Discover and read the best of Twitter Threads about #pancreatic

Most recents (7)

Really pleased to share the results of the #LongCovid study I was part of with the Perspectum team out of Oxford University. Using a specialist new technology this focused on assessing multiple organ damage in 'first wave' patients, infected with #COVID in early 2020 or even 2019
We were given in-depth haemotological tests, respiratory assessments and most importantly whole organ scans using the new 'MRI' type enhanced scanning equipment. My first test showed #myocarditis, three liver #lesions, reduced #kidney function and multiple organ inflammation
Also in the first year I experienced #TIA, #atrialfibrillation, #septic bursitis, pre-diabetic symptoms, complete loss of taste & smell; hair loss; #polyarthritis joints, abdominal and bone pain plus multiple #infections and skin eruptions Some neuralgia, headaches and brain fog
Read 5 tweets
1/9 #TumorBoardTuesday Friday Case Wrap Up

🚨Special Friday Edition of #TBT🚨
This week, mgmt of #Pancreatic neuroendo tumors (pNET), led by @nanudasmd. We discussed SOC, role of IO, & brand🆕 💊. Buckle up! We captured the discussion in this moment:…
2/9 #TumorBoardTuesday Friday Case🎀
We discussed #pNET:
✅Well diff= sens to cape/tem; high% of MGMT methylation -but not predictive of response
✅Tx dictated by disease extent
✅NOT all NETs are ➕ on dotatate! If they are, ☢️PRRT option- but may use late line
2.5/9 #TumorBoardTuesday Friday Case🎀

Take 🏠 messages continued:

✅Mixed track record of IO, despite TMB increase s/p TMZ. Higher prolif rate = better IO response
✅New: belzutifan (HIF-2a inhibitor) w activity in pNET!
✅Each pt is different- 💊 customized to pt situation
Read 12 tweets
Cool paper detailing what body sites, cell types, symptoms #COVID-19 has been connected to thus far 👉 But one thing: everyone knows that most persistent #viral (and #bacterial) pathogens are capable of #infecting/driving an equally extensive # of #symptoms, right?
2/ For example, in this interview, Dharam Ablashi (who co-discovered the #virus HHV6) explains how HHV6 has been shown capable of contributing to #cancers, type 1 #diabetes, Hashimoto’s, #MS, HPA-axis dysregulation, ME/CFS, Alzheimer’s,…
3/ ..and that the HHV6 can survive in
#microglia, astrocytes, macrophage, neurons/nerves, #pancreatic islet cells, the lung, gut epithelial cells, the #liver etc etc etc!
Read 6 tweets
Hey! Based on the article below, is anyone looking at HIF-1 alpha expression in #pancreatic beta cells in #COVID-19 cases associated w/ #diabetes? B/c this team found COVID-19 cld infect pancreatic beta cells in a human organoid model:…
2/ HIF-1 alpha expression in pancreatic beta cells is required for type 1 #diabetes prevention. And, this team found that if HIF-1 is knocked down in such cells they have a poorer response to RNA #virus infection (such as coxsackie virus infection): Image
3/ Also, separate topic, but this team found that certain #viruses express peptides w/ homology to human #insulin/insulin-like growth factors. In the lab, the viral hormones cld bind mouse/human insulin receptors and modify their downstream signaling:… Image
Read 3 tweets
Good news! This new human #tumor microbiome study is excellent. They used hundreds of negative controls for contamination + an extensive combo of methods to identify #bacteria in 7 #cancer types (lung, ovary, pancreas, melanoma, bone, brain):… Image
2/ Bacterial LPS + 16SrRNA were frequently detected in all tumor types, w/ #breast cancer harboring a particularly rich and diverse #microbiome. The image below shows LPS/16SrRNA in breast cancer cells. Bacteria were also found in normal breast samples from healthy subjects Image
3/ In one experiment the team grew live #bacteria from three main phyla (Proteobacteria, Firmicutes, Actinobacteria) from fresh breast #tumor samples collected from women undergoing breast surgery
Read 5 tweets
#Pancreatic #cancer will soon overtake breast cancer in fatalities in Australia. It's difficult to diagnose and 9 out of 10 patients die within five years. Now there's a push to give it more attention and vital research funding. #abc730 @ashmcghee
Helen MacGregor was first diagnosed with #pancreatic cancer in 2018. “I didn’t even know what pancreatic cancer was back then.” #abc730
Helen was part of a clinical trial of a new immunotherapy to treat the #cancer, but it wasn’t successful. “I also found out that the tumours had doubled in size. It was upsetting because I was doing this not just for myself but for everyone fighting this.” #abc730
Read 7 tweets
Article says 97% of new drugs tested for cancers never make it to market 👉 IMO key to better #cancer therapies will require widespread recognition of the tumor #microbiome/virome...+ the fact that pathogens in such communities can drive changes in #tumor gene expression
Good example of the trend 👉 “Our study demonstrates that #pancreatic adenocarcinoma (PDAC) #microbiome composition, which cross-talks to the gut microbiome, influences the host immune response and natural history of the disease.”… ImageImage
Or 👉 “...these data indicate that microbial DNA is present in the #breast and that #bacteria or their components may influence the local immune microenvironment. Our findings suggest a previously unrecognized link between dysbiosis and breast cancer”:… ImageImage
Read 5 tweets

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