Interesting how the envelope (A) and spike (E) genes of SARS-CoV-2 & RaTG13 but not the membrane or nucleocapsid genes segregate outside all bat CoVs with respect to codon usage?
This is behavior of a synthetic gene, constructed for improved laboratory amplification.
Every single bat CoV hates the CGG codon. Every. single. one.
1/ Here is a thread of the slides from my recent YouTube video on the evidence against a market origin of SARS-CoV-2. #COVID19#COVID#SARSCoV#OriginOfCovid2/
Sep 15, 2021 • 6 tweets • 1 min read
Facts 1. CoV outbreak near CoV research institute (the John Stewart effect) of CoV found >1000 km to the south in nature but 96% match at WIV 2. No animal from market, city, province, or all of China with CoV. 80,000 tested 3. Single 'Virus Zero' with no posterior diversity
4. No pre-epidemic seroconversion. 9000+ tested 5. Spike Protein S1/S2 furin site never seen before in >1000 sarbecoviruses 6. CCG-CCG codon dimer never seen before in >1000 sarbecoviruses. 7. Recombination across subgenera to solve #5 & #6 either prohibited or rare.
May 27, 2021 • 4 tweets • 1 min read
For the non-scientist who might be confused by the CoV-2 origin debate, a proper sentence by a scientist has two parts. The first part is the data, the observation; the second part is the conclusion that follows from the data.
Examples: #COVID19
Based on testing 80,000 animals and finding no CoV-2 in any of them, one can conclude from statistics that the prevalence of CoV-2 where the testing was done must be less than 0.0004%.
Mar 23, 2021 • 7 tweets • 2 min read
I agree this is not an example of codon optimization for the same reason; it is done over a larger region.
But natural selection in betacoronaviruses has NEVER produced a -CGG-CGG- dimer codon pair. Repeating: there has never been this codon dimer in a coronavirus from nature.
So after scanning 580,000 betacoronavirus codons you suddenly have a -CGG-CGG- cannot be waved away with the 'sh#@' happens hypothesis. Remember, codons have a matching tRNA so putting the two rarest codons together is going to slow/stall transcription.
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