Good news! This new human #tumor microbiome study is excellent. They used hundreds of negative controls for contamination + an extensive combo of methods to identify #bacteria in 7 #cancer types (lung, ovary, pancreas, melanoma, bone, brain): science.sciencemag.org/content/368/64…
2/ Bacterial LPS + 16SrRNA were frequently detected in all tumor types, w/ #breast cancer harboring a particularly rich and diverse #microbiome. The image below shows LPS/16SrRNA in breast cancer cells. Bacteria were also found in normal breast samples from healthy subjects
3/ In one experiment the team grew live #bacteria from three main phyla (Proteobacteria, Firmicutes, Actinobacteria) from fresh breast #tumor samples collected from women undergoing breast surgery
4/ Transmission electron #microscopy (TEM) clearly demonstrated that bacteria in four selected breast tumors were intracellular. In fact, the #bacteria may have altered their envelope, perhaps leading to a cell wall deficient state akin to L-forms
5/ Some identified bacteria such as Fusobacterium nucleatum (found in breast, #colorectal, #pancreatic tumor cohorts) likely contribute to driving cancer progression, while activity of many identified bacteria in relation to #tumor growth must still be further studied
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