Discover and read the best of Twitter Threads about #microbiome

Most recents (24)

A 🧵on our new work on preclinical #FaecalMicrobiomeTransplantation studies!

A while back, I began to plan my own #FMT study.

Turns out, the literature is wildly varied but mainly it is pretty difficult to find a protocol that has all the nitty gritty detail you need.

1/
We systematically reviewed all #FMT studies (in mice) in the past decade, extracting all the methodological details they used/reported.

3/
Read 16 tweets
In our recent review on #LongCovid/PASC we bring up the possibility that dysbiosis or imbalance of host #microbiome communities (in ecosytems such as the gut, lungs, or oral cavity) might contribute to at least some LongCovid symptoms: frontiersin.org/articles/10.33…
2/ More specifically immune dysregulation driven by #SARS-CoV-2 might allow pathobionts (bacteria capable of both commensal + virulent acitivty) in the gut, mouth, or other body sites to collectively shift towards a state of imbalance + pro-inflammatory gene/metabolite expression
3/ Conversely, b/c composition + activity of the microbiome can influence host susceptibility and ongoing control of #viral pathogens, exisiting microbiome dysbiosis in a range of body sites may serve as a form of predisposition to LongCovid
Read 11 tweets
Sometimes I hear people dismiss the possible role of a persistent #pathogen (such as a herpesvirus) in the development of a chronic #disease b/c the same pathogen can be found in healthy people
2/ I see it differently 👉 While the presence/absence of a persistent pathogen in a patient with chronic symptoms matters, the real question is: what is the pathogen doing? Is its ACTIVITY different in patients vs. healthy people?
3/ More specifically, in the #patient with chronic symptoms is the pathogen expressing different #proteins/metabolites? And are these proteins/metabolites increasingly interfering with human gene expression, metabolism, and the immune response?
Read 5 tweets
It all depends on a person's geneotype, phenotype, their immune system, fitness and the microbes living in their bodies, pathogen and how they interact. There is a whole world down there we are just discovering.
This is the Boom of Microbiology.
#Microbiome #MicrobeBoom #Biology
This is story about it all. The role of Jane Kangaroo is played by Fauci and Big Pharma. The role of Horton is played alternately by researchers around the world who understand the power and danger of pathogens, spike protein, mRNA gene therapy.
Read 6 tweets
Who is the Dog?

What Have You Done for Bacteria Lately?

"There is a growing recognition of the role for commensal-host PPIs in health"

Me: Then they aren't commensals THEY ARE MUTUALS,
and what have you done for bacteria lately anyway?

biorxiv.org/content/10.110…
Microbiome-derived proteins are linked to disease-associated human pathways by metagenomic and PROTEIN-PROTEIN INTERACTION analyses.
AKA
Mapping microbiome proteins to known PPIs identifies potential MECHANISTIC LINKS to disease>
AKA
Protein-protein interactions (PPIs) have revealed the mechanisms by which pathogens interact with host tissue through in-depth structural studies
of individual proteins.
These interactions are not limited to pathogens as many canonical protein-mediated microbe-associated>
Read 17 tweets
While we're beginning to understand more and more about the #microbiome, research on the #mycobiome (fungi 🍄) is in its infancy. Here is my summary of 🔑 points from @aeprobio's seminar on the latest research on fungi and the gut!

#GITwitter

Bacteria in the #gut outnumber fungi as a class, but at the individual species level can occur in the same numbers.
Most #gut fungi belong to Ascomycota or Basidiomycota
Read 43 tweets
Thank you so much to @DrPraegers for having me to discuss the effects of plant-based diets on the #gut #microbiome! Here are my slides for all to see! 😃

🍅🥑🧅🍑🥦🍒🫑🍊🌶️🍎🍆🍊🫒🍓🥒🍉🥗🥝🦠

#medicine #medtwitter #diet #nutrition #GITwitter #GI #guthealth #health
Just as we do things for heart health and brain health, our #microbiome is an organ of its own (the size of a 🥭), so we need to take care of it!
Read 30 tweets
We are the host playground for viruses and we are still learning about what they do, and how they interact with other viruses and bacteria in our cells.
Read 9 tweets
@MBVanElzakker and I are excited that our new paper on biological factors that may contribute to the development of LongCovid/PASC was published today: frontiersin.org/articles/10.33…
2/ The paper details mechanisms by which RNA #viruses beyond just #SARS-CoV-2 have be connected to long-term health consequences.
3/ It also reviews literature on acute #COVID-19 and other virus-initiated chronic syndromes such as post-#Ebola syndrome or #ME/CFS to discuss different scenarios for #LongCovid/#PASC symptom development.
Read 10 tweets
In a meeting I watched today, microglia priming was mentioned in #LongCovid and #ME/CFS. It’s important to clarify what “microglia priming” means. Microglial priming does not mean that after a trigger has “cleared” microglia remain perpetually activated
2/ Instead, microglia priming goes like this 👉 When microglia or other glial cells detect #infection, injury, or inflammatory mediators, they enter a state of activation in which they change morphology and release their own neuroexcitatory inflammatory mediators
3/ Then, after activating, they retain a “primed” functional state which causes an even more robust response to *subsequent* infectious/immune/#inflammatory challenges. And as cells, microglia live long lives (they are not replaced as often as many other cell types)
Read 13 tweets
If you’re considering studying blockage of GPCRs in #LongCovid or related conditions, please start w/ the understanding that humans are not sterile...and that common human organisms/pathogens express proteins/metabolites that block/dysregulate GPCR signaling
2/ Herpesvirus re-activation is common in #COVID-19, and may impact some LongCovid cases. The herpesviruses alone (EBV, CMV etc) create a wide range of proteins that block GPCR signaling: ncbi.nlm.nih.gov/pmc/articles/P… Indeed, viral hijacking of GPCRs is a big topic in cancer research
3/ Beyond that, many commensal #bacteria derived from the human #microbiome appear capable of expressing metabolites that are GPCR mimics, that directly impact GPCR signaling. That means even changing microbiome dynamics could impact GPCR-related issues: ncbi.nlm.nih.gov/pmc/articles/P…
Read 4 tweets
It's #DBIOtweetorial time, with your host @gibbological from @isbsci. Today, you'll get some facts about the ~10^13 microbes that call your gut home. By the end, I hope that you'll see yourself as much more than a mere human. You are an ecosystem! #EngageDBIO #microbiome 💩🦠🧑‍🔬
In the womb, we are sterile (obgyn.onlinelibrary.wiley.com/doi/abs/10.111…). At birth, our mothers (and surrounding environment) act as our 'sour-dough starter culture,' inoculating us with hundreds-to-thousands of species. The exact composition of this 'microbiome' is as unique to us as our genome.
Topologically speaking, humans are doughnuts. The entire outside of this doughnut is *covered* in microbes (mostly bacteria). Most of our microbes live in the colon. There are about 3*10^13 human cells and 4*10^13 bacterial cells in the body (doi.org/10.1371/journa…).
Read 12 tweets
Here are the new @BritSocGastro guidelines for #IBS in @Gut_BMJ! I'll summarize in 🧵 ⬇️⬇️⬇️!

😖💩🦠🧠🥦🍞💊

#GITwitter #GI #gut #braingut #motility #DGBI #FGID #microbiome #probiotics #MedTwitter #MedEd

gut.bmj.com/content/early/…
🧑‍⚕️-😷
Doctor-patient communication
🧑‍⚕️A strong 🧑‍⚕️-😷 relationship is fundamental to the management of #IBS
😷Patients want their 🧑‍⚕️ to ⬆️empathy, support and information about the nature of IBS, diagnosis, and treatment options
DIAGNOSIS
🩸New pt: CBC, CRP or ESR, celiac serology and, if <45 w diarrhea, fecal calprotectin
➕Make POSITIVE diagnosis based on @RomeFoundation criteria
➡️Refer to #GI when: diagnostic doubt, pt w symptoms that are severe or refractory to 1stline tx,or when pt wants specialist
Read 16 tweets
Thrilled to share a photo of mine made the cover of @CellCellPress! It’s a testament to the vital mission and fascinating research of the @globalmicrobiom... So, what does this image have to do with how your gut #microbiome evolves? Keep reading... #ConservingCultures
The #microbiome is a hot topic in science, but the field has a major problem: we’re not seeing the full picture! Most studies only include participants from urban centers of industrialized nations – despite the fact that non-industrial lifestyles often host greater #biodiversity!
Without addressing this sampling bias in datasets and strain collections scientists can’t fully understand some of our most important and intimate connections with the microbial world. That’s where the @globalmicrobiom (GMbC) comes in... 
microbiomeconservancy.org
Read 18 tweets
Foods in our #diet can alter the pro-inflammatory vs anti-inflammatory milieu of the intestinal #microbiome.

See 🧵 below for the findings!

🥬🍑🍅🍠🥚🍎🧀🍆🫒🫓🍇🥦🥑🥥🥯🌶️🧄🥖

#GITwitter #GI #gut #nutrition

gut.bmj.com/content/early/…
🥖 🥜 🐠 🌰
Breads, legumes, fish and nuts⬇️several pro-inflammatory pathways:
🫓⬇️pathogenic growth factors & endotoxins
🫓⬇️ pathogenic E. coli, Bacteroides fragilis, parabacerioides
🫓⬆️ammonia detoxification pathway
🌰🐟 🍑🥦
Nuts, oily fish, fruit, vegetables & cereals ⬆️short-chain fatty acid producers
🫑⬆️Faecalibacterium prausnitzii, roseburia hominis, and more

Bacteria ferment fiber and pectins to acetate and butyrate.

SCFAs have anti-inflammatory effects on the mucosa!
Read 20 tweets
Excited to share our article presenting the @globalmicrobiom initiative and releasing our first batch of data and results! This work highlights how microbiomes acquire new functionality based on host lifestyle. @CellCellPress.
.
sciencedirect.com/science/articl…
We've known that transitioning from non-industrialized to industrialized lifestyles is associated with changes in gut #microbiome composition and decreased diversity. Whether gut bacterial genomes may also adapt to the industrialization of their host remains largely unexplored.
With @globalmicrobiom scientists, we generated thousands of bacterial genomes from 15 populations spanning a range of industrialization - in the USA, Canada, Finland, Tanzania, Nigeria, Ghana & Cameroon to understand how host lifestyle impact the evolution of our gut microbiomes.
Read 13 tweets
Last year, our sister biotech company @LUCABiologics announced VIRGO, the first comprehensive reference in the gene catalog of the human vaginal #microbiome spearheaded by Chief Scientist Dr. Jacques Ravel. A thread 🧵
This database of nearly 1 million non-redundant genes reveals significant genomic and functional diversity within the vaginal #ecosystem, challenging the widely-held notion that an optimal vaginal microbiome is dominated by one strain. 🧵
This new view of intraspecies diversity has deep implications on the development of gene-centric, microbial therapies to target #diseases like bacterial vaginosis, urinary tract infection, and STI, which impact millions of women globally.🧵
Read 6 tweets
A little late but better late than never! ⌚️ Here's a recap of @AmCollegeGastro Virtual Grand Rounds by @ScottGabbardMD on...... FUNCTIONAL DYSPEPSIA!
🤢🤢🤢

This is a VERY common entity that is underdiagnosed! #MedTwitter take notice!

#GITwitter #GI #gut
DYSPEPSIA = epigastric #pain. (can be associated with any other upper #GI symptom such as epigastric fullness, nausea, vomiting, or heartburn).

Dyspepsia is COMMON, and most cases are FUNCTIONAL (i.e., caused by brain-gut axis dysfunction)!
Like all disorders of gut-brain interactions FD pathophysiology is❌completely understood, but is thought to be complex+multifactorial. Components include
🤢disrupted duodenal barrier
🤢altered duodenal #microbiome
🤢dysmotility
🤢visceral hypersensitivity
🤢psychosocial stress
Read 22 tweets
1/ A: Celebrate the mild #flu season & take what we have learned this year to inform future behavior. Harmful germs are not going away. 🦠 Illness from bacteria & viruses that make us sick do not “strengthen” the #immune system & contribute to significant complications & death. Image
2/ The lack of infectious illnesses will not #weaken your #immunesystem. Public health measures to combat #COVID19 including social distancing, masks, & extra hand washing greatly reduced the incidence of some bad microbes that cause common infectious illnesses such as the flu.
3/ More than 15,000 US deaths attributed to the #flu were averted this year. Other common viruses, like rhinoviruses, did not decrease as consistently. #Bacteria & #viruses that cause illness will continue to exist. go.nature.com/2OxkiUv
Read 9 tweets
THREAD
Are the social distancing measures damaging our immune systems? Less contact = reduced infection rates.
For example, the number of reported whooping cough cases during the reporting period 2020/2021 is less than 5% of that of the previous year
1/
@PHE produce weekly updates on statutory notifiable diseases and usefully provide comparisons to previous years. As might be expected, there has been significant decline in all. A few more graphs below to illustrate this 👇
2/
As well as whooping cough, there are significantly fewer reported cases of #meningococcal septicemia, acute #meningitis, #measles and #mumps
3/
Read 13 tweets
Let's talk about something common, hard to treat, and often misunderstood: CHRONIC BLOATING AND DISTENSION!

A 🧵 summarizing from the excellent @AGA_CGH article cghjournal.org/article/S1542-…

#GI #GITwitter #motility #IBS #DGBI #FGID #microbiome #health #MedEd
🟢Bloating: subjective sensation of gassiness, trapped💨, or a feeling of pressure or being distended w/o obvious visible distension.

🟢Distension: objective physical manifestation of an⬆️in abdominal girth. Patients commonly say they look like 🎈 or 🤰
Bloating and distension are COMMON

🔴16-31% in the general population

🔴Women > men

🔴66-99% in #IBS

🔴IBS-C > IBS-D

🟢Bloating and distension are distressing to patients and ⬇️quality of life
Read 13 tweets
My name is Fancy and I'm taking part in the #GlobalScienceShow
Today I'm going to show you some of my #SciArt works combining industrial design to communicate science!

Check @GlobalSciShow and follow for the whole show ✨🔬✏️👋🏽

#scicomm #comunicacienciachile #industrialdesign
I’ve always been passionate about #science but I also loved #art and wanted to create products, so I studied #industrialdesign, art and #architecure and now I use different techniques & disciplines I’ve learned to express ideas and to explore new ways to communicate science
#IndustrialDesign is a PROCESS OF DESIGN applied to products where design precedes manufacture. Is the #creative act of determining & defining a product's form and features and as an applied art focuses on a combination of aesthetics, user, form, function & physical ergonomics
Read 11 tweets
Latest paper is up! We fed mice high protein diets for 24 weeks and measured the #microbiome 🦠, #kidney function and #gut leakiness. Here's what we found: onlinelibrary.wiley.com/doi/abs/10.100… @sihmin_tan @MelindaCoughlan @MonashDiabetes
1) high protein diets alter the microbiome...but what's interesting is when we looked at the predicted metagenomes (using picrust2) we saw⬇️BCAA synthesis and⬆️urea cycle pathway.
2) the high protein diet caused inflammation and intestinal permeability:
⬆️ plasma endotoxin
⬆️ plasma MCP1
⬆️ TNFα expression in jejunum and ileum
⬇️ occludin expression in jejunum
Read 5 tweets

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