Melike Dönertaş Profile picture
Junior Group Leader @LeibnizFLI prev @EMBOFellows @MPIAGE @Cambridge_Uni @EMBLEBI @METU_ODTU @iscb @ekoevoder #aging #bioinformatics #microbiome #rstats
Feb 1, 2022 7 tweets 3 min read
Our latest work is now online @eLife! Studying gene exp. across #mice #lifespan, we show that tissues diverge from each other during #development but tend to converge back during #ageing - potentially losing tissue identity 🧵(1/n)
#aging #bioinformatics
elifesciences.org/articles/68048 (2/n) Studying gene expression trajectories, we found that developmental trajectories don't necessarily continue into ageing (gene expression trajectories show reversal). but, reversals were not shared across tissues 🤨