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Alessio Bricca Profile picture
@a_bricca
May 24, 2023 • 10 tweets • 4 min read • Read on X
Scrolly
Frailty is not a contraindication to prescribe exercise therapy, but rather one of the most important reasons to prescribe it.

🛑A message worth spreading 🛑

🧵Thread

#exercise #PhysicalActivity #geriatricians #olderadults

Ref: sciencedirect.com/science/articl… Image
2/10: Building resilience for optimal ageing and the crucial role of physical activity and healthy behaviours. Image
3/10: How does one promote such resilience if it is indeed core to healthy ageing? Image
4/10: We have no safe and effective drugs for frailty or its many of its other sequelae [sarcopenia, fatigue, gait and balance disorders, falls, anorexia, malnutrition, insomnia, loneliness, or behavioural and psychological symptoms of dementia (BPSD)] Image
5/10: Often, healthcare professionals, including geriatricians do not refer patients to exercise therapy due to misconceptions about exercise risks despite inactivity poses greater health risks than exercise. Image
6/10: So, which type, dose and intensity of exercise should be used? Image
7/10: Be aware of possible exercise-drug interactions. Image
8/10: Shortcomings in training and implementation.

An example in the figure 👇 Image
9/10: TAKE HOME MESSAGE

No more excuses...it is not justifiable to NOT prescribe exercise therapy in people with frailty. Image
10/10: If you found this post useful please share the first one and follow my page @a_bricca for more exercise science disseminated.

Thanks for reading it 🙏

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More from @a_bricca

Alessio Bricca Profile picture
Jun 21
#1 Walk away from low back pain 🚶‍♂️🚶‍♀️

This is what you should know when recommending walking as a treatment for recurrent episodes of low #backpain

Spoiler: It requires dedication and a structured approach for it to work.

🧵 Image
@exerciseworks @TheLancet #2 Nearly 70% of individuals recovering from a bout of low back pain will face another episode within the next year.
#3 Walking offers a safe form of exercise that fits seamlessly into hectic schedules and is available to nearly everyone, irrespective of financial standing or where we live.
Read 17 tweets
Alessio Bricca Profile picture
Apr 25
Physical inactivity is linked to the development of at least 35 chronic conditions.

The impact of movement on your well-being in this 🧵 https://journals.physiology.org/doi/full/10.1152/physrev.00019.2016
2/10 Physical activity is defined as any bodily movement produced by skeletal muscles that requires energy expenditure. Image
3/10 Progression to more severe pathobiology during continuous physical inactivity is slow and long in duration. Image
Read 10 tweets
Alessio Bricca Profile picture
Feb 21
The molecular mechanisms of exercise on tissue regeneration on the musculoskeletal, cardiovascular, and nervous system.

Discover the science behind 🏃‍♂️

🧵 Image
❤️ Heart

Exercise induces physiological hypertrophy of left ventricle and reduction of myocardial infarction area by promoting the proliferation of cardiomyocytes. Image
💪 Muscle

Exercise induces muscle hypertrophy by promoting the proliferation of the satellite cells in both physiological and pathological conditions.

Angiogenesis and mitochondrial biosynthesis are helpful in delaying muscle fatigue.
Read 10 tweets
Alessio Bricca Profile picture
Jan 10
Physical inactivity is a concern.

Understanding the motivators & barriers for #physicalactivity is crucial for effective lifestyle campaigns.

There is no one-size-fits-all solution but key recommendations include addressing fears, understanding individual preferences and...

🧵 Image
🔍 This thread is based on a systematic review that included 44 articles involving 28,583 subjects.

They identified a total of 61 motivators and 59 barriers for physical activity!

These included...

sciencedirect.com/science/articl…
Barriers and facilitator related to the Intrapersonal domain.

🚧 Health/physical impairment
🚧 Poor balance
🚧 Increased pain when exercising

👍 Physical/health benefits
👍 Better self image
👍 Higher self efficacy
Read 8 tweets
Alessio Bricca Profile picture
Jan 5
OSTEOARTHRITIS

Osteoarthritis is degenerative joint disease that leads to pain, stiffness and loss of function.

These are the latest insights into the pathogenesis and management of osteoarthritis.

🧵 https://www.nature.com/collections/jhgadjhbbd
@ArthritisFdn @arthritis_care @ArthritisSoc @ArthritisDigest In OA trials, understanding and managing 'placebo responses' is crucial.

To improve OA clinical trials, we need to grasp placebo responses, identify responders, and leverage insights for better outcomes.

Utilising placebo effects could enhance OA symptom management. https://www.nature.com/articles/s41584-023-01021-4
@Tuhina_Neogi Failed cartilage regeneration in injuries can lead to degenerative diseases.

Reasons include lack of regenerative cells, mechanical changes, inflammation, and metabolic shifts.

Effective treatments must address initial failure and disease stage. https://www.nature.com/articles/s41584-023-00979-5
Read 12 tweets
Alessio Bricca Profile picture
Jan 1
🏋️‍♀️ Exercise is mitochondrial medicine for muscle 💪

Let's dive into the fascinating world of mitochondria – the energy hubs that keep our #muscles going strong!🔋

Spoiler alert: #Exercise is a game-changer in tackling mitochondrial glitches, even without key regulators! 🏃‍♀️

🧵 https://www.sciencedirect.com/science/article/pii/S2666337619300083#bib94
2/10 With about 1200 proteins in their matrix, membranes, and intermembrane spaces, these unique organelles play a crucial role in generating ATP for cell survival. ⚡️

academic.oup.com/nar/article/44…
3/10 John Holloszy's 1967 classic publication convincingly showcased the muscle's adaptive response to regular exercise, revealing the impact of training on mitochondrial content. 🏋️‍♂️🔬 #ExerciseScience

sciencedirect.com/science/articl…
Read 10 tweets

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