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Christian Ammitzbøll Profile picture
Christian Ammitzbøll
@RheumTweeter
Tweeting anything #Rheum #COVID19 MD | PhD | Clinical Associated Professor | Rheumatology #RheumTwitter #ACRAmbassador for #ACR22
Dec 3, 2022 • 10 tweets • 8 min read
#Methotrexate is the nr1⃣drug of choice for Rheumatoid #Arthritis.

MTX's history is eventful, and deserves a 🧵

🔹It started with childhood leukeamia
🔹Sleeping Beauty in the 1960-70's
🔹Awakened by Hoffmeister
🔹FDA👍1988 and 🔝 in the 1990's

1/🧵 #RheumTwitter #MedTwitter The start:
🔹1948, Dr Farber treated 5 children with #leukemia with Aminopterin, an anti-folate & precursor of #MTX, with outstanding results

🔹1951, first positive results of Aminopterin in #RA & #Psoriasis pts

Despite this, Aminopterin was aborted in RA

2/🧵 #RheumTwitter