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Nick Krontiris Profile picture
@nick_krontiris
May 30 • 9 tweets • 2 min read Twitter logo Read on Twitter
In this one, both an elevated lipid accumulation product (LAP) and an visceral adiposity index (VAI), were associated with an increased risk for early-onset type 2 diabetes among young Chinese adults.
- The lipid accumulation product (LAP) is a marker designed to measure cardiovascular disease risk factors that integrates waist circumference, an indicator of abdominal obesity, and triglyceride levels.
* LAP index (females)=TG (mmol/L)×(WC [cm]−58)

* LAP index (males)=TG (mmol/L)×(WC [cm]−65)
- The visceral adiposity index (VAI) is an indirect indicator of fat distribution and function.
* VAI = (WC/(39.68 + 1.88 × BMI)) × (TG/1.03) × (1.31/HDL) for men.

* VAI = (WC/(36.58 + 1.89 × BMI)) × (TG/0.81) × (1.52/HDL) for women.
- Patients in the 4th quartile of LAP and VAI had 2.257 and 4.705 times higher risk of type 2 diabetes before age 40, compared to those in the 1st quartile, respectively.
- A tenfold increase in LAP was associated with a decrease in type 2 diabetes onset age of 12.862 years in males and 6.507 years in females.
- A tenfold increase in VAI was associated with a decrease in type 2 diabetes onset age of 15.222 years in males and 12.511 years in females.
Comparison of lipid accumulation product and visceral adiposity index with traditional obesity indices in early-onset type 2 diabetes prediction: a cross-sectional study (open access)

doi.org/10.1186/s13098…

#Obesity #MetabolicSyndrome #InsulinResistance #Diabetes

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More from @nick_krontiris

Nick Krontiris Profile picture
Jun 1
In this one, a higher cardiovascular risk, as assessed by the Framingham 10‐year cardiovascular disease risk score, was associated with poorer cognitive function among older adults living in the US. Image
- The Framingham 10‐year cardiovascular disease risk score is based on age, sex, smoking, total cholesterol, high‐density lipoprotein‐cholesterol, blood pressure, and diabetes.
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Jun 1
In this one, HMB supplementation was associated with improvements in muscle strength, physical performance and muscle quality (defined as the handgrip strength/fat-free mass ratio) in older adults with sarcopenia during a resistance exercise program. Image
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- This study included subjects aged ≥60 years with sarcopenia which were assigned to the HMB group or the placebo group.
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Jun 1
This one found a bidirectional, dose-response relationship between handgrip strength and cognitive function in a multinational, European population with a mean age of 68.42 years. Image
- This study tried to analyze the longitudinal association between handgrip strength and cognitive performance in different cognitive functions according to sex in a European multicentric population.
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Nick Krontiris Profile picture
Jun 1
This systematic review and meta-analysis finds little evidence for or against recommending the dietary inclusion of legumes for the purpose of cardiovascular disease and type 2 diabetes prevention for healthy general populations.
- This study aimed to systematically review the evidence for associations between consumption of legumes and cardiovascular disease, type 2 diabetes and their risk factors among healthy adults using both observational and intervention studies.
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Nick Krontiris Profile picture
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- A genetic predisposition to high BMI is was found to be causally linked to a higher risk of developing psoriatic arthropathy and inflammatory spondylitis.
- For psoriatic arthropathy and gout, sex-specific effects were observed, and for osteoarthritis, the effect of BMI was stronger in premenopausal compared to postmenopausal women.
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