Discover and read the best of Twitter Threads about #NINDSFellow
Most recents (1)
🚨 Alert! We are excited to share our new preprint in which we define the roles of individual class I molecules on brain endothelium in the regulation of T cell responses and development of neuropathology in experimental cerebral malaria
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
CD8 T cell engagement of brain vasculature has been implicated in the neuropathology of cerebral malaria. In this work we interrogated human and mouse data during infection and noted upregulation of activation and Ag-presentation molecules or transcripts in brain endothelium 
When either class I was ablated, the mice were normal at baseline and also established normal peripheral plasmodium infection and peripheral immune responses. However, T cell interactions with brain endothelium were disrupted during infection
