Thread by @thelablab

The 'default mode network' (#DMN) is the neurobiological poster child for #psychedelic #drugs (e.g., see #HowToChangeYourMind). A preliminary meta-analysis from the @PsychedelicUNIT suggests this might be overstated, w/ other regions being more impacted, like ye olde cerebellum.

These results are from 'classic' #psychedelics like #LSD and #psilocybin taken by healthy people during resting-state neuroimaging. We used dose as a covariate. A possible caveat is that we mixed blob and functional connectivity analyses which we will now try and model.

The details will soon be in a preprint and we will make the code and larger dataset publicly available. We hope this will help others to address their own questions with further meta-analyses. For example, we asked....

Are changes in networks involved in language and memory partly responsible for the the profound experience of 'oneness' and the loss of self sometimes wrought by psychedelics? See: lab-lab.org/harle-et-al-20…

By the way, to learn more about the cerebellum, once considered the organ of sexuality, see this amazing work of art by @danlametti et al. It deserves to be cited more... direct.mit.edu/jocn/article/3…

Also, you MUST read this immensely erudite review of the relationship b/n the #neurobiology of #language, #innerspeech, and #consciousness as it is the foundation of much of the thinking that went into the above meta-analysis... 💬🧠💕👇sciencedirect.com/science/articl…

Shot out to an earlier neuroimaging meta-analysis of #tryptamine psychedelics (with @mcastelobranco1). Arguably not much of a #DMN story there either...
frontiersin.org/articles/10.33…

@ETagliazucchi you inspired us to recreate a version of your Figure 2 showing the overlap between 5-HT2A receptors (95% threshold) and our language meta-meta-analysis (alpha < .01; forthcoming). 💬🍄🤯frontiersin.org/articles/10.33…