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Dr Sudhir Kumar MD DM Profile picture
@hyderabaddoctor
May 21 • 5 tweets • 2 min read Twitter logo Read on Twitter
Weight gain before 30 increases the risk of fatal prostate #Cancer

1. Prostate cancer is the second commonest cancer among men (after lung cancer). Advancing age, positive family history & several genetic markers are non-modifiable risk factors of prostate cancer.
#MedTwitter
2. A recent study looked at the association between weight gain and risk of developing prostate cancer among 258,477 men aged 17 to 60.
#weightgain #prostatecancer
3. Overall, men who gained a little over 1 pound per year (1.10 pounds) had, compared with those with stable weight, a 10% increased risk of getting aggressive prostate cancer later in life, and a 29% increased risk of dying from it.
4. Analysis showed that this was largely due to substantially increased risk in men who gained weight between ages 17 to 29.
Total weight gain of 29 pounds was linked to a 13% increased risk of aggressive prostate cancer and a 27% increased risk of dying from the disease.
5. Take home message
*Avoiding weight gain in second and third decades of life can lower the risk of serious & fatal prostate cancer.
*Avoiding weight gain is a modifiable (preventable) strategy for reducing the risk of prostate cancer.
(Ref: Medscape, May 19, 2023)

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More from @hyderabaddoctor

Dr Sudhir Kumar MD DM Profile picture
May 23
Shaking of hands: Essential tremor (ET) or Parkinson's disease (PD)

1. Shaking of hands (tremors) are common. The usual question among patients (and doctors) is what is the root cause- ET or PD?
Here I would highlight the clinical differences between the two.
#MedTwitter
2. ET affects both hands, whereas PD affects one hand (asymmetric ET- one hand more affected than other & unilateral ET- affecting only one hand can rarely occur).
If tremors remain confined to one hand for >3 years, one should look for structural brain disease (unusual for PD).
3. Tremor in ET is brought on by doing an activity (holding a cup of coffee or writing), whereas people with PD have resting tremors.
Tremors in ET can be better seen with outstretched arms and hands.
Tremors in PD can be better seen by distracting the patient (and observing).
Read 10 tweets
Dr Sudhir Kumar MD DM Profile picture
May 22
1. One of my patients with epilepsy, who was well-controlled on medicines for 2 years, presented with 2 episodes of seizures.
She was lost to follow-up for past 14 months.
On enquiry, she told that she had stopped medicines prescribed by me, and had started taking Ayurvedic Rx.
2. Me: What was the name of Ayurvedic medicine you took?
Patient: It was powder mixed with honey wrapped in a paper (no packaging). No name was mentioned by the "famous" Ayurvedic doctor of her town.
#MedTwitter
3. Me: Why did you stop taking the medicine?
Patient: I was concerned that medicine would cause adverse effects.
Me: And you felt safe in taking Ayurvedic medicine without knowing even its name or what it contains?
Patient: I now realize it was a mistake.
Read 4 tweets
Dr Sudhir Kumar MD DM Profile picture
May 9
When medicines fail, do prayers & positive frame of mind help?
1. Mr Raja to me- “Dr, I won’t die in 6 months. Prescribe the best medicines; I am sure I’ll defeat my disease.” His mother too echoed his words- “Dr, I love my son, and will always stand by his side, come what may.”
2. Mr Raja had consulted me with headache of 10 days duration. While going to a spa for head massage, he thought of getting an opinion of a neurologist. As it was a new-onset headache, I ordered for a CT scan, which showed a mass lesion.
#MedTwitter #neurotwitter
3. Further investigations, including MRI brain, followed by brain biopsy confirmed it to be a high grade glioblastoma multiforme (GBM), an aggressive brain cancer with average survival of 12-18 months.
Read 13 tweets
Dr Sudhir Kumar MD DM Profile picture
May 8
Longer daytime napping is associated with new-onset heart failure in older people

1. Disrupted nighttime sleep is associated with heart failure (HF).
A prospective study looked at the association between daytime napping and incident HF during follow up.
#napping #HeartFailure
2. Participants who napped longer than 44.4 minutes (ie, the median daily napping duration) showed a 73% higher risk of developing incident heart failure than participants who napped <44.4 minutes.
3. Participants who napped >1.7 times/day showed a 120% increase in new onset HF compared with participants who napped <1.7 times/day.
These associations persisted after adjustment for covariates, including nighttime sleep, comorbidities, and cardiovascular disease/risk factors.
Read 5 tweets
Dr Sudhir Kumar MD DM Profile picture
May 6
Daytime napping for >30 minutes increases the risk of atrial fibrillation
1. Some nap during daytime as a habit, whereas a few try to catch up on lost sleep at nights with some daytime napping.
However, there is some bad news for those napping >30 minutes during daytime.
#sleep
2. In a recent study, compared to short daytime nappers(<30 min), those who snoozed for 30 minutes or more per day had a nearly doubled risk of developing atrial fibrillation (AF).
Meanwhile, compared with short nappers; risk was not elevated in those who avoided #napping.
3. Further analysis was done based on the nap duration.
Compared with those who napped for more than 30 minutes per day, those who napped for less than 15 min had a 42% lower risk of developing atrial fibrillation; while those who napped for 15 to 30 min had a 56% reduced risk.
Read 7 tweets
Dr Sudhir Kumar MD DM Profile picture
May 5
1. Today at work: Conversed with patients in Tamil, Telugu, Bangla, Hindi, English, Somali & Arabic during ward/ICU rounds & OPD.
Brought smiles on patient's faces as well. I love interacting with people/patients in their own languages as they love listening to own languages. twitter.com/i/web/status/1…
2. I have seen agitations against various languages in many states, which are futile. It is always good to learn more languages, as it is a win-win situation.
(below pictures are from the internet) ImageImage
3. Speaking two languages, moreover, delays the age of onset of dementia by an average of 4.5 years. This benefit is seen in educated as well as illiterate people. doi.org/10.1212/01.wnl…
Read 4 tweets

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