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Sean Ong Profile picture
Sean Ong
@seanongwx
ID doctor from Singapore and joint PhD candidate at @ihpmeuoft and @UniMelbMDHS. Working on novel approaches in clinical trial design in bloodstream infections.
Aug 24, 2021 • 9 tweets • 6 min read
1/ Hot off the press - our study comparing Alpha, Beta, and #Delta VOCs, showing that #DeltaVariant infection was associated with more severe disease, higher viral load, and a longer duration of viral shedding.

@IDSAInfo #IDTwitter #COVID19 #SARSCoV2
doi.org/10.1093/cid/ci… 2/ The effect on severity was seen in both an analysis of Singapore's national-level data (increased odds of O2 requirement, ICU admission, and mortality), as well as a detailed analysis of an #NCID cohort (increased odds of both pneumonia and severe disease).
Aug 10, 2021 • 7 tweets • 3 min read
1/ Our paper is now published in final peer-reviewed form in CID! In this study, we recruited 22 #COVID19 patients at NCID and collected breath samples using a G-II machine while they were talking, breathing, and singing.
@IDSAInfo @drkristenkc @Don_Milton
doi.org/10.1093/cid/ci… 2/ 13 (59%) of patients had detectable #SARSCoV2 RNA by PCR in exhaled breath samples, with 85% comprising fine aerosols <5um. There was significant variation between patients, with 2 patients accounting for 52% of the total viral load - may explain so-called "super-emitters".