#COVID =
+ Age-independent
+ Creeping
+ Delayed Noticed
+ Potentially Persistent
+ Evoking Auto-Antibodies
+ Reinfections Usually More Severe
+ Damage Probably Cumulative
+ Insufficient Immune Protection in Convalescent
+ Potential Brain Damage Despite Vaccination
👴👶👩🦰 AGE-INDEPENDENT
#Covid damage has been demonstrated in children & adults. In addition to the dead & sick in the acute phase of #Covid, come the people with later occurring symptoms, which are summarized under the term #LongCovid. #LongCovidKids
reuters.com/article/us-hea…
🦠🕶️🕵️ CREEPING
Vascular & organ damage occurs even in mild/symptomless courses.
"Microthromboses also in children - Biomarkers suggest vascular & Renal Damage Even in Asymptomatic Infections."
scinexx.de/news/medizin/c…
ashpublications.org/bloodadvances/…
🫁🏚️ LUNG-DAMAGE in ASYMPTOMATIC
Lung injury even in asymptomatic children: "Pulmonary imaging COVID-19: a series of 140 Latin American Children"
ncbi.nlm.nih.gov/labs/pmc/artic…
"A study of 104 passengers found that 76 of them had COVID but were asymptomatic. Of that group, CT scans showed that 54 percent had lung abnormalities—patchy gray spots known as ground glass opacities that signal fluid build-up in the lungs."
nationalgeographic.com/science/articl…
⏳⌛️⏳ DELAYED NOTICED
And often remain unnoticed for longer (weeks/months) until symptoms appear #LongCovid #LongCovidKids
welt.de/regionales/ham…
▶️⏸️▶️ POTENTIALLY PERSISTENT 🧠🫀🫁👁️
The virus has been detected <=6 months #postcovid, in DEAD people in heart, brain, eyes, lungs, lymph nodes & adipose tissue, BUT also in the LIVING
in GI & hepatic organs 🚽🧻.
➡️ Unclear what % of population is affected. 🤔
(chronic ?)
👹🥷🫀 EVOKING AUTO-ANTIBODIES
In this study, ALL 177 screened medical employees were found to have autoantibodies 6 months #postcovid.
…nslational-medicine.biomedcentral.com/articles/10.11…
#HerdAutoImmunity ???
🤒😷🤒 REINFECTIONS USUALLY MOE SEVERE
clinicalmicrobiologyandinfection.com/article/S1198-…
🏚️➕🏚️ DAMAGE PROBABLY CUMULATIVE
🛡️👎🏚️ INSUFFICIENT IMMUNE PROTECTION IN CONVALESCENT
🦠👃🧠POTENTIAL BRAIN DAMAGE DESPITE VAX
sciencedirect.com/science/articl… : "A spike vaccine confers acute protection in lung, but not in brain"
#LongCovid which hints towards #NeuroCovid:
medrxiv.org/content/10.110…
reuters.com/business/healt…
nature.com/articles/d4158…
->#intranasal vaccines?
BRAIN DAMAGE
🐵🧠🔥
LEWY BODIES & INFLAMMATION in the BRAIN
SARS-CoV-2 causes brain inflammation & Lewy bodies, a hallmark for Parkinson, after an asymptomatic infection in macaques.
It was found weeks #postcovid in brains of ALL rhesus macaques.
biorxiv.org/content/10.110…
➖🧠👎 IQ-LOSS EVEN in UNHOSPITALIZED
"After mild #Covid courses average nearly a 1/4 standard deviation loss in cognitive performance.
Equivalent to mean loss after stroke or 3-4 points lower on IQ scale." via @epsilon3141
After ONE infection!
thelancet.com/journals/eclin…
🦠🍝🧠 LOSS of GRAY MATTER
"MRI study (preprint): Brain scans before and after COVID-19 infection (96% not hospitalized) show a decrease in gray matter in brain regions important for smell, memory, and emotions."
via @quervain_de
After ONE infection!
medrxiv.org/content/10.110…
🦠🧠🦠 VIRUS RIDDLED BRAIN
Brain riddled with virus, months after "recovering" found in dead:
researchsquare.com/article/rs-113…
🩸🏚️🧠 DISRUPTS the BLOOD-CSF-BARRIER
biorxiv.org/content/10.110…
cell.com/cell-stem-cell…
🩸🔥🏚️ ENDOTHELIUM INFLAMMATION & DAMAGE
-> microclots -> undercirculation -> undersupply of tissue, pic via @hjelle_brian
sciencealert.com/young-adults-w…
🫁👎🩸 PULMONARY VASCULOPATHY
🫁☢️:
🩸🏚️🩸 MICROCLOT FORMATION
"A recent study in my lab found that significant microclot formation occurs in the blood of both acute covid-19 and long covid patients."
via @gernot_ruzicka & @ @Dr2NisreenAlwan
theguardian.com/commentisfree/…
🔬🩸🧱 ELEVATED D-DIMER LEVELS in case of MICROCLOTS
⏳🏚️🩰 KIDNEY DAMAGE & DECLINING FUNCTION
"SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids"
sciencedirect.com/science/articl…
via@limits_stop
🩸🍬 👎 PANCREAS DAMAGE resulting i DIABETES 1&2
New cases of diabetes due to Covid "The risk amounts to about 6.5 additional cases of diabetes per 1k Covid-patients who do not end up in the hospital. For those who do, the probability rises to 37 per 1k"
fortune.com/2021/05/05/dia…
"We are all seeing an increase in type 1 diabetes diagnoses as well as in Type 2 diabetes diagnoses [note in children]. Those of us who have have been tracking this have seen a 30% to 40% increase vs. to (2019)."
mississippifreepress.org/15930/pediatri…
"This year, more infants have developed type 1 Diabetes at Skaraborg than ever before at Skaraborg Hospital."
sverigesradio-se.translate.goog/artikel/fler-s…
"Pediatrician from Kassel Hospital: Increase in type I diabetes and inflammatory bowel diseases"
hna.de/kassel/corona-…
👨💔👩🦰 POTENCY PROBLEMS & INFERTILITY
"an impairment of spermatogenesis has been partially explained by an increased immune response in the testes. In addition, some COVID-19 patients developed an Autoimmune orchitis (self-destructive testicular inflammation)"
thelancet.com/journals/eclin…
scilogs.spektrum.de/fischblog/unfr…
nature.com/articles/s4142…
ncbi.nlm.nih.gov/pmc/articles/P…
And here's another compilation of horror (mostly other studies linked). Highly recommended! 👍😄
😄⌛️🤒 HEALTHY YEARS LOST
i.e for girls under 10 this paper says it's 5.71 years of healthy life lost:
jclinepi.com/article/S0895-…
🩸👛🍅 BLOOD CELL ALTERATIONS
"As researchers at the Max Planck Center for Physics and Medicine in Erlangen have discovered, Covid-19 disease significantly alters the size and rigidity of red and white blood cells - in some cases for months."
mpg.de/17108102/long-…
"Lymphocytes (defense cells that are part of the white blood cells) were again significantly softer in corona patients, which may indicate a strong immune response.
The researchers made similar observations with neutrophil granulocytes, another group of white blood cells of ...
the innate immune defense. These cells remained drastically altered seven months after acute infection. "We suspect that the cytoskeleton of the immune cells, which is largely responsible for cell function, has changed."
@fitterhappierAJ
Here is the paper about the altered blood cells:
cell.com/biophysj/fullt…
🧠🏚️ MYELIN-LOSS
"Impaired neurogenesis i the hippocampus, a decrease in oligodendrocytes & MYELIN LOSS in the subcortical white matter were evident after only one (!) week & persisted until at least 7 weeks after mild SARS-CoV-2 respiratory infection in🐭
biorxiv.org/content/10.110…
At the same time, the mice also had elevated levels of CCL11 - a cytokine/chemokine - 7 weeks after infection (in this case NOT associated with neuroinvasion). Also LongCovid patients both with and without cognitive symtoms equally
had elevated plasma CCL11 levels.
"CCL11, may also limit neurogenesis & contribute to cognitive impairment (Villeda et al., 2011)"
"A meta-analysis of 45 studies involving nearly 10,000 subjects found that more than 70% of people had at least
ein Symptom haben, das länger als zwei Monate nach der Infektion noch anhält, wobei 25 % der Menschen von kognitiven Störungen betroffen sind, selbst diejenigen, die eine leichte SARS-COV-2-Infektion hatten (Nasserie et al., 2021)"
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