OK, looks like Democracy is safe for now, and the push for reform is making headway. There's a long road ahead, but I'll take a brief timeout to report from @NYASciences's #Phenotypic2020 virtual conference.
First keynote was @OlgaTroyanskaya, presenting a range of tools for understanding #NonCoding genomic variants: DeepSEA, ExPecto, Fenrir...
Emphasizes that #ComplexDisease relies on networks and complex changes like #Aging, so we have to stop looking for 1->1 causal maps. Agree!
Andrea Califano from @columbiacancer using combination of #HTS and #SingleCell Plate-Seq to look for cancer master regulators. VIPER identifies proteins whose regulatory effect impacts genes that distinguish cell states. Now running phase 1 trial!
@TraverHart on philosophy of #CRISPR.
Joking aside: finds "missing hits" in knockout screens where paralogues exist, co-essentiality within and across pathways. "Easy to screen, hard to analyze". Calls for more #Polygenic screens to understand disease biology.
#Phenotypic2020
Missed a few, now @betastarfish presenting diligent MOA studies for compounds preventing beta cell death and ones increasing insulin secretion. I didn't realize that 25-50% of diabetes cases are undiagnosed!
"Very few drugs actually target beta cells, the root of the problem"
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