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https://twitter.com/KunstJonas/status/1382407699414061058The hallmark symptom of MECFS is that patients get *much* worse after physical exertion. Moreover, large patient surveys show that programs that require them to gradually increase their physical activities do not improve their condition but often lead to a permanent worsening. 2/
https://twitter.com/TimesONeill/status/1427555327734685700..are clear and need no further elaboration: For the past decades, proponents of the idea that people can treat or even cure ME through psychotherapy or graded exercise have failed to show that these treatments perform better than placebo. 2/
https://twitter.com/davidtuller1/status/1406335507953422336correction for multiple comparisons was not applied. The authors state: "Throughout this paper, we present unadjusted p-values. Methods for adjusting the family-wise error by methods such as the Bonferroni correction are known to be conservative..." 2/
https://twitter.com/PaulGarnerWoof/status/1377195611854934019For instance, adhering to unproven treatments can in the case of serious diseases such as cancer lead to a manifold risk of death. jamanetwork.com/journals/jamao… 2/