Discover and read the best of Twitter Threads about #microbiome

Most recents (24)

Got leaky gut and worried about Lipopolysaccharides (LPS) causing an immune response that leads to systemic inflammation? Well you should be! But let's talk about what a ketogenic diet can do to mitigate that for you. Shall we? 🧵(1/21)
A #leakygut is a condition in which the lining of the intestine becomes damaged or compromised, allowing toxins, undigested food particles, and harmful bacteria to enter the bloodstream. (2/21)
When this happens, large amounts of LPS (lipopolysaccharide) can be released into the bloodstream, triggering an #immune response and #inflammation in the body. (3/21)
Read 21 tweets
Persistent childhood viruses are found in adult tissues, including internal organs, indicating the existence of a unique microbiome in our organs- the virome.…
@lpyori @DgPratas @MariToppinen @Espoonklaussi @SajantilaAntti @MaFePerdomoC Image
Bacteriophages can be robustly detected in microbiome samples like feces or skin swabs. But identifying latent viruses remains a challenge, as they can slumber as episomes or integrated within cells and tissues without actively replicating.
As these viruses are intracellular they are not restricted to body's outer surfaces where most other microbiotas dwell.
Read 16 tweets
26/50 The detected "SV40 promoter with 72bps indel" is a "nuclear localization signal" that means either the #plasmid or one of its expressed proteins can be transported into host cell nuclei,...
27/50 ...where the host DNA is found, creating an open question of whether host DNA interaction will occur and to what effect e.g. integration with human DNA.…
28/50 Potential effects of plasmid #contamination in vivo? Notable, five chemistry professors from German universities have been studying #Pfizer #BionTech's covid vaccine. They addressed some questions to the company. Where does the gray tone come from?…
Read 29 tweets
Wanna see something weird?! Ever thought about this? Every 2nd animal is a fish.
Despite this fact, much about the #microbiome in fish is unknown!
How is the #metagenome in Norwegian wild Atlantic #salmon as a case? In one word - surprising!

Here is a thread! (1/10)
We have used genome-resolving metagenomics to discover some wild and surprising interactions
between 🐟 and 🦠 in Atlantic salmon featured in @ISME_microbes
Please have a read: (2/10)
The first surprise we encountered was the simplicity of the microbiome of wild salmon! One 🦠 ruled over all the others no matter the sampling location - despite this being across 700 Km! (3/10)
Read 11 tweets
1/5 "In healthy individuals, normal #body #temperature is variable and has decreased consistently since the 1860s."…
2/5 "The #gut #microbiome is a key modulator of body temperature variation both in #health and critical illness, and is thus a major, understudied target for modulating #physiologic #heterogeneity in #sepsis."
3/5 The Carrington Event was the most intense geomagnetic storm in recorded history, peaking from September 1 to September 2, 1859 during solar cycle 10.
Read 5 tweets
Sharon Irving, CRNP, MSN, PhD, PNP starting off the afternoon nutrition lecture with why we call it NUTRITION THERAPY. #SCCM2023 #ICUNutrition
Lots of metabolic changes in critical illness that prevent adequate prevention on nutrition. #SCCM2023 #ICUNutrition
Irving: depriving the gut of EN causes problems. Failing to maintain gut mucosa and microbiome causes shifts in homeostasis. #SCCM2023 #ICUNutrition
Read 10 tweets
1/: About 70% of the immune system is housed in the gut. And yet, both our digestive and immune systems were largely ignored during the 𝘱𝘭𝘢𝘯𝘥𝘦𝘮𝘪𝘤. In this 𝗧𝗛𝗥𝗘𝗔𝗗, I will briefly tell you things the government won’t tell you. Image
2/: The gut is home to billions of microorganisms (i.e. bacteria, viruses etc.) that are of central importance to us. This community of organisms is called the "microbiome". The #microbiome may weigh as much as five pounds (i.e. 2.5kg). Image
3/: With a surface area of 400m², the gut mucosa is one of the largest components of the human immune system. Its function is to absorb nutrients while making sure that pathogens won't enter the bloodstream. Image
Read 25 tweets
Merci aux australiens de produire cette excellente publication qui apporte un éclairage complémentaire sur ce maudit virus, la translocation microbienne et le métabolisme du tryptophane @rupertleong #microbiome… #kynureninepathway #longcovid 1/x
L'enjeu de la fonctionnalité de la barrière épithéliale et du métabolisme du tryptophane constitue un facteur de gravité de l'infection à covid 19 mais aussi de sa résolution. 2/x
Au regard du vécu patient, on peut dire que cela va dans les 2 sens. Le sars-cov a une capacité à altérer les jonctions serrées mais l'altération des jonctions serrées est aussi une cause pour faire un "mauvais covid" mais aussi de compliquer la guérison 3/x
Read 13 tweets
🚨New paper in @Nature reveals link between #microbiome & #exercise motivation!🧠🐁

👉Provides foundational insight that could lead to dietary practices & supplements to promote exercise motivation



1/ Thread🧵👇
2/ The study in question is a mouse study, as you can really perform these fine mechanistic study in animal models

Data show that genetics variation among mice was a minor contributor and the variations in microbiome composition were more important for physical performance...
3/ To show the microbiome mediates the effects, they knocked out the microbiome with antibiotics in high-performer mice and the result was an impairment physical performance by 50%! (2a)

By contrast, microbiome transplant could enhance performance.
Read 10 tweets
I gave a talk on inpatient bowel regimens today for the @YaleMed @YaleIMed residents and students, with additional 💎s on outpatient #constipation. Here are the slides!

💩 💩 💩

#MedTwitter #GITwitter #motility #MedEd @YaleIM_Chiefs @MayoClinicGIHep
Most inpatients require a bowel regimen. Our patients typically have most of the risk factors for #constipation!
#Constipation is more about symptoms than frequency! 🚽

It’s also a *symptom* (like chest pain), so need to figure out what’s causing it and treat accordingly.
Read 20 tweets
We are excited to share our new work @Nature, led by @Lenka_Dohnal, uncovering a gut-brain pathway that regulates the motivation for #exercise. (1/7)…
We assessed the exercise capacity of a large cohort of deeply-profiled genetically-diverse mice and identified the gut #microbiome as an important contributor to exercise performance. (2/7) Image
Using exercise experiments in germ-free mice, we identified several bacterial species that can drive physical activity. (3/7) Image
Read 10 tweets
💨The gut microbiota generates ~0.2L–1.5L of gas per day
💨>99%: hydrogen (H2), carbon dioxide (CO2), & methane (CH4)– *odorless*
💨foul smell of gas from <1%: sulfur–containing gases hydrogen sulfide (H2S), methanethiol (CH3SH), dimethyl sulfide [(CH3)2S] + volatile compounds
🦠bacteria in the colon ferment substrates that are not digested or absorbed in the upper GI tract (e.g. carbohydrates, proteins, fats)
🦠produce short-chain fatty acids, branched-chain fatty acids, ammonia, N-nitro compounds, phenolic and indolic compounds, and various gases
Read 15 tweets
The Effect of #Glyphosate on the #Gutmicrobiome and Neurocognitive Function…
1/5 Glyphosate is the active ingredient in the herbicide #RoundUp. In 1996 #geneticallymodified soybeans that could tolerate Round Up were introduced. At that time, Round Up made up just 3.8% of herbicides in use. By 2007 glyphosate use was more than double the next herbicide.
2/5 Glyphosate blocks an enzyme used by plants, bacteria, fungi, and algae, including beneficial bacteria in our #gut. Pathogenic bacteria Clostridia and Salmonella are not affected by glyphosate, allowing them to survive.
Read 6 tweets
Have you ever wished to sequence SPECIFIC bacteria but NOT the vast background in #microbiome? Today, we introduce *mEnrich-seq*: #methylation-guided enrichment sequencing of bacterial taxa of interest from microbiome. 4yr project led by @clannabel7!…🧵1/10
#Metagenomic sequencing throughput is largely consumed by abundant microbes while those with relatively lower abundance cannot be sequenced in a cost-effective manner, due to the highly skewed abundance distribution of diverse bacteria and host DNA. 2/10
Although several methods have been developed (pls see Introduction in preprint) to exclude host DNA and/or the highly abundant microbes, there are still key challenges in achieving high enrichment efficiency and differentiating between bacterial taxa w/ very similar genomes. 3/10
Read 10 tweets
"The 21st Century Question: Emergently Engineering the Future"

Follow this 🧵 today and tomorrow for highlights from our 2022 #AppliedComplexity Network and Board of Trustees Symposium:…

#Web3 #Cities #Polarization #EmergentEngineering #Decentralization
We start with a talk by SFI President David Krakauer:

"Would anyone care to guess why we're so GOOD at building transistors and so CRAP at designing drugs?"

"This thing [points to transistor] lives in a centralized system. This thing [points to cancer drug] lives in US."
"I'm going to pick on economics, because we like to do that at SFI. 'Ooh, look at that cover! So techy. Global, heat maps...' But here's 'Networks' [in the textbook]. THAT'S IT. Here's '#ComplexityEconomics.' NOTHING."
Read 111 tweets
Incredibly happy to have this paper out! We demonstrated that cocaine exposure affects gut microbiota composition and that this compositional change modulates neurobehavioral plasticity:… @cellhostmicrobe #gutbrain #microbiome #OpenAccess
A long thread😅
Thanks to all the co-authors! @pauburdisso and of course @VanessaSperand2. Also, the twitterless Amir Segev and Said Kourrich. @TheEllermannLab and @AGJimenezLopez thanks for all the feedback!
Cocaine and other psychostimulants act by blocking catecholamine reuptake. Citrobacter rodentium is a mouse γ-Proteobacteria that can sense host norepinephrine to colonize the gut, inducing dysbiosis.
Read 14 tweets
Microbiota-based therapeutics in the treatment of recurrent Clostridioides difficile 🦠

@DrPaulGastro @Khanna_S @caterina_oneto

#MedTwitter #GITwitter #IDTwitter #ACG2022 #Cdiff
Pathogenesis of CDI
1. Disruption of #microbiome (antibiotics) ▶️ loss of colonization resistance
2. Colonization
3. Spore ▶️ vegetative ▶️ toxin
4. Recurrence cycle or restoration of microbiota
Antibiotics control acute disease, but do not protect against recurrence
Read 26 tweets
It's not just what you eat that influences your #gut #microbiome, but also the medication (not just antibiotics).

We now need to be thinking about that more carefully when studying #diet, #prebiotics, #probiotics, #gutbrainaxis and the #microbiota


"Individuals exposed to multiple drugs, polypharmacy, showed distinct gut microbiome structures harboring significantly more abundant upper gastrointestinal species and several nosocomial pathobionts due to additive drug effects."
"Polypharmacy was also associated with microbial functions, including the reduction of short-chain fatty acid metabolism and increased bacterial stress responses."
Read 4 tweets
Sometimes something so cool comes out I can't wait until a Live Brain Fog Recovery Program Lesson to share some of the scientific reasons for doing the program! So here it goes... 🧵
In a recent study on the diet-microbiome-gut-brain nexus in acute and chronic brain injury, findings have shown that the microbiome is affected by neurodegenerative conditions and brain injury states.
While the specific changes to the microbiomes of people suffering from different neurological disorders vary, there is a theme seen in both acute and chronic brain injury. And that theme is that pathogenic and opportunistic bacteria increase and beneficial flora becomes depleted.
Read 5 tweets
Eating 30 different plants every week can make life MUCH better.

By increasing the diversity of your #microbiome, you improve #guthealth and strengthen the #gutbrainaxis


This 🧵 will explain, why it's true and how I do it over the next week. 👇
Remember, plants include fruits, vegetables, grains, legumes, nuts and seeds.

#30plantchallenge Here we go!!
Read 30 tweets
This is one of the most concerning examples of #SARS-CoV-2 persistence to date 👉 The team found SARS-CoV-2 RNA + Spike protein in the stool of 11/14 newborn babies born to mothers who had #COVID-19 resolve 10+ weeks before delivery:…
2/ The team concludes that “the findings suggest in utero transmission of SARS-CoV-2 and possible persistent intestinal #viral reservoirs in the newborns”
3/ It is important to note that all newborns that harbored SARS-CoV-2 in stool were negative for the #virus via nasal PCR. The team also found that stool homogenates from all 14 newborns in the study elicited elevated inflammatory IL-6 + IFN-γ from macrophages
Read 7 tweets
🚨Non-nutritive #sweeteners (saccharin, sucralose, stevia, aspartame) alter the human gut & oral #microbiome, leading to personalized detrimental impacts on glucose tolerance: our new RCT with @Yot_Coh @Elinav_Lab is out now in @CellCellPress! 1/🧵…
Sugar consumption is strongly linked to cardiometabolic disease risk. Are non-nutritive sweeteners the answer? As we @acritschristoph @yerpal_mxval @lilyklau recently reviewed, the literature is highly conflicted. The microbiome may be the solution...🧵2/n… Image
Our @EranElinav @Elinav_Lab 2014 report in @Nature was the first to demonstrate that disruption of gut bacteria (microbiome) by non-nutritive sweeteners causes glucose intolerance and that in humans, the microbiome may modulate personalized risk... 3/🧵…
Read 8 tweets
⭐️Everything you need to know about H. pylori: the Maastricht V/Florence Consensus Report summarized❗️ 🧵


#MedTwitter #GITwitter #IDTwitter #microbiome…
🦠HP gastritis is an infectious disease irrespective of symptoms/complications

⚠️HP▶️chronic active gastritis in ALL colonized individuals. This can▶️peptic ulcer disease, atrophic gastritis, gastric adenocarcinoma, MALT. Eradication prevents all of this
🦠Test-and-treat (versus endoscopy or empiric PPI) for uninvestigated dyspepsia. Subject to regional HP prevalence and 💰considerations. This does NOT apply to patients with 🚩symptoms or older patients.

⚠️Need EGD if🚩. Can also consider🔦in patients where HP prevalence is ⬇️
Read 63 tweets

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