Prof. Akiko Iwasaki Profile picture
We study antiviral immunity and viral disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII

Feb 15, 2020, 6 tweets

There is an urgent need to generate effective vaccine against #SARSCoV2. This is such an important topic, and many agencies/labs/companies are working on it. I want to open up this discussion here. Let's unite towards this goal.

Pls RT, chime in with your insights/thoughts.

1/n

Learning from previous #CoV studies, what is likely to be the correlate of protection? What vaccine approaches generate best neutralizing antibody (Ab)? How quickly does #CoV generally mutate away from Ab-mediated recognition?

2/n

What would be a good preclinical model to test vaccine efficacy against #CoV? How well do antibodies to previous #CoVs cross-react against other members including #SARSCoV1, #MERSCoV and #SARSCoV2?

3/n

BTW, if you are interested in doing research on #SARSCoV2 vaccines, pathogenesis and related topics, @NIAIDFunding released this last week 👇🏽

4/n

grants.nih.gov/grants/guide/n…

@NIAIDFunding I just read this timely and useful summary of various companies and academic labs developing #COVID19 vaccines in @BioCentury. Adding this to my thread.

WHO mapping out COVID-19 vaccines

5/n

biocentury.com/article/304456

@NIAIDFunding @BioCentury For researchers interested in studying #SARSCoV2, @CDCgov has deposited viral isolates to BEI Resources 👇🏽

6/n

cdc.gov/coronavirus/20…

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