The story of Omicron so far - virulence, severity, and hospitalisations across the globe.
🧵of tweets from reliable sources
1/ Who is more vulnerable to Omicron infection? @EricTopol
@EricTopol 2/ The lower severity of Omicron cases - Reasons? @RajeevJayadevan
@EricTopol @RajeevJayadevan 3/ Omicron less severe illness #COVID19 - data from South Africa
@EricTopol
@EricTopol @RajeevJayadevan 4/ Two factors: Infection-everted and Re-infections, which may explain why Omicron appears less severe. @nataliexdean
5/ Is Omicron intrinsically less severe? @jburnmurdoch
6/ Cases are rising steeply in London. But what about hospitalisations? @jburnmurdoch
@jburnmurdoch 7/ Share of Omicron cases requiring hospital is lower than for Delta. @jburnmurdoch
@jburnmurdoch 8/ Immune evasion vs Disease progression #Omicron @GuptaR_lab
@jburnmurdoch @GuptaR_lab 9/ CPE & cell-cell fusion #Omicron
@matmartinsvet
Cytopathic effect or cytopathogenic effect (abbreviated CPE) refers to structural changes in host cells that are caused by viral invasion.
@jburnmurdoch @GuptaR_lab @matmartinsvet 10/ Omicron case severity in South Africa & UK. @danielgoyal
@jburnmurdoch @GuptaR_lab @matmartinsvet @danielgoyal 11/ Omicron in London @alexselby1770
@jburnmurdoch @GuptaR_lab @matmartinsvet @danielgoyal @alexselby1770 12/ Age controlled data on Omicron severity. @sailorrooscout
@jburnmurdoch @GuptaR_lab @matmartinsvet @danielgoyal @alexselby1770 @sailorrooscout 13/ People with Omicron are 50- 70% less likely to need hospital care. @BBCBreaking
14/ What to expect from the Omicron wave? @trvrb
@trvrb 15/ Daily hospitalizations and deaths #Gauteng #SouthAfrica #Omicron
@ScottGottliebMD
16/ Rapid turnaround #Omicron #COVID19 @EricTopol
17/ Hospitalizations as per three studies #OmicronVariant @ScottGottliebMD
18/ Lung infectivity
Omicron vs Delta
19/ Severity of Omicron compared to Delta. @AnuragAgrawalMD
20/ Infectivity in hamsters @EricTopol
21/ Omicron - Cross Neutralization - Delta
@sigallab
22/ Extensive mutations in #Omicron might have knocked out a lot of nAb binding sites, but a lot of spike protein is still not mutated, which T cells of vaccinated/ previously infected people recognize easily.
Read this thread by @virusmonologues
23/ Functional preservation of T cell responses against #Omicron
@SetteLab @profshanecrotty
24/ Five independent studies have shown that Omicron cannot infect lung cells as efficiently as the previous variants. @EricTopol
26/ Now 6th study shows Omicron affects lungs less - compared to Delta and previous variants of concern. #COVID19 @EricTopol
27/ Ireland cases, positivity are all rising but very few hospitalizations
@EricTopol
28/ South African data @FaheemYounus
29/ Reduced clinical symptoms with Omicron variant #Covid_19 @Marc_Veld
30/ Why is Omicron variant not able to infect lower airway cells?
Why is its infection efficiency limited to upper airway cells?
Why has Omicron's capacity to induce cell-cell fusion & syncytia formation significantly reduced compared to Delta?
Thread:
31/ Syncytia formation is not seen with Omicron, whereas it was a pathogenic characteristic of earlier variants such as D614G and Delta. @juli_bg_bs
32/ Only the immuno-compromised ones are having complications. #Omicron #COVID19 @kit_delgadoMD
33/ There is a drastic difference between the first wave of 2020 and the current Omicron wave in USA.
A thread from the COVID-19 frontlines. @Craig_A_Spencer
34/ Omicron < Substantially milder < Earlier variants @sailorrooscout
35/ The reason behind reduced pathogenicity of Omicron compared to earlier variants
36/ Cases vs mortality in USA #Omicron #COVID19 @sailorrooscout
37/ The UK picture is becoming clearer. Less severity is really a thing. @EricTopol
38/ Less severe disease and fatality rate. #Omicron #COVID19 @EricTopol
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