Discover and read the best of Twitter Threads about #microbiome

Most recents (24)

The Effect of #Glyphosate on the #Gutmicrobiome and Neurocognitive Function
sciencedirect.com/science/articl…
1/5 Glyphosate is the active ingredient in the herbicide #RoundUp. In 1996 #geneticallymodified soybeans that could tolerate Round Up were introduced. At that time, Round Up made up just 3.8% of herbicides in use. By 2007 glyphosate use was more than double the next herbicide.
2/5 Glyphosate blocks an enzyme used by plants, bacteria, fungi, and algae, including beneficial bacteria in our #gut. Pathogenic bacteria Clostridia and Salmonella are not affected by glyphosate, allowing them to survive.
Read 6 tweets
Have you ever wished to sequence SPECIFIC bacteria but NOT the vast background in #microbiome? Today, we introduce *mEnrich-seq*: #methylation-guided enrichment sequencing of bacterial taxa of interest from microbiome. 4yr project led by @clannabel7! biorxiv.org/content/10.110…🧵1/10
#Metagenomic sequencing throughput is largely consumed by abundant microbes while those with relatively lower abundance cannot be sequenced in a cost-effective manner, due to the highly skewed abundance distribution of diverse bacteria and host DNA. 2/10
Although several methods have been developed (pls see Introduction in preprint) to exclude host DNA and/or the highly abundant microbes, there are still key challenges in achieving high enrichment efficiency and differentiating between bacterial taxa w/ very similar genomes. 3/10
Read 10 tweets
"The 21st Century Question: Emergently Engineering the Future"

Follow this 🧵 today and tomorrow for highlights from our 2022 #AppliedComplexity Network and Board of Trustees Symposium:

santafe.edu/events/annual-…

#Web3 #Cities #Polarization #EmergentEngineering #Decentralization
We start with a talk by SFI President David Krakauer:

"Would anyone care to guess why we're so GOOD at building transistors and so CRAP at designing drugs?"

"This thing [points to transistor] lives in a centralized system. This thing [points to cancer drug] lives in US."
"I'm going to pick on economics, because we like to do that at SFI. 'Ooh, look at that cover! So techy. Global, heat maps...' But here's 'Networks' [in the textbook]. THAT'S IT. Here's '#ComplexityEconomics.' NOTHING."
Read 111 tweets
Incredibly happy to have this paper out! We demonstrated that cocaine exposure affects gut microbiota composition and that this compositional change modulates neurobehavioral plasticity: sciencedirect.com/science/articl… @cellhostmicrobe #gutbrain #microbiome #OpenAccess
A long thread😅
Thanks to all the co-authors! @pauburdisso and of course @VanessaSperand2. Also, the twitterless Amir Segev and Said Kourrich. @TheEllermannLab and @AGJimenezLopez thanks for all the feedback!
Cocaine and other psychostimulants act by blocking catecholamine reuptake. Citrobacter rodentium is a mouse γ-Proteobacteria that can sense host norepinephrine to colonize the gut, inducing dysbiosis.
Read 14 tweets
Microbiota-based therapeutics in the treatment of recurrent Clostridioides difficile 🦠

@DrPaulGastro @Khanna_S @caterina_oneto

#MedTwitter #GITwitter #IDTwitter #ACG2022 #Cdiff
Pathogenesis of CDI
1. Disruption of #microbiome (antibiotics) ▶️ loss of colonization resistance
2. Colonization
3. Spore ▶️ vegetative ▶️ toxin
4. Recurrence cycle or restoration of microbiota
Antibiotics control acute disease, but do not protect against recurrence
Read 26 tweets
It's not just what you eat that influences your #gut #microbiome, but also the medication (not just antibiotics).

We now need to be thinking about that more carefully when studying #diet, #prebiotics, #probiotics, #gutbrainaxis and the #microbiota

#Gastroenterology

@gerdosi
"Individuals exposed to multiple drugs, polypharmacy, showed distinct gut microbiome structures harboring significantly more abundant upper gastrointestinal species and several nosocomial pathobionts due to additive drug effects."
"Polypharmacy was also associated with microbial functions, including the reduction of short-chain fatty acid metabolism and increased bacterial stress responses."
Read 4 tweets
Sometimes something so cool comes out I can't wait until a Live Brain Fog Recovery Program Lesson to share some of the scientific reasons for doing the program! So here it goes... 🧵
In a recent study on the diet-microbiome-gut-brain nexus in acute and chronic brain injury, findings have shown that the microbiome is affected by neurodegenerative conditions and brain injury states.
While the specific changes to the microbiomes of people suffering from different neurological disorders vary, there is a theme seen in both acute and chronic brain injury. And that theme is that pathogenic and opportunistic bacteria increase and beneficial flora becomes depleted.
Read 5 tweets
Eating 30 different plants every week can make life MUCH better.

By increasing the diversity of your #microbiome, you improve #guthealth and strengthen the #gutbrainaxis

#30plantchallenge

This 🧵 will explain, why it's true and how I do it over the next week. 👇
Remember, plants include fruits, vegetables, grains, legumes, nuts and seeds.

#30plantchallenge Here we go!!
Read 30 tweets
This is one of the most concerning examples of #SARS-CoV-2 persistence to date 👉 The team found SARS-CoV-2 RNA + Spike protein in the stool of 11/14 newborn babies born to mothers who had #COVID-19 resolve 10+ weeks before delivery: nature.com/articles/s4139…
2/ The team concludes that “the findings suggest in utero transmission of SARS-CoV-2 and possible persistent intestinal #viral reservoirs in the newborns”
3/ It is important to note that all newborns that harbored SARS-CoV-2 in stool were negative for the #virus via nasal PCR. The team also found that stool homogenates from all 14 newborns in the study elicited elevated inflammatory IL-6 + IFN-γ from macrophages
Read 7 tweets
🚨Non-nutritive #sweeteners (saccharin, sucralose, stevia, aspartame) alter the human gut & oral #microbiome, leading to personalized detrimental impacts on glucose tolerance: our new RCT with @Yot_Coh @Elinav_Lab is out now in @CellCellPress! 1/🧵
authors.elsevier.com/c/1fcJDL7PXipT…
Sugar consumption is strongly linked to cardiometabolic disease risk. Are non-nutritive sweeteners the answer? As we @acritschristoph @yerpal_mxval @lilyklau recently reviewed, the literature is highly conflicted. The microbiome may be the solution...🧵2/n ncbi.nlm.nih.gov/pmc/articles/P… Image
Our @EranElinav @Elinav_Lab 2014 report in @Nature was the first to demonstrate that disruption of gut bacteria (microbiome) by non-nutritive sweeteners causes glucose intolerance and that in humans, the microbiome may modulate personalized risk... 3/🧵 nature.com/articles/natur…
Read 8 tweets
⭐️Everything you need to know about H. pylori: the Maastricht V/Florence Consensus Report summarized❗️ 🧵

🦠🦠🦠🦠🦠🦠🦠🦠🦠🦠🦠🦠

#MedTwitter #GITwitter #IDTwitter #microbiome

gut.bmj.com/content/71/9/1…
INDICATIONS/ASSOCIATIONS
🦠HP gastritis is an infectious disease irrespective of symptoms/complications

⚠️HP▶️chronic active gastritis in ALL colonized individuals. This can▶️peptic ulcer disease, atrophic gastritis, gastric adenocarcinoma, MALT. Eradication prevents all of this
🦠Test-and-treat (versus endoscopy or empiric PPI) for uninvestigated dyspepsia. Subject to regional HP prevalence and 💰considerations. This does NOT apply to patients with 🚩symptoms or older patients.

⚠️Need EGD if🚩. Can also consider🔦in patients where HP prevalence is ⬇️
Read 63 tweets
Let’s talk about #mouthhygiene and the lies the #dental industry believes in and preaches… 🧵

First lie (picture below)…#fluoride
When you brush your teeth, tongue and gums with #fluoridated #toothpaste, #fluoride is absorbed into the soft tissues of your mouth. You absorb fluoride through your gums into the inner dentin of your teeth, weakening the dentin and making it chalky from the inside out.
To top it all off, whatever fluoride in toothpaste which adheres to our teeth after we “rinse out” is swallowed sooner or later. Dental gels and varnishes also wash off and are swallowed…
All forms of fluoride harm the body and should be avoided.
Read 17 tweets
Now we'll talk #polyphenols and #PrecisionNutrition in this next science packed session at #Nutrition2022. #NutritionLiveOnline Image
Oh look the #microbiome is here too! 🥰👏🥳 Yes, polyphenols are key to the #GutMicrobiome. Let's learn more.
#Nutrition2022 #NutritionLiveOnline Image
But first the #metabolome and polyphenols. #Nutrition2022 #NutritionLiveOnline Image
Read 12 tweets
Good morning! Starting day 2 with another of my favorite #nutrition topics: the food matrix. What does that mean for #health? Food is not simply the sum of its parts. 🤓
#Nutrition2022 #NutritionLiveOnline Image
First up, one of my colleagues in nutrition and the #gut #microbiome, @HolscherLab. Let's #science!
#Nutrition2022 #NutritionLiveOnline Image
The matrix of foods affects the bioaccessibility of nutrients.
#Nutrition2022 #NutritionLiveOnline Image
Read 10 tweets
Kicking off #Nutrition2022 with the Presidential Symposium, "#Precision #Nutrition: New Scientific Horizons."
#NutritionLiveOnline Image
Quite the lineup for the opening session! Image
The #nutrition for #precision #health is an initiative from @NIH via the @AllofUsResearch Research Program. Image
Read 16 tweets
1/Q: Did getting exposed to fewer germs for the last 2 years weaken our immune systems?

We've been hearing this question a lot.
dearpandemic.org/fewer-germ-exp…
2/ Not likely. If your kids are suddenly getting sick a lot, this is likely due to “catching up” on exposures rather than a weakened immune system.
3/ Many families w/ young kids have been hunkered down for the better part of 2 years– a good % of a young child’s entire life. While isolation had *many* downsides, we can agree that not having to suction snot out of infant noses or clean up norovirus puke was a happy upside.
Read 18 tweets
🌬️ Breath testing for #SIBO: everything you need to know! 🎈 😮‍💨 💩 🦠 🐄 📈

#MedTwitter #medicine #science #GITwitter #GI #microbiome #IBS #diet #nutrition

cghjournal.org/article/S1542-…
To kick things off: how do you diagnose #SIBO?
#SIBO is a disorder characterized by excessive colonization of the small intestine by organisms usually found in the colon, especially Gram-negative bacteria.

(NB: the more we learn, it seems the *type* of bacteria is more important than the *number!*)
Read 26 tweets
While #science thought us that we can even cut and paste #genes with #CRISPR technology…even with that we only influence 3% to 5% of #chronicillness. The rest depends on #how you #live your #life!!! So how do we #SelfRegulate our #body?
1. Good #sleep is more important than most think! What happens during sleep? The fluctuation of consciousness…that we call the waking state. But in many wisdom traditions of the world, the waking state is merely a lucid dream that consciousness is having…
Read 41 tweets
The Gut #Microbiome is implicated in the pathogenesis of inflammatory arthritides & other health conditions

Gut dysbiosis is a broad term relating to an 'imbalance' of gut microbiota associated with an unhealthy outcome

I find this an interesting topic with several unknowns

🧵 Image
"Gut inflammation is strongly associated with #Spondyloarthritis (SpA), as exemplified by the high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of subclinical gut inflammation in patients with #SpA."

nature.com/articles/s4158… Image
"Gut #Microbiome composition differs across regions and ethnicities, changes over time, and can be influenced by multiple factors, including, among others, diet, lifestyle, hormonal cycles, disease, comorbidity..."

'Gut microbiome in #Rheumatic diseases'
ard.bmj.com/content/80/11/… Image
Read 11 tweets
This is the most straightforward explanation for chronic symptoms in at least a subset of #LongCovid patients. Partly b/c if the #virus is still present its activity can directly contribute to other phenomena also being documented in LongCovid
2/ Persistence of #SARS-CoV-2 in tissue could lead to shedding of spike protein into blood, which can catalyze the ongoing formation of microclots and hyperactivated platelets
3/ Persistence of SARS-CoV-2 can lead to ongoing downregulation of interferon and/or T cell signaling by the virus, creating an optimal atmosphere for activation of EBV or other #pathogens normally controlled by such immunity
Read 10 tweets
Interested in #phages, #metagenomics and #microbiome? New method out to bin #phages from shotgun metagenomics data by @jojohansen from our group. (1/12)

nature.com/articles/s4146…
Discover and analyse #phages in any #Metagenomics shotgun dataset by:

1. Bin and identify high quality phage bins
2. Automatically defines viral populations across samples
3. Analysis of viral-host interactions within samples
Using two paired #metagenomics and #metaviromics datasets:

17-36% of HQ viruses in metavirome was found from metagenomics samples using PHAMB

46-89% of HQ viruses found by PHAMB in metagenome data was not found in the metavirome
Read 13 tweets
📢New paper out in @mSystemsJ, coauthored w/ the amazing @MeghanAzad!
Inspired by community #ecology theory and computational #microbiome methods, we propose a novel strategy for studying #humanmilk.

journals.asm.org/doi/10.1128/ms…
We focused on 3 major barriers to understanding #breastmilk
1⃣Milk contains thousands of components, yet most studies analyze just one or a few
2⃣Milk changes over time, yet longitudinal studies are rare
3⃣We lack computational tools & methods to study milk as a complex SYSTEM
From a #DataScience perspective, to study complex biological processes such as #humanmilk and lactation, it is essential to take an integrative and ‘multi-layer’ approach.
Read 11 tweets
📣New paper out in @mSystemsJ, coauthored w/ the fabulous @LiatShenhav!
In this review, we apply our (very!) different skillsets to propose a new strategy for studying #humanmilk as a biological system, using methods developed for #microbiome research.
🧵
journals.asm.org/doi/10.1128/ms… Image
👩🏻‍💻Liat is a computational scientist who develops bioinformatics methods to analyze microbiome data.
👩🏻‍🔬I am a human milk scientist who wants to study ALL THE THINGS in milk and figure out how they all work together.
Inspired by this @AJCNutrition review from @ParulChristian, @DrEmilyRSmith & others from @NIH & @gatesfoundation, Liat & I teamed up to brainstorm... 🧠
academic.oup.com/ajcn/article/1…
Read 12 tweets
🧵12 scientific Twitter accounts you should go follow for the latest updates on #GutMicrobiome-host interaction research: 🦠👩‍🔬🧪⬇️

#aging #immune #nutrition #probiotics #brain #SciComm
1/12. @bykriscampbell - Kristina Campbell, MSc, is a #SciComm extraordinaire. Her tweets give excellent summaries of cutting edge #GutMicrobiome-host publications primarily #FMT #probiotics and #Disease
2/12. @john_damianosMD - Dr. John Damianos tweets about all things #Microbes and #Medicine. We're talking #Probiotics, #IBD, and more, from the prospective of a clinician.
Read 18 tweets

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