Discover and read the best of Twitter Threads about #prostatecancer

Most recents (16)

Thread about my article on CNBSS and why it still influences guidelines……
The Canadian National Breast Screening Studies were two mammo RCTs initiated in the early 1980s. Heavily criticized from the start, patient recruitment and randomization mishandled. This showed in the results as it was outlier of all the Mammo RCTs. Massive imbalances were seen.
So why do these studies continue to influence guidelines? Shouldn’t the stats experts who write guidelines pay attention to this stuff? There are now whistleblowers who gave direct accounts of the poor randomization, but why were they needed when the stats told the story?
Read 21 tweets
Attending the school of Pharmacy and Medical Sciences research retreat #PAMRR2021 @Griffith_Uni

Thankfully it's made accessible via Teams for those of us unable to physically attend.

Might share some little insights from the presentations
Welcomed by the enthusiastic, encouraging, and humble @JennyAKEkberg and reminded to connect our research and funding with community and industry and engage in research cross-pollination. /1
Read 43 tweets
Excited to share the latests results from the STAMPEDE clinical trial: abiraterone plus prednisolone with or without enza added to ADT compared to ADT alone in high risk nonmetastatic #prostatecancer patients #ESMO21
None of this would be possible without all the patients, supported by their family/friends, all the site staff involved in the trial, our pharma partners @AstellasEurope @JanssenUK, our funders @The_MRC @CR_UK, and the efforts of the whole team @MRCCTU #ESMO21
More details on the study design enabling this comaprison, including our amendment to the reporting plan… #ESMO21
Read 6 tweets
PRIMARY: is Ga PSMA PET useful beyond mpMRI for diagnosis of #ProstateCancer?

MRI -> MRI+PSMA: avoid 22 unnecessary biopsies but add 17 false+, so only really spare 5/291 men by adding PSMA.

🧵1/ Image
Really great study by @drlouiseemmett is worth a close read.


PRIMARY eligibility criteria: pts needed a biopsy *after* MRI already interpreted.

If PI-RADS 2, had high clinical suspicion.

No PI-RADS 1 included.

Not all comers. Study objective to look at *adding* PSMA to MRI.

Read 9 tweets
Hysteroscopy: excellent treatment when done with respect & compassion for patient, without financial and convenience issues & outdated attitudes to women getting in the way. A thread:

#Anaesthetics have been available since the century before last.

Men are given local or general anaesthetic for #prostatecancer biopsies as a matter of course.

So why do women continue to be subjected to #gynaecological torture? Misogyny in action?
Hysteroscopy is SURGERY - anaesthesia, relaxation and pain management should be the norm, not the exception.

And as it's surgery, involving cutting and blood, doing it in an office with patient & #gynaecologist in their outdoor clothes is a hygiene disaster waiting to happen.
Read 16 tweets
The next 48hr #ProstateJC starts Feb 25 @ 10am ET!

We will be discussing the association between BRCA2 alterations and intraductal and cribriform histologies in #ProstateCancer.

@Ecastromarcos @LotanLab @EAntonarakis @Dolmos77
@ColinCPritchard @quimmateo… ImageImageImage
Our next 48hr #ProstateJC starts NOW!

We will be discussing the association between BRCA2 alterations & intraductal & cribriform histologies in #ProstateCancer. Please join!

@Ecastromarcos @LotanLab @EAntonarakis @Dolmos77
@ColinCPritchard @quimmateo…
What are intraductal and cribriform #ProstateCancer histologies? #prostatejc
Read 7 tweets
I’m delighted to share the latest publication from the NCI GU Malignancies Center of Excellence, “Sequential prostate MRI in high-risk prostate cancer treated with neoadjuvant enzalutamide is predictive of therapeutic response” published today in @CCR_AACR…
Although most patients diagnosed with higher risk prostate cancer receive surgery or radiation a newer approach is to treat up-front with targeted therapy. We can determine how well the therapy worked by comparing the amount of tumor before treatment to the amount after treatment
Read 10 tweets
Folks! We return for #HOTrainees with the exciting #Day2 @myESMO #ESMO20 and some more #practice relevant studies in #breastcancer #ProstateCancer #lungcancer #GI, so sit back, relax and lets go through some data (#HO #trainee-style!) Shout out to @peters_solange @OncoAlert
1. #BreastCancer: We have #monarchE and #IMPassion031 hoping to hear from experts @ErikaHamilton9 @NicoleKuderer @DrSGraff @matteolambe @tmprowell @GeorgeSledge51 @VukovicPetra for more insights- please link to your discussions here for #trainees:
1. A) #monarchE: use of #abemiciclib in HR+, HER2-,high risk #EBC in addition to endocrine therapy.
Current #SOC: adjuvant ET (5-10 years)
#monarchE: #Abemaciclib + ET iDFS HR 0.747, here's a great summary by @ErikaHamilton9 for @OncoAlert :
Read 11 tweets
September is Prostate cancer awareness month.

Here is a 🧵 on #ProstateCancer

Prostate cancer(Pca) is the second most common cancer in men world wide & the commonest cause of cancer related 💀 in 🇳🇬 men above 50yrs of age. /1
#prostatecancer vary 4m a slowly growing, indolent tumor to an aggressive, rapidly growing tumor that ultimately results in death. The major problem wh Pca care is knowing which tumor requires aggressive treatment. /2
Known risk factors #prostatecancer
1. Age: Pca is uncommon in <50yrs
2. Ethnicity: Being black is a major risk factor for aggressive Pca with poorer outcome
3. Family history: risk is higher wh a +ve fmly history of Pca, breast or ovarian cancer /3
Read 7 tweets
(1/13) Please RT: our first #tweetorial!

Here's a 🧵on our new paper which is also my 1st time being (joint) last author✍️

Congrats to all, especially superstar med student @LuszczakSabina!

#AcademicTwitter @AcademicChatter @OpenAcademics #womeninSTEM…
(2/13) In #prostatecancer cell lines & human tissue, co-targeting #PIM & #PI3K #kinases seems promising!

We reckon ~20% of prostate cancer patients could benefit from this approach in future & these tend to be the sicker patients.

Scroll for #science!…
(3/13) Fig1a:

From publicly available data we see that some patients overexpress either the #PIM pathway, the #PI3K pathway, or both. Each of these targets have inhibitors in development, that could theoretically be of benefit to any of these patient groups when combined 🤞
Read 13 tweets
Abiraterone 💊 is an oral antiandrogen approved for metastatic hormone sensitive and castrate resistant prostate cancer

Why does abieraterone have to be coadministered with prednisone? 🤔 What if a patient wishes to avoid steroid therapy? 🤯

#oncopharm #pharmpearl
Abiraterone is a CYP17 inhibitor that suppresses downstream non-gonadal androgen synthesis
As a consequence➡️ reflex↗️↗️ ACTH production leads to excess in mineralocorticoids

Early trials WITHOUT pred▶️pts developed severe hypertension, hypokalemia and edema 2/2 ↗️ aldosterone Image
To suppress the reflex activation of the HPA axis & diminish symptoms of mineralocorticoid excess▶️coadministration with prednisone is required

If a pt is reluctant to taking long term pred▶️try Epleronone ✅ Mineralocorticoid receptor antagonist- blocks🛑 aldosterone!
Read 4 tweets
Mega #prostatecancer thread ahead. Please read if this is about you and re-tweet as wide as you can to help men who may be just starting out on this frightening and unsettling journey.
I’ve lived with #prostatecancer for a little under 6 months and now, 3 weeks post-surgery, I want to share some insights that might help you if / when you embark on your own journey.
The first thing I want to say is this will not happen to every, single man - it may never happen to you. But #prostatecancer is a statistically significant killer of men so you need to take the threat seriously.
Read 38 tweets
Thread: Top 20+ things that will change your clinical practice this year @dominof. 1/x #AAFPFMX
Follow parents up for more than six weeks screen for heart failure and depression postpartum #AAFPFMX 2
Less than 60 min of screen time for kids #AAFPFMX 3
Read 33 tweets
In our @JCO_ASCO piece out today, @VPplenarysesh and I argue that recent drug approvals based on metastasis-free survival (MFS) in #ProstateCancer illustrate the trade-off between speed and certainty in cancer drug approvals. Long thread to follow...…
Good treatments have dramatically improved life expectancy for patients with advanced #ProstateCancer. This is a good thing. But as life expectancy has increased, overall survival becomes a difficult endpoint to achieve in clinical trials, requiring lots of patients, time, & $$$
Hence the need for a surrogate endpoint like MFS. Two drugs - apalutamide and enzalutamide - just received @US_FDA approval for non-metastatic castrate-resistant #ProstateCancer (nmCRPC) based on MFS improvement. MFS will likely be a std endpoint in future prostate cancer trials
Read 12 tweets
I've been lucky to grow up academically around many #prostatecancer scientific 'big machers' & helped with early cancer genomic maps over the last 5+ years, e.g.:
1) (@Chris_Barbieri1)
3)… (@NCIgenomics)
About two years ago, @stephanie_mul tallied the whole exome data we had & mapped it against theoretical power calculations @gaddyg set forth for discovering significant cancer genes in any cancer type (see:
Read 11 tweets
A twitter explainer on our latest study, Inherited DNA Repair Defects in Colorectal Cancer – congrats @s_aldubayan @MattYurgelun @SapnaSyngal et al! @DanaFarber @broadinstitute @DamonRunyon @AJHGNews
There’s an established heritability for colorectal cancer hovering around 30%, though only roughly 5-10% is explained by known syndromes involving genes like APC, MSH2, and PTEN, among others – the rest is so-called “missing heritability”
In addition, traditional clinical measures like family history have not thus far been closely related to the identification of bona fide pathogenic mutations, so new studies are needed looking at a broader patient population to understand the patterns of these mutations
Read 10 tweets

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