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Jackie Parchem, MD Profile picture
Jackie Parchem, MD
@jackie_parchem
Physician-scientist @UTHealthObGyn • Maternal-fetal medicine specialist & advocate #pregnancy #covidvaccines #equity • Mom x 3 • Views my own
Dec 22, 2020 • 11 tweets • 8 min read
Pregnant and unsure about the #COVID19 vaccine? You’re not alone. Got vaccinated today at 31 weeks and feel very fortunate. But it’s complicated. Here’s why I decided to go for it. 1/ Context: I'm a high-risk pregnancy specialist & scientist so I've thought a lot about the vaccine and have discussed pros/cons at length w colleagues. Decision making in pregnancy is a complex process in general and highly personal. COVID vaccination is no exception. 2/
Dec 21, 2020 • 4 tweets • 4 min read
Excited to see our paper in @JCI_insight! Silver lining of lab shutdown this yr was time to wrap up this project which has been yrs in the making.

We studied a Stox1 KO mouse model to probe mechanisms underlying hypertensive disorders of #pregnancy. 1/
insight.jci.org/articles/view/… STOX1 is a TF and predicted #preeclampsia risk gene IDed through family-based genetic linkage studies (van Dijk, @NatureGenet 2005). A variant in the DNA-binding domain was proposed to alter protein function ➡️ preE susceptibility. But LOF model had not been studied. 🐁 2/