Discover and read the best of Twitter Threads about #lifespan

Most recents (9)

­čŤĹ30 y─▒l─▒ ge├žen bir zamand─▒r uzun ya┼čam, #lifespan #LONGEVITY sa─čl─▒kl─▒ ya┼čam ile u─čra┼č─▒yorum. Biohacker bile say─▒labilirim. Kendi ├╝zerimde DMSA(dimercapto succinic acid)+Alpha Lipoic Acid saatlik zaman kombinasyonu yapm─▒┼čl─▒─č─▒m var. Bu siklusu rahmetli Prof. Dr. Ahmet Ayd─▒n
(1)
ile beraber Cerrahpa┼ča Adli T─▒p Anabilim dal─▒nda yapm─▒┼čt─▒k.
Zaman zaman buradan sa─čl─▒kl─▒ yemekler payla┼č─▒yorum.
Beni yak─▒ndan takip edenlerin bildi─či gibi pesketaryan─▒m yani k─▒rm─▒z─▒ et, beyaz et, hayvansal bir g─▒da alm─▒yorum. Sadece bal─▒k ve yumurta yiyorum.
Bu─čday-bu─čday
(2)
├╝r├╝nleri, s├╝t ve s├╝t ├╝r├╝nleri, paketlenmi┼č, kutulanm─▒┼č hi├ž bir ┼čey sofram─▒zda yer almaz.
Bug├╝n sizlere ├žok k─▒s─▒k ate┼čte 47-50 dereceyi ge├žmeden pi┼čirdi─čim Somon bal─▒─č─▒ndan bahsedece─čim.
(Avlanma mevsimi hari├ž yaban─▒l bal─▒k da yemiyorum.)
Asla yap─▒┼čmaz tabanl─▒ her hangi bir
(3)
Read 10 tweets
"We evolved to be physically active. But most of us avoid physical activity."

The Active Grandparents Hypothesis

Daniel Lieberman, @Harvard

SFI Colloquium, streaming now:
"We evolved from #apes and apes are couch potatoes."

Daniel Lieberman, @Harvard

SFI Colloquium, streaming now:


#evolution #hominin #anthropology #physiology
"Your average hunter-gatherer walks from New York to LA every year."

Daniel Lieberman, @Harvard

SFI Colloquium, streaming now:
Read 24 tweets
­čŤĹResveratrol konusuna tekrar d├Âneyim.
Resveratrol i├žin #lifespan #longevity uzun ya┼čam ve sa─čl─▒kl─▒ hayat d├╝nyas─▒nda kirli ila├ž, dengesiz ila├ž (dirty drug) deyimi kullan─▒l─▒r.
─░ki formu bulunur.
Trans ve Cis formlar─▒.
Bu iki formun aras─▒ndaki kimyasal fark ile ba┼č─▒n─▒z─▒ ┼či┼čirmek(1)
istemem.
Bu y├╝zden k─▒saca Trans formunu, yani ├╝zerinde Trans Resveratrol yazan─▒ kullanman─▒z gerek diyerek i┼činize yarayan bilgiyi yazay─▒m.
Besin deste─či olarak sunulan Trans Resveratrollerin neredeyse hepsi Japon Mad─▒ma─č─▒ (Japanese Knotweed) bitkisinden elde edilir.
Yani (2)
resveratrol sadece k─▒rm─▒z─▒ ├╝z├╝m kabu─ču veya ├žekirde─činde bulunmaz. Ticari olarak daha dengeli ve karl─▒ ├╝retimi japon mad─▒mad─▒─č─▒ndan elde edilenidir.
Resveratrol ya─čda ├ž├Âz├╝nen bir maddedir. Dolay─▒s─▒yla sadece su ile i├žmek emilimini azalt─▒r. En iyisi resveratrol├╝ bir miktar (3)
Read 13 tweets
Our latest work is now online @eLife! Studying gene exp. across #mice #lifespan, we show that tissues diverge from each other during #development but tend to converge back during #ageing - potentially losing tissue identity ­čžÁ(1/n)
#aging #bioinformatics
elifesciences.org/articles/68048
(2/n) Studying gene expression trajectories, we found that developmental trajectories don't necessarily continue into ageing (gene expression trajectories show reversal). but, reversals were not shared across tissues ­čĄĘ
(3/n) We, then, hypothesised that reversals may contribute to tissue divergence during development while they are gaining a "tissue identity" but convergence during ageing as they lose their tissue-specific expression signatures ­čĄö
Read 7 tweets
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging
aging-us.com/article/203736ÔÇŽ
@AgingJrnl
Alternatively, you could go with something like this:

Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeast
biorxiv.org/content/10.110ÔÇŽ
#aminoacids #lifespan #chonological #age
And this:

Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity
researchgate.net/publication/25ÔÇŽ

#longevity #age #lifespan
Read 10 tweets
"All my friends are dying.",
I realized as I lay on the floor contemplating how to live to 100.

I am dramatic
and obsessed with longevity.
Dramatically obsessed with #healthspan
not #lifespan.

I'm on a quest to live well for a century.

Here's the problem:
­čžÁ
#ship30for30
The problem:
I have no idea what health actually means.

Do we eat meat or not?
Does dairy actually cause cancer?
What about mercury in fish?
Is coffee good or bad?

There's too much conflicting information,
too many buzzwords
and @instagram was making it worse.

#Tweet100
Frustrated, I decided to look at the places where people DID live to 100.
At least I could begin there. These places are called @BlueZones.

Dan Buettner's work studies the world's longest-lived populations and finds best practices.

Turns out, there are only 5 blue zones:
Read 10 tweets
Arlan Richardson showing that JAX-housed mice, like humans, have undergone a dramatic improvement in #lifespan this century ... by reducing deaths from pathogens. #MindYourModels
Recommends looking at lifespan data as the best indicator of husbandry quality at different institutions/sources. Mean survival should be at least 27-30 months.
Example: 2003 Igf1r study showing 33% lifespan extension (in het ÔÖÇ´ŞĆs), but mean lifespan of controls was only 19mos. Lifespan effect largely disappeared when replicated in cohorts with longer control lifespan.
This was my go-to question for fly lifespan studies as a postdoc.
Read 7 tweets
I'm often asked how to learn about #AgingBiology, which I hope this thread can address.

Will first list recommended introductory resources, then contextualize and interpret.
There's exciting progress! But also many fanciful ideas, so you can't take everything at face value.
Will mostly skip the Why/philosophy of #AntiAging, since those asking for resources are likely already bought in.

If interested I wrote a Why/Why not post back in 2016: martinborchjensen.com/hypotheses/agiÔÇŽ, and most of the websites I'll list have a version of this discussion too.
The most comprehensive #Aging primer is @ArtirKel's FAQ: nintil.com/longevity.
It does a great job of introducing the field, and distilling the science for non-biologists. Bonus points for contextualizing how biology is different from engineering.
Read 13 tweets
1/Short thread on #Longevity
Longevity is a complex challenge, it appears that humans have a rough cap to #lifespan at about 120 years of age (even if you eat healthy, exercise and get lucky with great genes and a great environment).
2/ So the question is how can we fundamentally move past the 120 year cap? #longevity #lifespan
3/ There's promising data around #calorierestriction and #MTOR activating molecules like #rapamycin, which in other species can extend #lifespan by 10-15% (which if we're lucky, for the few it might extend the human lifespan cap to 132-138 years of age). discovermagazine.com/mind/the-two-fÔÇŽ
Read 7 tweets

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