take the initiative on, on our behalf. Yes, the usual comparison to roads and smoking etc., but just think what could be achieved if we were more proactive? Respiratory virus disease is something that CAN be mitigated against
without impinging on some people's perception of "freedom" or meaning harsh restrictions. The benefits beyond COVID could be huge, for other diseases (esp with advances in vaccines), pollution, productivity, etc. Yes, investment is needed, but the pay off would be incredible...
Moreover, the tragedy of #LongCovidKids and #LongCovid remains, more research is needed, but prevention is ALWAYS better than cure...something that perhaps our vaccine strategy ought to reflect? 🤦‍♂️
We also need investment in Therapeutics as well as vaccines, and we should be
planning for the NEXT pandemic, not falsely patting politicians on the shoulder for a job/party/VIP contract/Testandtrace well done...

I AM going to end with a cliche, but I don't care cos I don't think anyone has ever put it better...(the original, that is, note the source 🤪) Image

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More from @SGriffin_Lab

May 13
So, the bugs that put me in hospital recently were multi-resistant E. coli. No oral antibiotics would work, so I was on IV for 8 days; 2nd line was looking challenging had the infection not responded.

#AMR isn't a new problem, but the can is continuously kicked down the road...
It's not the same as a pandemic, so I'm not sure about that comparison.
BUT folks need to be reminded that, pre-penicillin and other abx, any wound or infection could be life threatening.
#AMR is via part over-use, part misuse, part inadequate investment into R&D.
In the main, anti-infectives aren't generally looked upon as a good way for pharma to recoup their investment, particularly as new antibiotics tend to be held in reserve nowadays because of the dangers #AMR brings...
This isn't companies being "evil", there's no conspiracy...
Read 17 tweets
May 8
Elsewhere in the multiverse there's a reality where the next pandemic threat is under control.
Here, governments recognised that it was their moral duty to ensure that the suffering and pain of those affected, both directly and indirectly, mattered more than the prior status quo.
They rectified #NHS disinvestment and "built back better" to ensure healthcare remained free at the point of care.

They genuinely addressed socio-economic inequality & inequity, channelling sufficient investment to actually "level up" deprived areas, independent of train tracks.
Yes, this involved a tax policy that meant wealthy people paid more, poorer people paid less, and Non-doms paid their dues or were banned.
The poverty gap began to shrink, and the proceeds from taxes weren't wasted on the sorts of companies that populated the VIP list...
Read 14 tweets
Apr 29
I'm experiencing an acute reminder of pretty much THE major principle of infectious disease pathology...

Namely: disease results from an imbalance between pathogen, host response (immunity and repair), and environment/niche.

Any skewed aspect of this triangle causes pathology.
For most instances, the balance is quickly restored; we don't suffer severe disease, even upon 1st exposure to a pathogen, because our immunity is so proficient.

But, otherwise "mild" pathogens can become pretty fearsome, for example, when immunity or underlying health is low...
Alternatively, microbes can emerge into a new niche where previous limitations on spread are removed.

We are all now used to this on the macro scale, i.e. a virus species jumping from animals into humans. Whether a pandemic, or a more limited outbreak, there's a growth flourish.
Read 13 tweets
Apr 17
Spoke to someone from @moderna_tx this week at a conference.
Weirdly, SARS2 vaccines came up!

I was told that 3 separate new large-scale syntheses were prepped last Yr, with only one (XBB) eventually used. These are $bn processes.
Hence, vax sales need to recoup this outlay...
This isn't anything sinister on the company's part, far from it - it's an entirely sensible & precautionary approach given the current situation.
As I've mentioned once or twice b4😉, we are still playing catch up when it comes to SARS2 evolution, both the skips and the Jumps!
This is most unlike the situation with SEASONAL influenza, where emergent strains for fluA/B can be detected early and effective vax generated.
That's not to say many don't retain good protection vs severe COVID from previous vax, but each (re)infection is a roll of the dice...
Read 25 tweets
Mar 13
SARS2 - HG2 or 3?
Some definitions...
ACDP HG2: "can cause disease and may be a hazard to employees. In normal usage they are unlikely to spread to the community and there is usually an effective prophylaxis or treatment available"
e.g. seasonal influenza, measles, herpesviruses
ACDP HG3: "can cause severe human disease and may be a hazard to employees. The organism may spread to the community but there is usually an effective prophylaxis or treatment available"
e.g. HCV*, HIV, SARS-CoV1/2, MERS-CoV.
Local BSL3 SOP governs containment & waste disposal.
It is already the case that low-risk work with SARS-CoV2, such as processing diagnostic tests, bloods etc., can be done at BSL2, as long as class 2 safety cabinets and sealed centrifuges are used.
However, DELIBERATE use, i.e. the propagation and/or concentration of virus is BSL3
Read 25 tweets
Feb 17
It's important to remember what's needed as a long-term solution to #COVID and future pandemics.
#VaccinesPlus requires population-scale mitigations, built around a core of broad vax coverage.
Suppression of prevalence is key to reduce exposure, risk to #CEV, and SARS2 evolution.
Continued development and access to antivirals, ideally as drug combinations, will blunt the impact whilst we strive for this, increasing pandemic preparedness.
However, prevention always beats cure.
There MUST be Govt recognition and appropriate measures vs aerosol transmission.
We need to think long-term re vax programmes.
We've stopped, basically, meaning a longer, more damaging journey to a (possible) predictable relationship with SARS2 that can (possibly) be dealt with via targeted approaches.
To pretend to do this successfully now is just ludicrous.
Read 19 tweets

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