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https://twitter.com/DBDouble/status/16204524795562926102/ Like Bleuler's "group of schizophrenias," mental disorders are wastebasket categories that likely represent many different biopsychosocial pathways to a given constellation of symptoms.
https://twitter.com/doctorid/status/15536501287954513922/ And so, the monoamine theory was born out of the observed efficacy of MAOIs and TCAs. Prozac was developed more deliberately as a serotonergic drug, but this was done more to reduce the side effect burden of ADs than based on any premise of a serotonergic theory of depression.
https://twitter.com/psychunseen/status/1471858981740158979?s=202/