Thread by @HenningWillers

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🚨Delighted to do a quick #tweetorial on our short report in the💚#GreenJournal @RadiotherapyOn1

☢️Heterogeneous immunogenicity of SARS-CoV-2 vaccines in #cancer patients receiving
#radiotherapy💉

➡️thegreenjournal.com/article/S0167-…

#radonc #COVID19 #CovidVaccine #lcsm
#OncoAlert

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Inspired by:

[Our patients]
Doctor, is the #radiotherapy I am getting affecting how well my #CovidVaccine works?

[Us]
🤷

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There is large heterogeneity when looking at immunogenicity of #COVID19 vaccines in #cancer patients & esp #lungcancer patients shown by @vivek_naranbhai & team in @JCO_ASCO

Chemo may suppress antibody levels somewhat.
What about #radiotherapy?

➡️ascopubs.org/doi/pdf/10.120…

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In a smaller but unique cohort of #lungcancer patients receiving #CovidVaccine shortly before, after, or during thoracic #radiotherapy, antibody levels were lower than in non-radiation (RT) patients or health controls (HC) 🤔

sciencedirect.com/science/articl…

@sueyom @VPrasadMDMPH

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However, 55% of patients had potentially immunosuppressive conditions = recent receipt of chemotherapy, chronic kidney disease, CLL, immunosuppressive medication🤔

These had lower Ab levels🥀

🚨The other #radiotherapy patients had Ab levels comparable to healthy controls🚨

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➡️This needs to be validated in larger cohorts & different #radiotherapy patients

Is it possible that large field #radiotherapy could affect #CovidVaccine immunogenicity via lymphopenia or impacting lymph node function⁉️

@CGrassberger @StevenLin_MDPhD @vivek_naranbhai

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4 received additional #CovidVaccine doses with favorable Ab response especially in those who had initially low levels

➡️However what will be the duration of response in immunosuppressed people❓

➡️This data highlights usefulness of measuring Ab titers in #cancer patients🚨

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Last but not least:

Thanks to @JustinGainor @vivek_naranbhai @MGHThoracicOnc @BalazsLab & whole team for making this happen🙏

Thanks to our patients for participating🙏💕

We learned a lot actually + it helped our patients😊

Learn more here: canvax.org/publication-in…

#lcsm